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November 1996

Orbital Tumor in a Child With Posttransplantation Lymphoproliferative Disorder

Author Affiliations

St Louis, Mo

Arch Ophthalmol. 1996;114(11):1422-1423. doi:10.1001/archopht.1996.01100140622023

Posttransplantation lymphoproliferative disorder (PTLD) is a condition characterized by a family of tumors, most commonly of B-cell origin, that occur in organ transplant recipients. Posttransplantation lymphoproliferative disorder represents a major cause of morbidity and mortality in these patients. Ocular involvement in PTLD is rare. Bilateral iris lesions have been reported in 2 children after undergoing liver transplantations.1,2 Intraocular involvement has been described in 2 adults after undergoing liver and heart transplantations.3,4 We treated an orbital tumor in a pediatric liver transplant recipient.

Report of a Case.  At age 14 months a female patient underwent a liver transplantation for biliary atresia. She had been receiving low-dose immunosuppressive treatment with a combination of cyclosporine and prednisone without complications until age 4 years, when she was seen with fever and malaise. Computed tomography of the abdomen disclosed a mass adjacent to the bile duct; biopsy disclosed malignant lymphoma.A mass in

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