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December 1997

What Is the Evidence Supporting Chemotherapy for Intraocular Retinoblastoma?-Reply

Author Affiliations

Toronto, Ontario

Arch Ophthalmol. 1997;115(12):1604-1605. doi:10.1001/archopht.1997.01100160774026

In reply  Dr Hernandez raises 3 questions about our report on the treatment of intraocular retinoblastoma with chemotherapy, cyclosporine, and focal therapy1; however, in each instance he has failed to notice that the answers to his questions are in the published article. First, the 16 eyes with RE group I to II tumors either contained tumors threatening the macula, where brachytherapy or focal therapy alone would have destroyed central vision, or the other eye had a group V tumor that was treated with chemotherapy, as indicated in our publication (in the Table, in Figure 2 [patient 3], and in the first paragraph of the "Patients and Methods" section).1 We agree that group I to II tumors that do not threaten vision should not be treated with chemotherapy. Dr Hernandez did not notice that brachytherapy was used to treat progressive tumor at the ora serrata after chemotherapy in one

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