[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Case Reports and Small Case Series
September 1999

Intravascular Papillary Endothelial Hyperplasia With Presumed Bilateral Orbital Varices

Arch Ophthalmol. 1999;117(9):1247-1249. doi:

Intravascular papillary endothelial hyperplasia (IPEH) is an unusual condition characterized by a benign proliferation of vascular endothelial cells that form papillary projections in the lumen of a blood vessel. It is not a specific neoplasm, but is generally believed to be a reactive response that develops secondary to a thrombus in vascular lesions such as varices or hemangiomas.1-3 It most often occurs as a painless, reddish purple lesion in the dermis or subcutis of the head and neck region or extremities.4-6 Intravascular papillary endothelial hyperplasia has been recognized to occur rarely in the ocular area, usually in the eyelid7-10 and less often in the orbit.9-11 In reported ocular cases, IPEH has occurred in association with a unilateral, solitary vascular lesion.7-11 We report a case of IPEH that developed in association with multiple bilateral orbital vascular tumors, thus expanding the known ocular spectrum of this condition.