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October 1996

Corneal Endothelial Cell Loss After Excimer Laser Keratectomy, Associated With Tranquilizers

Arch Ophthalmol. 1996;114(10):1282-1283. doi:10.1001/archopht.1996.01100140482026

Severe complications of excimer laser photorefractive keratectomy (PRK) are rare. Nevertheless, a noninflammatory corneal ulcer after PRK has been described in a patient with systemic lupus erythematosus.1 We report a severe loss of corneal endothelial cells and residual stromal haze after PRK in a patient with a long history of tranquilizer use.

Report of a Case.  A 55-year-old man with no history of ocular surgery, trauma, or disease (including dry eye syndrome) underwent PRK on the right eye to correct anisometropia. Before surgery, the uncorrected visual acuity was 4/200 OD and 20/20 OS. The best-corrected visual acuity was 20/20 OU. The manifest refractive error of the right eye was -7.50 sphere. The corneal endothelial cells had a normal hexagonal pattern, and densities were 3884 cells/mm2 in the right eye and 3637 cells/mm2 in the left eye.We used an excimer laser (VISX model Twenty/Twenty, VISX

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