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February 2021, Vol 139, No. 2, Pages 142-256

Original Investigation

Risk Factors and Disease Course for Blood-Brain Barrier Disruption–Associated Maculopathy

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):143-149. doi:10.1001/jamaophthalmol.2020.5329

This case series examines the rate of and risk factors for developing blood-brain barrier disruption–associated maculopathy.

Real-Time Imaging of Incision-Related Descemet Membrane Detachment During Cataract Surgery

Abstract Full Text
open access
JAMA Ophthalmol. 2021;139(2):150-155. doi:10.1001/jamaophthalmol.2020.5396

This case series of patients with cataract investigates the intraoperative development of incision-site Descemet membrane detachment associated with a 2.2-mm clear corneal incision during cataract surgery and its associated factors.

Change in Postoperative Opioid Prescribing Patterns for Oculoplastic and Orbital Procedures Associated With State Opioid Legislation

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JAMA Ophthalmol. 2021;139(2):157-162. doi:10.1001/jamaophthalmol.2020.5446

This cross-sectional study identifies changes in opioid prescribing patterns for oculoplastic and orbital procedures associated with the enactment of the Michigan Opioid Laws in 2017 and 2018.

Glaucoma-Related Adverse Events at 10 Years in the Infant Aphakia Treatment Study: A Secondary Analysis of a Randomized Clinical Trial

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):165-173. doi:10.1001/jamaophthalmol.2020.5664

This secondary analysis of a randomized clinical trial identifies and characterizes incident cases of glaucoma and glaucoma-related adverse events among children by the age of 10.5 years and associates these diagnoses with optic nerve head and peripapillary retinal nerve fiber layer assessment.

Estimating Cured Fractions of Uveal Melanoma

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):174-181. doi:10.1001/jamaophthalmol.2020.5720

This study estimates cured fractions (CF) of uveal melanoma using a combination of institutional and epidemiologic data.

Characterization of Retinal Microvascular and Choroidal Structural Changes in Parkinson Disease

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):182-188. doi:10.1001/jamaophthalmol.2020.5730

This cross-sectional study compares the changes in optical coherence tomography parameters and choroidal structural parameters among adults with Parkinson disease and cognitively healthy individuals.

Random Survival Forests Analysis of Intraoperative Complications as Predictors of Descemet Stripping Automated Endothelial Keratoplasty Graft Failure in the Cornea Preservation Time Study

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):191-197. doi:10.1001/jamaophthalmol.2020.5743

This cohort study reanalyzes types of intraoperative complications associated with Descemet stripping automated endothelial keratoplasty (DSAEK) graft failure in the Cornea Preservation Time Study using random survival forests.

Association of Gastric Bypass Surgery With Risk of Developing Diabetic Retinopathy Among Patients With Obesity and Type 2 Diabetes in Sweden: An Observational Study

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JAMA Ophthalmol. 2021;139(2):200-205. doi:10.1001/jamaophthalmol.2020.5892

This cohort study investigates the incidence of diabetic ocular complications in patients with type 2 diabetes after gastric bypass surgery and compared with the incidence in a matched cohort of patients with obesity and diabetes who have not undergone gastric bypass surgery.

Deep Learning Detection of Sea Fan Neovascularization From Ultra-Widefield Color Fundus Photographs of Patients With Sickle Cell Hemoglobinopathy

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):206-213. doi:10.1001/jamaophthalmol.2020.5900

This cross-sectional study evaluates the development of a deep learning method to detect sea fan neovascularization in patients with sickle cell hemoglobinopathy.

Brief Report

Using Historical Data to Support Approval of Drug Products for Ophthalmia Neonatorum: Innovative Approach Toward Evidence-Based Medicine

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JAMA Ophthalmol. 2021;139(2):214-217. doi:10.1001/jamaophthalmol.2020.5558

This comparative effectiveness review uses pooled clinical trial data to evaluate the similarity in the cause of bacterial conjunctivitis and in the treatment response between neonates and older children and adults.

Changes in Treatment-Naive Pigment Epithelial Detachments Associated With the Initial Anti–Vascular Endothelial Growth Factor Injection: A Post Hoc Analysis From the HARBOR Trial

Abstract Full Text
open access
JAMA Ophthalmol. 2021;139(2):219-223. doi:10.1001/jamaophthalmol.2020.5130

This post hoc analysis of a randomized clinical trial investigates changes in treatment-naive pigment epithelial detachments associated with the initial anti–vascular endothelial growth factor injection.

Invited Commentary

In-depth Understanding and Prevention of Cataract Surgery–Related Descemet Membrane Detachment

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):155-156. doi:10.1001/jamaophthalmol.2020.5395

Curtailing Opioid Overprescribing in Ophthalmology

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):162-164. doi:10.1001/jamaophthalmol.2020.5435

Seeing Parkinson Disease in the Retina

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):189-190. doi:10.1001/jamaophthalmol.2020.5719

A Machine Learning Model With Survival Statistics to Identify Predictors of Descemet Stripping Automated Endothelial Keratoplasty Graft Failure

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):198-199. doi:10.1001/jamaophthalmol.2020.5741

Using Adult Drug Efficacy Data to Aid in Interpretation of Underpowered Pediatric Studies

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):217-218. doi:10.1001/jamaophthalmol.2020.5557
Review

Predicting the Future of Genetic Risk Profiling of Glaucoma: A Narrative Review

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):224-231. doi:10.1001/jamaophthalmol.2020.5404

This narrative review discusses genome-wide association studies used to map genes associated with primary open-angle glaucoma as well as the challenges and opportunities in translating such genetic discoveries.

JAMA Ophthalmology Clinical Challenge

A 4-Year-Old Girl With Earache and Double Vision

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JAMA Ophthalmol. 2021;139(2):232-233. doi:10.1001/jamaophthalmol.2020.4057

A 4-year-old child presents with fever, ear pain, and worsening headache and blurry vision with bilateral optic disc swelling. What would you do next?

Bilateral Ptosis and Ophthalmoplegia in a Young Man

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JAMA Ophthalmol. 2021;139(2):234-235. doi:10.1001/jamaophthalmol.2020.4071

An 18-year-old man presents with bilateral gradual-onset ptosis and ophthalmoplegia and has a margin reflex distance 1 of −4 mm OU and a levator function of 0 OU. What would you do next?

Retinopathy With Multiple Cerebral Ring–Enhancing Lesions in a Young Man

Abstract Full Text
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JAMA Ophthalmol. 2021;139(2):236-237. doi:10.1001/jamaophthalmol.2020.4620

A 35-year-old man presents 3 days after a 5-minute generalized tonic-clonic seizure with no other symptoms. He has had a 3-year history of hypertension and a painless decrease of vision over the last 6 years. He has unremarkable neurologic examination results; however, routine blood test results are significant for kidney insufficiency. What would you do next?

A Man With a Cloudy Cornea

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JAMA Ophthalmol. 2021;139(2):238-239. doi:10.1001/jamaophthalmol.2020.4646

A 77-year-old man presents with painless, progressive blurring of vision in his left eye. His ocular history includes previous cataract surgery, followed by yttrium-aluminum-garnet capsulotomy, and Mohs and reconstruction for squamous cell carcinoma as well as a history of multiple skin malignancies. What would you do next?

Research Letter

Intravitreal Anti–Vascular Endothelial Growth Factor Use in France During the Coronavirus Disease 2019 Pandemic

Abstract Full Text
open access has active quiz
JAMA Ophthalmol. 2021;139(2):240-242. doi:10.1001/jamaophthalmol.2020.5594

This cohort study uses data from the French National Health Data System to assess the decline in the use of intravitreal anti–vascular endothelial growth factors before, during, and after pandemic-associated lockdown periods.

Ophthalmic Injuries by Less-Lethal Kinetic Weapons During the US George Floyd Protests in Spring 2020

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):242-244. doi:10.1001/jamaophthalmol.2020.5325

This study investigates the experience of academic ophthalmology residency programs to assess less-lethal weapon eye trauma after the George Floyd protests in Denver, Colorado.

Observation

Teprotumumab for Optic Neuropathy in Thyroid Eye Disease

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):244-247. doi:10.1001/jamaophthalmol.2020.5296

This case report describes a case of compressive optic neuropathy in thyroid eye disease that was sucessfully resolved with teprotumumab.

Coronavirus Disease 2019–Associated Ocular Neuropathy With Panuveitis: A Case Report

Abstract Full Text
free access has active quiz
JAMA Ophthalmol. 2021;139(2):247-249. doi:10.1001/jamaophthalmol.2020.5695

This case report describes a patient with coronavirus disease 2019 who experienced severe ocular neuropathy with panuveitis, resulting in permanent loss of visual acuity.

Ophthalmic Images

Giant Papillary and Peripapillary Staphyloma

Abstract Full Text
online only
JAMA Ophthalmol. 2021;139(2):e204075. doi:10.1001/jamaophthalmol.2020.4075

This case report describes loss of visual acuity in a single eye in a 4-year-old girl because of an oval, mildly tilted optic disc with deep outpouching of the globe.

Peripapillary Haloes Associated With Optic Disc Drusen

Abstract Full Text
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JAMA Ophthalmol. 2021;139(2):e204083. doi:10.1001/jamaophthalmol.2020.4083

This case report describes a patient with peripapillary hyperreflective ovoid masslike structures that could be distinguished from true papilledema.

Rapid Growth of Anterior Chamber Metastasis From Presumed Non–Small Cell Lung Cancer During Targeted Therapy, Responding to a Single Intracameral Injection of Anti–Vascular Endothelial-Derived Growth Factor

Abstract Full Text
online only
JAMA Ophthalmol. 2021;139(2):e204096. doi:10.1001/jamaophthalmol.2020.4096

This case report describes an anterior chamber mass that responded to 1.25 mg of intracameral bevacizumab, in the context of non–small cell lung cancer and new brain metastases.

Pulsating Cilioretinal Artery From Ocular Hypertension

Abstract Full Text
online only has multimedia
JAMA Ophthalmol. 2021;139(2):e204108. doi:10.1001/jamaophthalmol.2020.4108

This case report describes a man with a central scotoma with a pulsating cilioretinal artery, ocular hypertension, and presumed concurrent retinal venous occlusion.

Comment & Response

Video-Conference Interviewing for the Ophthalmology Residency Match

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):249. doi:10.1001/jamaophthalmol.2020.5759

Video-Conference Interviewing for the Ophthalmology Residency Match—Reply

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):249-250. doi:10.1001/jamaophthalmol.2020.5765

Response to a Study Assessing Firework-Associated Ocular Injury in the US

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JAMA Ophthalmol. 2021;139(2):250-251. doi:10.1001/jamaophthalmol.2020.5762

Response to a Study Assessing Firework-Associated Ocular Injury in the US—Reply

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):251. doi:10.1001/jamaophthalmol.2020.5771

Macular Abnormalities Associated With 5α-Reductase Inhibitor

Abstract Full Text
JAMA Ophthalmol. 2021;139(2):251-252. doi:10.1001/jamaophthalmol.2020.5768

Macular Abnormalities Associated With 5α-Reductase Inhibitor—Reply

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JAMA Ophthalmol. 2021;139(2):252-253. doi:10.1001/jamaophthalmol.2020.5774

Conjunctival Findings in Patients With Coronavirus Disease 2019

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JAMA Ophthalmol. 2021;139(2):253. doi:10.1001/jamaophthalmol.2020.5810

Conjunctival Findings in Patients With Coronavirus Disease 2019

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JAMA Ophthalmol. 2021;139(2):253-254. doi:10.1001/jamaophthalmol.2020.5813

Conjunctival Findings in Patients With Coronavirus Disease 2019

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JAMA Ophthalmol. 2021;139(2):254. doi:10.1001/jamaophthalmol.2020.5816

Conjunctival Findings in Patients With Coronavirus Disease 2019

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JAMA Ophthalmol. 2021;139(2):254-255. doi:10.1001/jamaophthalmol.2020.5819

Conjunctival Findings in Patients With Coronavirus Disease 2019—Reply

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JAMA Ophthalmol. 2021;139(2):255-256. doi:10.1001/jamaophthalmol.2020.5822
Correction

Error in Figure Legend

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JAMA Ophthalmol. 2021;139(2):256. doi:10.1001/jamaophthalmol.2020.6407

Error in Byline

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JAMA Ophthalmol. 2021;139(2):256. doi:10.1001/jamaophthalmol.2020.6882

Error in Unit of Measure for Total Choroidal Area and Luminal Area

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JAMA Ophthalmol. 2021;139(2):256. doi:10.1001/jamaophthalmol.2020.6937

Error in Data Presentation in Text

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JAMA Ophthalmol. 2021;139(2):256. doi:10.1001/jamaophthalmol.2021.0050
JAMA Ophthalmology Masthead

JAMA Ophthalmology

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JAMA Ophthalmol. 2021;139(2):142. doi:10.1001/jamaophthalmol.2020.3743
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