Intravitreal Daptomycin in a Case of Bilateral Endogenous Endophthalmitis

Bacterial endophthalmitis is a devastating intraocular infection that, in its most severe form, can result in complete loss of vision in the affected eye. In patients with endogenous bacterial endophthalmitis, 69% have a final visual acuity worse than counting fingers.¹ Visual outcomes are directly related to the infecting bacteria, with eyes infected with coagulase-negative Staphylococcus faring much better than those infected with Staphylococcus aureus, Streptococcus, and gram-negative organisms.² With the emergence of drug-resistant bacteria, increasing the arsenal of safe and effective antibiotics for treatment is of particular importance. We report a case of bilateral endogenous methicillin-resistant S aureus endophthalmitis treated successfully with intravitreal injections of daptomycin.