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Ophthalmic Images
June 14, 2018

Clinicopathological Correlation of Choroidal Invasion in Retinoblastoma

Author Affiliations
  • 1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York
  • 2Department of Ophthalmology, Weill-Cornell Medical School, New York, New York
  • 3Departments of Biomedical Sciences, Ophthalmology and Pathology, Oakland University William Beaumont School of Medicine, Rochester, Michigan
JAMA Ophthalmol. 2018;136(6):e180940. doi:10.1001/jamaophthalmol.2018.0940

Although choroidal invasion in eyes with retinoblastoma is commonly seen through pathological examination, it has rarely been identified with ophthalmoscopy or ultrasonography. Over a 2-month period, a 6-year-old girl who had been treated for bilateral retinoblastoma with systemic chemotherapy, intra-arterial chemotherapy, laser therapy, cryotherapy, and brachytherapy developed a dome-shaped brown-orange fundus lesion that was speckled on its surface with overlying serous retinal detachment (Figure, A). Extension along a ciliary nerve was suspected, and an enucleation was performed. Pathological examination showed that the mass represented massive choroidal invasion without extension into the ciliary body but tracking of tumor cells along a ciliary nerve (Figure, B).

Figure.
A, Ophthalmoscopic image shows a dome-shaped brown-orange fundus lesion and overlying serous retinal detachment. B, Pathological examination shows a massive choroidal invasion without extension into the ciliary body but tracking of tumor cells along a ciliary nerve (arrowheads).

A, Ophthalmoscopic image shows a dome-shaped brown-orange fundus lesion and overlying serous retinal detachment. B, Pathological examination shows a massive choroidal invasion without extension into the ciliary body but tracking of tumor cells along a ciliary nerve (arrowheads).

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Article Information

Corresponding Author: David H. Abramson, MD, Department of Surgery, Memorial Sloan Kettering Cancer Center, 70 E 66th St, New York, NY 10065 (abramsod@mskcc.org).

Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

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