Relating Binocular and Monocular Vision in Strabismic and Anisometropic Amblyopia | Ophthalmology | JAMA Ophthalmology | JAMA Network
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Levi  DMKlein  S Differences in Vernier discrimination for grating between strabismic and anisometropic amblyopes.  Invest Ophthalmol Vis Sci 1982;23398- 407PubMedGoogle Scholar
Asper  LCrewther  DCrewther  SG Strabismic amblyopia: part 1: psychophysics.  Clin Exp Optom 2000;8349- 58PubMedGoogle ScholarCrossref
Eggers  HMBlakemore  C Physiological basis of anisometropic amblyopia.  Science 1978;201264- 267PubMedGoogle ScholarCrossref
Hess  RFHolliday  IE The spatial localization deficit in amblyopia.  Vision Res 1992;321319- 1339PubMedGoogle ScholarCrossref
Levi  DMKlein  S Hyperacuity and amblyopia.  Nature 1982;298268- 270PubMedGoogle ScholarCrossref
Sjostrand  J Contrast sensitivity in children with strabismic and anisometropic amblyopia: a study of the effect of treatment.  Acta Ophthalmol (Copenh) 1981;5925- 34PubMedGoogle ScholarCrossref
Levi  DMKlein  SA Limitations on position coding imposed by undersampling and univariance.  Vision Res 1996;362111- 2120PubMedGoogle ScholarCrossref
Hess  RFField  DJ Is the spatial deficit in strabismic amblyopia due to loss of cells or an uncalibrated disarray of cells?  Vision Res 1994;343397- 3406PubMedGoogle ScholarCrossref
Hess  RFAnderson  SJ Motion sensitivity and spatial undersampling in amblyopia.  Vision Res 1993;33881- 896PubMedGoogle ScholarCrossref
Holopigian  KBlake  RGreenwald  MJ Selective losses in binocular vision in anisometropic amblyopes.  Vision Res 1986;26621- 630PubMedGoogle ScholarCrossref
Chung  STLevi  DM Moving Vernier in amblyopic and peripheral vision: greater tolerance to motion blur.  Vision Res 1997;372527- 2533PubMedGoogle ScholarCrossref
Kubova  ZKuba  MJuran  JBlakemore  C Is the motion system relatively spared in amblyopia?.  Vision Res 1996;36181- 190PubMedGoogle ScholarCrossref
Sireteanu  RFronius  MSinger  W Binocular interaction in the peripheral visual field of humans with strabismic and anisometropic amblyopia.  Vision Res 1981;211065- 1074PubMedGoogle ScholarCrossref
McKee  SPLevi  DMMovshon  JA The pattern of visual deficits in amblyopia.  J Vis 2003;3380- 405PubMedGoogle ScholarCrossref
Legge  GE Spatial frequency masking in human vision: binocular interactions.  J Opt Soc Am 1979;69838- 847PubMedGoogle ScholarCrossref
Levi  DMHarwerth  RSSmith  EL  III Humans deprived of normal binocular vision have binocular interactions tuned to size and orientation.  Science 1979;206852- 854PubMedGoogle ScholarCrossref
Schor  CLandsman  LErickson  P Ocular dominance and the interocular suppression of blur in monovision.  Am J Optom Physiol Opt 1987;64723- 730PubMedGoogle ScholarCrossref
Harrad  RAHess  RF Binocular integration of contrast information in amblyopia.  Vision Res 1992;322135- 2150PubMedGoogle ScholarCrossref
Kiorpes  LMcKee  SP Neural mechanisms underlying amblyopia.  Curr Opin Neurobiol 1999;9480- 486PubMedGoogle ScholarCrossref
Brainard  DH The Psychophysics Toolbox.  Spatial Vision 1997;10433- 436PubMedGoogle ScholarCrossref
von Noorden  GKCampos  EC Examination of the patient, II: motor signs in heterophoria and heterotropia. In: Binocular Vision and Ocular Motility: Theory and Management of Strabismus. 6th St Louis, Mo Mosby–Yearbook Inc2002;chap 12
Carney  TShadlen  MN Dichoptic activation of the early motion system.  Vision Res 1993;331977- 1995PubMedGoogle ScholarCrossref
Shadlen  MCarney  T Mechanisms of human motion perception revealed by a new cyclopean illusion.  Science 1986;23295- 97PubMedGoogle ScholarCrossref
Holopigian  KBlake  RGreenwald  MJ Clinical suppression and amblyopia.  Invest Ophthalmol Vis Sci 1988;29444- 451PubMedGoogle Scholar
Pardhan  SGilchrist  J Binocular contrast summation and inhibition in amblyopia: the influence of the interocular difference on binocular contrast sensitivity.  Doc Ophthalmol 1992;82239- 248PubMedGoogle ScholarCrossref
Levi  DMCarkeet  A Amblyopia: a consequence of abnormal visual development. In:Simons  Ked. Early Visual Development, Normal and Abnormal.  Oxford, England Oxford University Press1993;391- 408
Levi  DMKlein  SA Vernier acuity, crowding and amblyopia.  Vision Res 1985;25979- 991PubMedGoogle ScholarCrossref
Norcia  AMTyler  CWHamer  RD Development of contrast sensitivity in the human infant.  Vision Res 1990;301475- 1486PubMedGoogle ScholarCrossref
Sharma  VLevi  DMKlein  SA Undercounting features and missing features: evidence for a high-level deficit in strabismic amblyopia.  Nat Neurosci 2000;3496- 501PubMedGoogle ScholarCrossref
Mussap  AJLevi  DM Binocular processes in Vernier acuity.  J Opt Soc Am A Opt Image Sci Vis 1995;12225- 233PubMedGoogle ScholarCrossref
Shimojo  SBirch  EEGwiazda  JHeld  R Development of Vernier acuity in infants.  Vision Res 1984;24721- 728PubMedGoogle ScholarCrossref
Crewther  DPCrewther  SG Neural site of strabismic amblyopia in cats: spatial frequency deficit in primary cortical neurons.  Exp Brain Res 1990;79615- 622PubMedGoogle ScholarCrossref
Sireteanu  RBest  J Squint-induced modification of visual receptive fields in the lateral suprasylvian cortex of the cat: binocular interaction, vertical effect and anomalous correspondence.  Eur J Neurosci 1992;4235- 242PubMedGoogle ScholarCrossref
Barnes  GRHess  RFDumoulin  SOAchtman  RLPike  GB The cortical deficit in humans with strabismic amblyopia.  J Physiol 2001;533281- 297PubMedGoogle ScholarCrossref
Imamura  KRichter  HFischer  H  et al.  Reduced activity in the extrastriate visual cortex of individuals with strabismic amblyopia.  Neurosci Lett 1997;225173- 176PubMedGoogle ScholarCrossref
Mendola  JDConner  IPRoy  A  et al.  Voxel-based analysis of MRI detects abnormal visual cortex in children and adults with amblyopia.  Hum Brain Mapp 2005;25222- 236PubMedGoogle ScholarCrossref
Skoczenski  AMNorcia  AM Late maturation of visual hyperacuity.  Psychol Sci 2002;13537- 541PubMedGoogle ScholarCrossref
Tychsen  L Binocular vision. In:Hart  Wed. Adler's Physiology of the Eye: Clinical Applications.  St Louis, Mo Mosby–Yearbook Inc1992;773- 853
Gwiazda  JBauer  JHeld  R From visual acuity to hyperacuity: a 10-year update.  Can J Psychol 1989;43109- 120PubMedGoogle ScholarCrossref
Lee  SYIsenberg  SJ The relationship between stereopsis and visual acuity after occlusion therapy for amblyopia.  Ophthalmology 2003;1102088- 2092PubMedGoogle ScholarCrossref
Birch  EEStager  DRBerry  PLeffler  J Stereopsis and long-term stability of alignment in esotropia.  J AAPOS 2004;8146- 150PubMedGoogle ScholarCrossref
Clinical Sciences
June 2006

Relating Binocular and Monocular Vision in Strabismic and Anisometropic Amblyopia

Author Affiliations

Author Affiliations: Departments of Neurobiology and Anatomy (Drs Agrawal, Conner, and Mendola), Ophthalmology (Drs Odom, Schwartz, and Mendola), and Radiology (Dr Mendola) and Center for Advanced Imaging (Dr Mendola), School of Medicine, West Virginia University, Morgantown.

Arch Ophthalmol. 2006;124(6):844-850. doi:10.1001/archopht.124.6.844

Objectives  To examine deficits in monocular and binocular vision in adults with amblyopia and to test the following 2 hypotheses: (1) Regardless of clinical subtype, the degree of impairment in binocular integration predicts the pattern of monocular acuity deficits. (2) Subjects who lack binocular integration exhibit the most severe interocular suppression.

Methods  Seven subjects with anisometropia, 6 subjects with strabismus, and 7 control subjects were tested. Monocular tests included Snellen acuity, grating acuity, Vernier acuity, and contrast sensitivity. Binocular tests included Titmus stereo test, binocular motion integration, and dichoptic contrast masking.

Results  As expected, both groups showed deficits in monocular acuity, with subjects with strabismus showing greater deficits in Vernier acuity. Both amblyopic groups were then characterized according to the degree of residual stereoacuity and binocular motion integration ability, and 67% of subjects with strabismus compared with 29% of subjects with anisometropia were classified as having “nonbinocular” vision according to our criterion. For this nonbinocular group, Vernier acuity is most impaired. In addition, the nonbinocular group showed the most dichoptic contrast masking of the amblyopic eye and the least dichoptic contrast masking of the fellow eye.

Conclusion  The degree of residual binocularity and interocular suppression predicts monocular acuity and may be a significant etiological mechanism of vision loss.