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Arevalo JF, Arias JD, Serrano MA. Oral Propranolol for Exudative Retinal Detachment in Diffuse Choroidal Hemangioma. Arch Ophthalmol. 2011;129(10):1373–1375. doi:10.1001/archophthalmol.2011.294
Author Affiliations: Retina and Vitreous Service, Clínica Oftalmológica Centro Caracas, Caracas, Venezuela. Dr Arevalo is now with the Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, and the Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
The main abnormality of the uveal tract in patients with Sturge-Weber syndrome is diffuse choroidal hemangioma (DCH). Diffuse choroidal hemangioma can lead to a total retinal detachment and secondary neovascular glaucoma. Radiotherapy and photodynamic therapy are currently the preferred methods of treatment. Low-dose lens-sparing radiotherapy or proton beam irradiation can induce tumor regression and resolution of subretinal fluid.1 Short-term treatment success using photodynamic therapy has also been reported.2
The use of oral propranolol hydrochloride has been described for infantile orbital3 and periorbital hemangioma. Recently, Léauté-Labrèze et al3 observed that systemic propranolol could inhibit the growth of infantile hemangioma (IH) lesions in children. The response of IH to propranolol catapulted the use of this treatment to first-line status among physicians managing this disease.3-6
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