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Original Investigation
October 2014

The Relationship Between Hepatic Lipase Gene Variant and Advanced Age-Related Macular Degeneration: A Meta-analysis

Author Affiliations
  • 1Department of Ophthalmology, Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China
  • 2Department of Oncology, Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, Zhejiang, China
JAMA Ophthalmol. 2014;132(10):1226-1231. doi:10.1001/jamaophthalmol.2014.1752

Importance  To date, no consistency exists across studies that have evaluated the relationship between hepatic lipase gene (LIPC) rs10468017 variant and advanced age-related macular degeneration (AMD).

Objective  To summarize all relevant evidence for a relationship between LIPC variant and advanced AMD.

Data Sources  The PubMed and Embase databases were searched for studies potentially eligible in any language published up to September 15, 2013.

Study Selection  Case-control studies of 2 or more comparison groups that included patients with advanced AMD (choroidal neovascularization or geographic atrophy).

Data Extraction and Synthesis  Allele frequencies and genotype distributions of rs10468017 variant.

Main Outcomes and Measures  Summary odds ratios (ORs) and 95% CIs were estimated under different genetic models using meta-analytic methods. A stratified analysis by advanced AMD subtypes and race/ethnicity was performed, as well as a sensitivity analysis.

Results  Data from 10 case-control studies were included in the meta-analysis. The rs10468017 variant (CT) showed significant summary ORs of 0.81 (95% CI, 0.75-0.88), 0.83 (95% CI, 0.70-0.98), and 0.60 (95% CI, 0.44-0.81) under the allelic (T vs C), heterozygous (TC vs CC), and homozygous (TT vs CC) models, respectively. Carrying at least 1 copy of the T allele decreased the risk of choroidal neovascularization and geographic atrophy by 20% (OR, 0.80; 95% CI, 0.74-0.87) and 29% (OR, 0.71; 95% CI, 0.59-0.86), respectively. The pooled OR for white race/ethnicity under an allelic model was 0.80 (95% CI, 0.74-0.87). The sensitivity analysis indicated the robustness of our findings, and no evidence of publication bias was observed in our meta-analysis.

Conclusions and Relevance  Our meta-analysis indicates that LIPC rs10468017 variant is associated with a reduced risk of advanced AMD. This finding may lead to insights regarding the pathogenesis, prevention, and treatment of AMD.