JAMA and the ARCHIVES journals will be participatingin the 2005 global theme issue, "Medical Applications of Biotechnology/RegenerativeMedicine, Tissue Engineering, Transplantation, Stem Cell Research." We inviteall investigators to submit their best research addressing issues in ophthalmologyfor consideration for the February 2005 issue. Manuscripts received by July1, 2004, have the best chance for acceptance for the global theme issue. Manuscriptsnot accepted for the theme issue may be considered for other issues of theARCHIVES. All manuscripts are subject to our usual peer review. Please notein the cover letter that the submission is for the February "Biotechnology"issue.