Ten-Year Evolution of Retinopathy Lesions in an Older Nondiabetic Population | Ophthalmology | JAMA Ophthalmology | JAMA Network
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Research Letter
June 2012

Ten-Year Evolution of Retinopathy Lesions in an Older Nondiabetic Population

Author Affiliations

Author Affiliations: Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney (Drs Wang, Kaushik, Kifley, Cugati, and Mitchell and Ms Rochtchina), and Centre for Eye Research Australia, University of Melbourne, Melbourne (Drs Wang and Wong), Australia; and Singapore Eye Research Institute, National University of Singapore, Singapore (Dr Wong).

Arch Ophthalmol. 2012;130(6):796-797. doi:10.1001/archophthalmol.2011.1574

Retinopathy lesions are common in generally healthy adults without diabetes (6%-13%)1-4 and/or hypertension.1 In the Beaver Dam Eye Study, the 15-year incidence of retinopathy was 14.2% among nondiabetic participants aged 43 to 86 years at baseline5; in the Hoorn Study, the 9-year incidence was 7.3% in persons with normal glucose levels aged 50 to 74 years at baseline.6 We report the 10-year incidence, regression, associated risk factors, and prognosis of retinopathy lesions among Blue Mountains Eye Study participants.


Of 3654 baseline participants aged 49 years and older at the 5-year follow-up, 543 (14.9%) had died, 383 (10.5%) had moved, and 393 (10.8%) refused to participate, leaving 2335 (75.1% of survivors) who attended 5-year visits. At the 10-year follow-up, 1103 (30.2%) had died, 375 (10.3%) had moved, and 224 (6.1%) refused to participate, leaving 1952 (53.4% of the original cohort, 76.6% of survivors) who attended 10-year visits. All examinations were approved by the Human Research Ethics Committees of the Western Sydney Area Health Service and the University of Sydney. Signed informed consent was obtained from participants at each visit.