The Archives will be publishing a theme issue on ocular genetics to provide an overview of the status of this rapidly changing field. The issue will (1) include reviews of the genetics of major eye diseases, (2) provide insight into the current approaches and tools needed to evaluate findings from genetic studies (eg, statistical genetics and genetic epidemiology), (3) suggest how these tools will be used in the future to advance understanding of the etiology, pathogenesis, and treatment of different eye conditions, and (4) provide clinicians with some guidelines for communicating genetic risks to the average patient. The issue will include a combination of invited papers and papers presenting original research. Leslie Hyman, PhD, Janey Wiggs, MD, PhD, Barbara Klein, MD, MPH, and Barbara Nemesure, PhD, will be guest editors for this special issue. We invite and encourage all investigators to submit manuscripts describing original ocular genetics research by July 1, 2006. All manuscripts submitted for this issue are subject to an expedited peer review. Early receipt ensures the best chance for acceptance for this special issue. Accepted manuscripts not included in this issue will be published in other issues of the Archives. Please note in the cover letter that the submission is for the ocular genetics theme issue. The expected publication date for this issue is January 2007.