Ki-1–positive anaplastic large-cell lymphoma is an uncommon form of non-Hodgkin lymphoma. It lies within a spectrum of recently identified lymphoproliferative disorders. The entities within this spectrum share similar clinical and histopathologic characteristics that can make the diagnosis challenging. We report a case of Ki-1–positive anaplastic large-cell lymphoma involving the right upper eyelid of a 45-year-old woman and describe the light microscopic, immunohistochemical, and ultrastructural features. A pertinent review of the English-language literature is presented.