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Case Reports and Small Case Series
January 1999

A Confocal Microscopic Study of Advancing Wavelike Epitheliopathy

Arch Ophthalmol. 1999;117(1):123-124. doi:

Advancing wavelike epitheliopathy was first described by D'Aversa et al1 In their study, 11 eyes of 7 patients were seen with well-demarcated, centripetally advancing waves of irregular epithelium and subepithelial haze, originating from the upper aspect of the limbus. Identified risk factors included the use of topical antiglaucoma medications or contact lens care solutions, contact lens wear, past ocular surgery, acne rosacea, and atopic dermatitis. The condition was reported to respond to 1% silver nitrate applied to the superior aspect of the limbus. To our knowledge, no other cases have been documented. We describe a patient with advancing wavelike epitheliopathy and the confocal microscopic findings.