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November 1997

Scanning Slit Confocal Microscopy of Fungal Keratitis

Author Affiliations

From the Edward S. Harkness Eye Institute, Columbia University, New York, NY.

Arch Ophthalmol. 1997;115(11):1461-1463. doi:10.1001/archopht.1997.01100160631019

In vivo scanning slit confocal microscopy was performed in a patient with Fusarium solani keratitis. Morphologically distinctive abundant filamentous structures were observed intrastromally. Confocal microscopy of the culture plate growing F solani from the patient's corneal scraping revealed filaments morphologically similar to the filaments observed in vivo. After 1 week of medical therapy, subsequent confocal microscopy showed an increased load of filaments, supporting the decision to perform a penetrating keratoplasty. Confocal microscopy confirmed that all of the fungus was eradicated. This aided in the decision to administer corticosteroids and quickly discontinue antifungal agents.

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