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Case Reports and Small Case Series
March 2000

Lipemia Retinalis in Acquired Immunodeficiency Syndrome Treated With Protease Inhibitors

Arch Ophthalmol. 2000;118(3):425-426. doi:

A 39-year-old man with human immunodeficiency virus infection developed cytomegalovirus retinitis in the right eye in 1995, necessitating treatment with foscarnet sodium. His CD4 cell count was 0.01 × 109/L (10/µL). His medications included zidovudine, lamivudine, trimethoprim-sulfamethoxazole, rifabutin, and acyclovir. Indinavir sulfate was added to his drug regimen in 1996. He had no history of diabetes mellitus, hypertension, or coronary artery disease. Findings from an examination in September 1996 revealed a macula-off retinal detachment in the right eye secondary to inactive cytomegalovirus retinitis. He underwent an uncomplicated right vitrectomy and silicone oil insertion in February 1997. The retina was attached postoperatively with atrophic macular changes resulting in poor vision. Retinal blood vessels were normal bilaterally. Because of a slowly climbing viral load to 162,000 copies per milliliter, the patient's antiviral therapy was changed in December 1997 to zalcitabine, ritonavir, saquinavir mesylate, and delavirdine mesylate.