We conducted our study to see if informal claims of substantial improvement among those participating in the protocol in Cuba could be supported by measures of visual function. Dr Peláez was well aware of our investigation and corresponded with us about this in April 1995. It would seem that he and his coworkers would welcome an independent assessment of their work. Unfortunately, we could find no benefit based on our measurements of visual acuity, visual field area, and electroretinogram within the time frame of claimed improvement.1Our study sample seemed to be representative of the common forms of retinitis pigmentosa for severity of disease. As stated in the article, the average electroretinographic amplitude was consistent with data previously reported for patients with the common forms of this disease after considering their mean age. One of the 10 patients had Usher syndrome, type II; the prevalence of Usher
Berson EL, Remulla JFC, Rosner B, Sandberg MA, Weigel-DiFranco C. Evaluation of Patients With Retinitis Pigmentosa Receiving Electric Stimulation, Ozonated Blood, and Ocular Surgery in Cuba-Reply. Arch Ophthalmol. 1997;115(1):133–134. doi:10.1001/archopht.1997.01100150135035
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