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Autoantibodies to recoverin are found in the serum of patients with cancer-associated retinopathy syndrome (CAR), in which retinal degeneration occurs in the presence of systemic tumor growth without metastasis to the eye. The presence of antirecoverin antibodies has, so far, been associated with small cell carcinoma of the lung. We describe a patient with an endometrial carcinoma who possesses T cells and antibodies that react with recoverin. The demonstration of autoantibodies in a patient's serum is important to the diagnosis of CAR and cancer and monitoring treatment of diseases. Although several studies have reported the presence of antibodies specific to CAR antigens even before the diagnosis of cancer, to date, no long-term follow-up studies have examined the prevalence of antirecoverin antibodies in those patients' recoverin.
Adamus G, Amundson D, MacKay C, Gouras P. Long-term Persistence of Antirecoverin Antibodies in Endometrial Cancer-Associated Retinopathy. Arch Ophthalmol. 1998;116(2):251–253. doi:https://doi.org/
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