Crossover Comparison of Timolol and Latanoprost in Chronic PrimaryAngle-closure Glaucoma | Glaucoma | JAMA Ophthalmology | JAMA Network
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Clinical Sciences
February 2004

Crossover Comparison of Timolol and Latanoprost in Chronic PrimaryAngle-closure Glaucoma

Author Affiliations

From the Dr Rajendra Prasad Centre for Ophthalmic Sciences, All IndiaInstitute of Medical Sciences, New Delhi, India. The authors have no relevantfinancial interest in this article.

Arch Ophthalmol. 2004;122(2):185-189. doi:10.1001/archopht.122.2.185

Objective  To compare latanoprost and timolol maleate as primary therapy in 60eyes with chronic primary angle-closure glaucoma after a laser iridotomy.

Methods  We performed a prospective, randomized, crossover study of 60 eyes of30 patients with chronic primary angle-closure glaucoma after laser iridotomy.Patients were randomized to 2 groups: those taking latanoprost once dailyor those taking timolol twice daily. Three months after treatment with thefirst drug, the second drug was substituted. The circadian rhythm of intraocularpressure (IOP) was recorded before the start of therapy, at 3 months, andat 7 months. The fourth month was the washout period for the first drug.

Results  The mean baseline IOP was 23.5 ± 2.1 mm Hg, which decreased by8.2 ± 2.0 mm Hg with latanoprost (P<.001)and by 6.1 ± 1.7 mm Hg with timolol (P = .01).The decrease in IOP was greater for patients taking latanoprost (P<.001). Latanoprost was significantly more effective in eyes havingmorning and afternoon peaks of IOP. A total of 43 eyes (72%) of patients takinglatanoprost and 26 (43%) on timolol achieved a reduction of more than 30%from baseline IOP.

Conclusion  There were greater mean and peak IOP reductions achieved with 0.005%latanoprost once daily compared with 0.5% timolol twice daily.