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Alniemi ST, Griepentrog GJ, Diehl N, Mohney BG. Incidence and Clinical Characteristics of Periocular Infantile Hemangiomas. Arch Ophthalmol. 2012;130(7):889–893. doi:10.1001/archophthalmol.2012.213
Author Affiliations: Mayo Clinic College of Medicine, Rochester, Minnesota (Ms Alniemi); The Medical College of Wisconsin Eye Institute, Milwaukee (Dr Griepentrog); and Division of Biostatistics (Ms Diehl), Department of Ophthalmology (Dr Mohney), Mayo Clinic and Mayo Foundation, Rochester, Minnesota.
Objective To report the incidence, demographics, and clinical findings among a population-based cohort of children with periocular infantile hemangiomas.
Methods The medical records of all patients (<19 years of age) diagnosed as having periocular infantile hemangiomas while residing in Olmsted County, Minnesota, from January 1, 1965, through December 31, 2004, were retrospectively reviewed.
Results Forty-three children were diagnosed as having periocular infantile hemangiomas during the 40-year period, yielding an incidence of 5.4 per 100 000 individuals younger than 19 years (95% CI, 3.8-7.1) or a birth prevalence of 1 in 1586 live births. Thirty children (70%) were female (P < .001). There was a history of maternal infertility in approximately 1 in 5 children and premature birth in 1 in 8 children. Twenty-six children (61%) had other abnormalities, including secondary hemangiomas in 9 (21%). Forty-one patients (95%) had unilateral disease, and 37 hemangiomas (86%) were located on the upper eyelid.
Conclusions In this population-based study, periocular infantile hemangiomas occurred in 1 in 1586 live births and were most prevalent on the unilateral upper eyelid of white female patients. Prevalent associations included maternal infertility and premature birth. Other abnormalities, including secondary hemangiomas in 1 in 5 children, were common in this cohort.
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