[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 18.207.240.230. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
1.
Tieche  M Über benigne Melanome (Chromatophorome) der haut-blaue Naevi.  Virchows Arch Pathol Anat. 1906;186212- 229Google ScholarCrossref
2.
Dubreuilh  WPetges  G Le naevus bleu.  Ann Dermatol. 1911;2552- 556Google Scholar
3.
Lund  HZKraus  JM Melanotic tumors of the skin.  Atlas of Tumor Pathology Washington, DC Armed Forces Institute of Pathology1962;1 ((pt 3)) 108Google Scholar
4.
Jakobiec  FAZuckerman  BDBerlin  AJOdell  PMacRae  DWTuthill  RJ Unusual melanocytic nevi of the conjunctiva.  Am J Ophthalmol. 1985;100100- 113Google Scholar
5.
Johnson  BL Ocular combined nevus: report of a case of scleral blue nevus associated with a choroidal nevus.  Arch Ophthalmol. 1970;83594- 597Google ScholarCrossref
6.
Teekhasaenee  CRitch  R Glaucoma in phakomatosis pigmentovascularis.  Ophthalmology. 1997;104150- 157Google ScholarCrossref
7.
Boyd  ASRapini  RP Cutaneous collision tumors: an analysis of 69 cases and review of the literature.  Am J Dermatopathol. 1994;16252- 257Google ScholarCrossref
8.
Gartmann  HMüller  H Über das gemeinsame Vorkommen von blauem Naevus und Naevuszell-Naevus in ein und derselben Geschwulst ("combined nevus").  Z Hautkr. 1997;52389- 398Google Scholar
9.
Fletcher  VSagebiel  RW The combined nevus: mixed patterns of benign melanocytic lesions must be differentiated from malignant melanoma. Ackerman  ABed. Pathology of Malignant Melanoma New York, NY Masson Publishing1981;273- 284Google Scholar
10.
Pulitzer  DRMartin  PCCohen  APReed  RJ Histologic classification of the combined nevus: analysis of the variable expression of melanocytic nevi.  Am J Surg Pathol. 1991;151111- 1122Google ScholarCrossref
11.
Requena  LBarat  AHasson  A  et al.  Malignant combined nevus.  Am J Dematopathol. 1991;13167- 173Google Scholar
12.
Jakobiec  FAFolberg  RIwamoto  T Clinicopathologic characteristics of premalignant and malignant melanocytic lesions of the conjunctiva.  Ophthalmology. 1989;96147- 166Google ScholarCrossref
13.
Folberg  RJakobiec  FABernardino  VBIwamoto  T Benign conjunctival melanocytic lesions: clinicopathologic features.  Ophthalmology. 1989;96436- 461Google ScholarCrossref
Clinical Sciences
September 1999

Combined Nevi of the Conjunctiva

Author Affiliations

From the Department of Ophthalmology, University of California, San Francisco.

Arch Ophthalmol. 1999;117(9):1121-1127. doi:10.1001/archopht.117.9.1121
Abstract

Objective  To report the clinical and histologic features of combined nevi of the conjunctiva, a type of nevus that is not uncommon in the skin but rarely has been reported in the conjunctiva.

Methods  Conjunctival nevi and melanomas in the files of the University of California at San Francisco Eye Pathology Laboratory from 1984 to 1999 were reviewed for the presence of features of both standard nevocytic nevi and blue nevi. Clinical histories and, when available, clinical photographs were obtained.

Results  Thirty combined nevi were discovered between 1984 and 1999. One case before 1984 had been incorrectly diagnosed as a junctional nevus. The dendritic and spindle-shaped blue nevus cells had been overlooked because they were not recognized as distinct from the standard nevocytic nevus cells. The recognition of blue as well as a brown color, a deep as well as a superficial component in the lesion, or a history of pigmentation since birth may help to establish the correct clinical diagnosis and prevent an unnecessarily deep surgical resection. Although growth of the lesion or "satellites" in some may favor a clinical diagnosis of melanoma, no lesions in this series were malignant.

Conclusion  Despite a paucity of reports of combined nevi of the conjunctiva in the medical literature, this type of nevus, a combination of a nevocytic and a blue nevus, is common and has been overlooked in the past.

×