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It is estimated that approximately 3% of all children with retinoblastoma and 5% to 15% of children with hereditary retinoblastoma will develop an intracranial neuroblastic malignancy, usually a pinealoblastoma (“trilateral retinoblastoma”).1-3 This malignancy typically appears in the first 5 years of life1-3 and is nearly always fatal when the patient has related symptoms.1-3 Therefore, children with retinoblastoma, especially those with hereditary retinoblastoma, are advised to have routine neuroimaging for the first 5 years of life with special attention to the pineal gland region.2,3 We recently encountered several retinoblastoma patients with a pineal cyst simulating pinealoblastoma, causing diagnostic and therapeutic confusion. For this reason, we reviewed our experience with this condition.
Karatza EC, Shields CL, Flanders AE, Gonzalez ME, Shields JA. Pineal Cyst Simulating Pinealoblastoma in 11 Children With Retinoblastoma. Arch Ophthalmol. 2006;124(4):595–597. doi:10.1001/archopht.124.4.595
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