Retinal Reactive Astrocytic Tumor: Gene Expression Profiling | Genetics and Genomics | JAMA Ophthalmology | JAMA Network
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1.
Shields  JA, Decker  WL, Sanborn  GE, Augsburger  JJ, Goldberg  RE.  Presumed acquired retinal hemangiomas.  Ophthalmology. 1983;90(11):1292-1300.PubMedGoogle ScholarCrossref
2.
Rennie  IG.  Retinal vasoproliferative tumours.  Eye (Lond). 2010;24(3):468-471.PubMedGoogle ScholarCrossref
3.
Shields  CL, Shields  JA, Barrett  J, De Potter  P.  Vasoproliferative tumors of the ocular fundus: classification and clinical manifestations in 103 patients.  Arch Ophthalmol. 1995;113(5):615-623.PubMedGoogle ScholarCrossref
4.
Poole Perry  LJ, Jakobiec  FA, Zakka  FR,  et al.  Reactive retinal astrocytic tumors (so-called vasoproliferative tumors): histopathologic, immunohistochemical, and genetic studies of four cases.  Am J Ophthalmol. 2013;155(3):593-608, e1.PubMedGoogle ScholarCrossref
5.
Topol  LZ, Modi  WS, Koochekpour  S, Blair  DG.  DRM/GREMLIN (CKTSF1B1) maps to human chromosome 15 and is highly expressed in adult and fetal brain.  Cytogenet Cell Genet. 2000;89(1-2):79-84.PubMedGoogle ScholarCrossref
6.
Bunt-Milam  AH, Saari  JC.  Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina.  J Cell Biol. 1983;97(3):703-712.PubMedGoogle ScholarCrossref
Research Letter
June 2014

Retinal Reactive Astrocytic Tumor: Gene Expression Profiling

Author Affiliations
  • 1King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
  • 2Summa Health Systems, Akron, Ohio
  • 3Department of Ophthalmology, University of Virginia, Charlottesville
  • 4Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
JAMA Ophthalmol. 2014;132(6):773-775. doi:10.1001/jamaophthalmol.2014.299

Retinal vasoproliferative tumor is a benign tumor with glial cell and vascular components.1,2 The clinical picture was well characterized by Shields and colleagues.1,3 Histopathologically, the low-grade tumor is composed of glial fibrillary acidic protein–positive spindle cells and vascular channels.4 A recent study demonstrated that the main component of the lesion was reactive astrocytes and suggested renaming the lesion retinal reactive astrocytic tumor.4 The authors questioned whether Müller cells, the major retinal glia, were involved in the reactive lesions. In this study, we examined the pathologic features and gene expression profile of an excised vasoproliferative tumor and confirmed the expression of 2 important overexpressed and underexpressed genes.

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