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Intravascular papillary endothelial hyperplasia (IPEH) is an unusual condition characterized by a benign proliferation of vascular endothelial cells that form papillary projections in the lumen of a blood vessel. It is not a specific neoplasm, but is generally believed to be a reactive response that develops secondary to a thrombus in vascular lesions such as varices or hemangiomas.1-3 It most often occurs as a painless, reddish purple lesion in the dermis or subcutis of the head and neck region or extremities.4-6 Intravascular papillary endothelial hyperplasia has been recognized to occur rarely in the ocular area, usually in the eyelid7-10 and less often in the orbit.9-11 In reported ocular cases, IPEH has occurred in association with a unilateral, solitary vascular lesion.7-11 We report a case of IPEH that developed in association with multiple bilateral orbital vascular tumors, thus expanding the known ocular spectrum of this condition.
Shields JA, Shields CL, Eagle RC, Diniz W. Intravascular Papillary Endothelial Hyperplasia With Presumed Bilateral Orbital Varices. Arch Ophthalmol. 1999;117(9):1247–1249. doi:https://doi.org/
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