In this issue of the Archives, investigators1 continue to explore the effect of surgical removal of subfoveal choroidal neovascularization (CNV) in patients with the ocular histoplasmosis syndrome (OHS). The ultimate aim of these efforts1-6 is not to improve vision, but to provide a better outcome than if no surgery was performed, with an acceptable risk-benefit ratio. In the series by Berger et al,1 12 months after submacular surgery, 29% of eyes evaluated had improved by 2 or more Snellen lines of visual acuity while only 13% had worsened by 2 or more lines. These outcomes may be judged to be good for a condition in which subretinal fibrovascular tissue is proliferating beneath the center of the foveal avascular zone and which has been considered untreatable prior to consideration of submacular surgery. However, as discussed by the authors,1 without an adequate reference or
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Bressler NM. Submacular Surgery: New Information, More Questions. Arch Ophthalmol. 1997;115(8):1071–1072. doi:10.1001/archopht.1997.01100160241017
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