Palladium 103 (103Pd) Plaque Radiation Therapy for CircumscribedChoroidal Hemangioma With Retinal Detachment | Ophthalmic Imaging | JAMA Ophthalmology | JAMA Network
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Clinical Sciences
November 2004

Palladium 103 (103Pd) Plaque Radiation Therapy for CircumscribedChoroidal Hemangioma With Retinal Detachment

Author Affiliations

Author Affiliations: Departments of Ophthalmology,New York Eye Cancer Center (Drs Aizman and Finger), New York Eye and Ear Infirmary(Drs Shabto and Berson), and New York University School of Medicine (Drs Aizmanand Finger), and Department of Radiation Oncology, St Vincent’s ComprehensiveCancer Center (Drs Szechter and Berson), New York.

Arch Ophthalmol. 2004;122(11):1652-1656. doi:10.1001/archopht.122.11.1652

Objective  To describe clinical experience with palladium 103 (103Pd)ophthalmic plaque radiotherapy for choroidal hemangioma.

Methods  One course of 103Pd ophthalmic plaque radiotherapy was usedin each of 5 patients with circumscribed choroidal hemangioma who had progressiveloss of vision due to subretinal exudation. A mean apex dose of 2900 cGy (2900rad) was delivered. Functional tests of outcome included best-corrected visualacuity. Anatomic results included changes in tumor height and subretinal fluiddocumented by ophthalmoscopy, fluorescein angiography, and ultrasonography.

Results  All patients had complete resolution of subretinal fluid with reattachmentof the retina. All tumors decreased in height (mean, 50%) after treatment.Three patients (60%) demonstrated improvement in visual acuity at the lastfollow-up, and in 1 patient vision remained stable with resolution of metamorphopsia.Twenty-four months after treatment, 1 patient whose visual acuity had recoveredfrom 20/160 to 20/32 had a loss of vision to 20/160 because of radiation maculopathy.For all patients, a mean visual acuity improvement of 2 lines was documented(95% confidence interval, 0.23-0.88). Mean follow-up was 18.6 months (range,6-29 months).

Conclusions  A single 103Pd plaque radiation treatment was effective indecreasing tumor height, eliminating subretinal fluid, and improving visualacuity in patients with symptomatic circumscribed choroidal hemangiomas.