Immunosuppressive Treatment of Choroidal Neovascularization Associated With Endogenous Posterior Uveitis | Allergy and Clinical Immunology | JAMA Ophthalmology | JAMA Network
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Clinical Sciences
November 1998

Immunosuppressive Treatment of Choroidal Neovascularization Associated With Endogenous Posterior Uveitis

Author Affiliations

From the Eye Department, Aberdeen Royal Infirmary (Drs Dees and Arnold) and the Department of Ophthalmology, University of Aberdeen (Drs Forrester and Dick), Aberdeen, Scotland.

Arch Ophthalmol. 1998;116(11):1456-1461. doi:10.1001/archopht.116.11.1456

Objective  To determine whether resolution of choroidal neovascularization (CNV), a recognized sight-threatening complication of endogenous posterior uveitis, and maintenance of vision could be achieved with immunosuppression.

Patients and Methods  Fourteen patients (17 eyes) with CNV associated with endogenous posterior uveitis were enrolled in an open study. Ages ranged from 5 to 51 years. Three eyes had extrafoveal CNV, 6 juxtafoveal, and 8 subfoveal. Three patients were treated with a single course of oral corticosteroids, 2 had additional cyclosporine for up to 2 years, and 9 continued to receive a low-dose regimen of a combination of immunosuppressive drugs.

Results  After a median follow-up of 15 months (range, 7 months to 612 years), 9 of 17 eyes had an improvement in visual acuity; 6 remained within 1 Snellen line of initial visual acuity, and 2 had lost 2 Snellen lines. Angiographically, CNV resolved in 13 eyes, resolved then recurred in 3, and improved but persisted in 4.

Conclusion  These results support a role for immunosuppressive therapy in the treatment of CNV associated with endogenous posterior uveitis.