ARMS2 A69S Polymorphism and the Risk for Age-Related Maculopathy: The ALIENOR Study | Genetics and Genomics | JAMA Ophthalmology | JAMA Network
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Research Letter
Aug 2012

ARMS2 A69S Polymorphism and the Risk for Age-Related Maculopathy: The ALIENOR Study

Author Affiliations

Author Affiliations: University of Bordeaux (Drs Delcourt, Delyfer, Colin, Dartigues, and Korobelnik and Ms Le Goff), Inserm, ISPED, Centre Inserm U897–Epidemiologie et Biostatistique (Drs Delcourt, Delyfer, Dartigues, and Korobelnik and Ms Le Goff), and Service d’Ophtalmologie, Centre Hospitalier Universitaire de Bordeaux (Drs Delyfer, Rougier, Colin, Malet, and Korobelnik), Bordeaux, and Inserm, U744, Institut Pasteur de Lille, and Université Lille Nord de France, Lille (Drs Lambert and Amouyel), France.

Arch Ophthalmol. 2012;130(8):1077-1078. doi:10.1001/archophthalmol.2012.420

Since the first evidence of an association of age-related maculopathy (ARM) with a locus on chromosome 10q26 (first named LOC387715, then renamed age-related maculopathy susceptibility 2 [ARMS2 ]) was reported,1,2 many case-control studies have confirmed this finding. However, few data are available from population-based studies, which are less subject to selection bias, and few studies have assessed the association of this polymorphism with early ARM.

In this study, we assessed the associations of ARMS2 A69S genotypes with early and late ARM in the framework of a population-based study of French elderly subjects.

The ALIENOR (Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires) Study is a population-based epidemiological study on nutrition- and age-related eye diseases.3 It also aims to assess the association of eye diseases with genetic, vascular, and metabolic factors. Between October 2, 2006, and May 23, 2008, 963 residents of Bordeaux, France, aged 73 years or older were recruited among participants of an ongoing cohort study on vascular risk factors for dementia, the 3C Study.