Intravitreal Daptomycin in a Case of Bilateral Endogenous Endophthalmitis | Infectious Diseases | JAMA Ophthalmology | JAMA Network
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Research Letter
July 2012

Intravitreal Daptomycin in a Case of Bilateral Endogenous Endophthalmitis

Author Affiliations

Author Affiliations: Department of Ophthalmology and Visual Sciences, The Ohio State University, Columbus (Dr Buzzacco), and Retina Physicians and Surgeons, Dayton (Dr Carroll).

Arch Ophthalmol. 2012;130(7):940-941. doi:10.1001/archophthalmol.2011.2527

Bacterial endophthalmitis is a devastating intraocular infection that, in its most severe form, can result in complete loss of vision in the affected eye. In patients with endogenous bacterial endophthalmitis, 69% have a final visual acuity worse than counting fingers.1 Visual outcomes are directly related to the infecting bacteria, with eyes infected with coagulase-negative Staphylococcus faring much better than those infected with Staphylococcus aureus, Streptococcus, and gram-negative organisms.2 With the emergence of drug-resistant bacteria, increasing the arsenal of safe and effective antibiotics for treatment is of particular importance. We report a case of bilateral endogenous methicillin-resistant S aureus endophthalmitis treated successfully with intravitreal injections of daptomycin.