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Clinicopathologic Reports, Case Reports, and Small Case Series
April 2006

Pineal Cyst Simulating Pinealoblastoma in 11 Children With Retinoblastoma

Arch Ophthalmol. 2006;124(4):595-597. doi:10.1001/archopht.124.4.595

It is estimated that approximately 3% of all children with retinoblastoma and 5% to 15% of children with hereditary retinoblastoma will develop an intracranial neuroblastic malignancy, usually a pinealoblastoma (“trilateral retinoblastoma”).1-3 This malignancy typically appears in the first 5 years of life1-3 and is nearly always fatal when the patient has related symptoms.1-3 Therefore, children with retinoblastoma, especially those with hereditary retinoblastoma, are advised to have routine neuroimaging for the first 5 years of life with special attention to the pineal gland region.2,3 We recently encountered several retinoblastoma patients with a pineal cyst simulating pinealoblastoma, causing diagnostic and therapeutic confusion. For this reason, we reviewed our experience with this condition.