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Holmström GE, Hellström A, Jakobsson PG, Lundgren P, Tornqvist K, Wallin A. Swedish National Register for Retinopathy of Prematurity (SWEDROP) and the Evaluation of Screening in Sweden. Arch Ophthalmol. 2012;130(11):1418–1424. doi:10.1001/archophthalmol.2012.2357
SECTION EDITOR: LESLIE HYMAN, PhD
Author Affiliations: Department of Neuroscience/Ophthalmology, University Hospital, Uppsala (Dr Holmström); Section of Pediatric Ophthalmology, The Queen Silvia Children's Hospital, Sahlgrenska Academy, University of Gothenburg, Gothenburg (Dr Hellström); Department of Ophthalmology, Linkoping University, Linkoping (Dr Jakobsson); Division of Ophthalmology, Department of Clinical Sciences, Umeå University, Umeå (Dr Lundgren); Department of Ophthalmology, Lund University Hospital, Lund (Dr Tornqvist); and St Erik's Eye Hospital, Stockholm (Dr Wallin), Sweden.
Objectives To evaluate screening for retinopathy of prematurity (ROP) in Sweden and to investigate possible modifications of the present screening guidelines.
Methods Infants in Sweden with a gestational age (GA) of 31 weeks + 6 days or less are screened for ROP. Data from the Swedish national register for ROP (SWEDROP) during 2008 and 2009 were extracted and compared with a national perinatal quality register.
Results In SWEDROP, there were 1791 infants born before a GA of 32 weeks from January 1, 2008, through December 31, 2009. Another 70 infants were registered in the perinatal quality register but not in SWEDROP (dropout rate, 3.8% [70 of 1861 infants]). Seven infants died before termination of screening. In the final study cohort (1784 infants), 15.6% had mild ROP and 8.5% had severe ROP. Treatment was performed in 4.4% of the infants, none of whom had a GA at birth of more than 28 weeks. Nine infants with a GA of more than 28 weeks at birth developed stage 3 ROP, which regressed spontaneously. The total number of examinations was 9286 (964 in infants with a GA of 31 weeks), and the mean (range) number of examinations of each infant was 5.2 (1-30).
Conclusions The SWEDROP, a quality register for ROP, has a national coverage (ie, participation) of 96%. Data from 2008 to 2009 show that it seems possible to reduce the upper limit for screening in Sweden by 1 week, including only infants with a GA of 30 weeks + 6 days or less. However, such a change should be combined with a strong recommendation to neonatologists to refer also severely ill and more “mature” infants.
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