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Research Letter
July 2012

Conjunctival Pediatric Follicular Lymphoma

Author Affiliations

Author Affiliations: Department of Ophthalmology and David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston (Drs Perry and Jakobiec); Ophthalmic Plastic and Orbital Surgery, West Palm Beach, Florida (Dr Rubin); and Department of Ophthalmology, University of Tennessee, Memphis (Dr Rubin).

Arch Ophthalmol. 2012;130(7):941-943. doi:10.1001/archophthalmol.2011.2529

Conjunctival lymphomas constitute 30% of adnexal lymphomas, affect women slightly more than men with median ages of 55 and 63 years in 2 series (<1% occurring in the first 2 decades), and carry a favorable prognosis.1-3 Among childhood systemic lymphomas, only 1% to 2% are pediatric-type follicular lymphomas (PFLs); these lesions are also rarely seen in young adults.4,5 Pediatric-type follicular lymphomas occur predominantly in boys, are frequently localized (36%-79%), have isolated lymphadenopathy and stage I disease, and are most commonly found in the head and neck region.5,6 We describe a dramatic epibulbar, globoid, well-circumscribed conjunctival PFL that was considered clinically to be a pyogenic granuloma in a young man. The distinguishing clinical and immunohistochemical features of adult follicular lymphoma and PFL are described.