Acute Unilateral Corneal Immunoprotein Deposition in IgM Monoclonal Gammopathy | Allergy and Clinical Immunology | JAMA Ophthalmology | JAMA Network
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Clinicopathologic Report
January 2000

Acute Unilateral Corneal Immunoprotein Deposition in IgM Monoclonal Gammopathy

Author Affiliations

W. RICHARDGREENMDFrom the Department of Internal Medicine (Dr Schelonka) and Department of Surgery, Division of Ophthalmology (Dr Ogawa), University of New Mexico School of Medicine, Albuquerque; and the Department of Ophthalmology (Dr O'Brien) and Eye Pathology Laboratory (Dr Green), Wilmer Eye Institute, The Johns Hopkins University, Baltimore, Md.

Arch Ophthalmol. 2000;118(1):125-126. doi:10.1001/archopht.118.1.125

A healthy 43-year-old officer of a merchant ship at sea developed pain, redness, and photophobia in his right eye. During the next 2 weeks, he noted the presence of a band of opacity spreading from his temporal limbus toward his central cornea. His episcleral vessels were engorged in a distribution contiguous with the peripheral, sectorial, flecklike corneal opacities. The opacity had progressed during topical and systemic antibiotic therapy, but halted with use of topical corticosteroids. Systemic evaluation showed mild IgM monoclonal gammopathy. Transmission electron microscopy of a corneal biopsy specimen revealed electron-dense fibrils identified as immunoprotein. To our knowledge, this is the first report of a case of acute unilateral deposition of corneal immunoprotein in a patient with monoclonal gammopathy. Clinicians should begin with a broad differential diagnosis when evaluating patients with corneal opacity.