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Figure. 
Univariate sensitivity analysis. Change in estimated economic burden ($35.4 billion) associated with changes in specific parameters. AMD indicates age-related macular degeneration; NHIS, National Health Interview Study.

Univariate sensitivity analysis. Change in estimated economic burden ($35.4 billion) associated with changes in specific parameters. AMD indicates age-related macular degeneration; NHIS, National Health Interview Study.

Table 1. 
Estimated Number of Visual Disorder Patients Aged 40 to 64 Years and Cost per Patient*
Estimated Number of Visual Disorder Patients Aged 40 to 64 Years and Cost per Patient*
Table 2. 
Estimated Number of Visual Disorder Patients Aged 65 Years and Older and Cost per Patient*
Estimated Number of Visual Disorder Patients Aged 65 Years and Older and Cost per Patient*
Table 3. 
Total Direct Medical Costs of Visual Disorders Among US Adults by Age Category and Type of Disorder
Total Direct Medical Costs of Visual Disorders Among US Adults by Age Category and Type of Disorder
Table 4. 
Economic Burden of Visual Disorders Among US Adults Aged 40 Years or Older
Economic Burden of Visual Disorders Among US Adults Aged 40 Years or Older
Table 5. 
Governmental Budgetary Impact of Visual Disorders Among US Adults Aged 40 Years or Older
Governmental Budgetary Impact of Visual Disorders Among US Adults Aged 40 Years or Older
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The Eye Diseases Prevalence Research Group, The prevalence of refractive errors among adults in the United States, Western Europe, and Australia.  Arch Ophthalmol 2004;122495- 505PubMedGoogle ScholarCrossref
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Ellwein  LBUrato  CJ Use of eye care and associated charges among the medical population: 1991-1998.  Arch Ophthalmol 2002;120804- 811PubMedGoogle ScholarCrossref
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Hu  TW Economic Costs of Visual Disorders and Disabilities: United States, 1981.  US Dept of Health and Human Services, National Institutes of Health and National Eye Institute1982;
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Drummond  MO'Brien  BJStoddart  GLTorrance  GW Methods for the Economic Evaluation of Health Care Programmes. 2nd New York, NY Oxford University Press1999;
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MarketScan, MarketScan Commercial Claims and Encounter Data: 2001.  Ann Arbor, Mich Thomson Medstat2002;
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American Medical Association, International Classification of Diseases, 9th Revision, Clinical Modification.  Salt Lake City, Utah Medicode Publications1996;
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Lee  PPFeldman  ZWOstermann  JBrown  DSSloan  FA Longitudinal prevalence of major eye diseases.  Arch Ophthalmol 2003;1211303- 1310PubMedGoogle ScholarCrossref
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Sloan  FABrown  DSCarlisle  ESOstermann  JLee  PP Estimates of incidence rates with longitudinal claims data.  Arch Ophthalmol 2003;1211462- 1468PubMedGoogle ScholarCrossref
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Lee  PPFeldman  ZWOsterman  JBrown  DSSloan  FA Longitudinal rates of annual eye examinations of persons with diabetes and chronic eye diseases.  Ophthalmology 2003;1101952- 1959PubMedGoogle ScholarCrossref
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National Center for Health Statistics, National Ambulatory Medical Care Survey, 2002 [Public Use Data File and Documentation]. http://www.cdc.gov/nchs/about/major/ahcd/ahcd1.htmAccessed October 5, 2006
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National Center for Health Statistics, National Hospital Ambulatory Medical Care Survey, Outpatient Department File, 2002 [Public Use Data File and Documentation]. http://www.cdc.gov/nchs/about/major/ahcd/ahcd1.htmAccessed October 5, 2006
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Age-Related Eye Disease Study Research Group, A randomized, placebo-controlled clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report No. 8.  Arch Ophthalmol 2001;1191417- 1436PubMedGoogle ScholarCrossref
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Radimer  KBindewald  BHughes  JErvin  BSwanson  CPicciano  MF Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999–2000.  Am J Epidemiol 2004;160339- 349PubMedGoogle ScholarCrossref
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Wang  QKlein  BEKlein  RMoss  SE Refractive status in the Beaver Dam Eye Study.  Invest Ophthalmol Vis Sci 1994;354344- 4347PubMedGoogle Scholar
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Attebo  KIvers  RQMitchell  P Refractive errors in an older population: the Blue Mountains Eye Study.  Ophthalmology 1999;1061066- 1072PubMedGoogle ScholarCrossref
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Tielsch  JMSommer  AWitl  KKatz  JRoyall  RM Blindness and visual impairment in an American urban population.  Arch Ophthalmol 1990;108286- 290PubMedGoogle ScholarCrossref
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Doyle  JWSmith  MFTierney  JW Glaucoma medical treatment, 2002: does yearly cost now equal the year?  Optom Vis Sci 2002;79489- 492PubMedGoogle ScholarCrossref
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Fiscella  RGGreen  APatuszynski  DHWilensky  J Medical therapy cost considerations for glaucoma.  Am J Ophthalmol 2003;13618- 25PubMedGoogle ScholarCrossref
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Fiscella  RGGeller  JLGryz  LLWilensky  JViana  M Cost considerations of medical therapy for glaucoma.  Am J Ophthalmol 1999;128426- 433PubMedGoogle ScholarCrossref
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Fleming  Ted 2004 Red Book: Pharmacy's Fundamental Reference (Red Book Drug Topics). 108th Montvale, NJ Thomson Healthcare2004;
22.
National Center for Health Statistics, National Health and Nutrition Examination Survey (NHANES) III, 1997 [Public Use Data File and Documentation]. http://www.cdc.gov/nchs/about/major/nhanes/nh3data.htm#Data%20Files%201aAccessed October 5, 2006
23.
Tielsch  JMJavitt  JCColeman  AKatz  JSommer  A The prevalence of blindness and visual impairment among nursing home residents in Baltimore.  N Engl J Med 1995;3321205- 1209PubMedGoogle ScholarCrossref
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VanNewkirk  MRWeih  LMcCarty  CAStanislavsky  YLKeeffe  JETaylor  HR Visual impairment and eye diseases in elderly institutionalized Australians.  Ophthalmology 2000;1072203- 2208PubMedGoogle ScholarCrossref
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Gabrel  CS Characteristics of Elderly Nursing Home Current Residents and Discharges: Data From the 1997 National Nursing Home Survey, Advance Data From Vital and Health Statistics, No. 312.  Hyattsville, Md National Center for Health Statistics2000;
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Cooney  JLanders  GRein  DBae  JCurry  R Comparative Assessment of Cost and Care Outcomes Among Georgia's Community-Based and Facility-Based Long-term Care Programs.  Atlanta Georgia State University2004;
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U.S. Department of Education (DOE) Office of Special Education and Rehabilitative Services, Guide to education programs. http://web99.ed.gov/GTEP/Program2.nsfAccessed June 23, 2004
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McNeil  J Americans with Disabilities, 1997: Current Population Reports, Household Economic Studies.  Washington, DC US Census Bureau2001;
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US Census Bureau; Social Insurance and Human Services, Statistical abstract of the United States, supplemental security income: recipients and payments, 1980 to 2001 [Table 561].  Washington, DC Library of Congress2003;
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CCH Inc, U.S. Master Tax Guide.  Riverwoods, Ill Commerce Clearing House2003;
32.
Department of Agriculture, Food and Nutrition Service, Food stamp program: average monthly benefit per person, 2004. http://www.fns.usda.gov/pd/fsavgben.htmAccessed June 2004
33.
Centers for Medicare and Medicaid Services, An Overview of the U.S. Healthcare System: Two Decades of Change, 1980–2000, Chapter Three: Public Programs: Medicare, Medicaid, SCHIP. http://www.cms.hhs.gov/TheChartSeries/03_Facts_Figures_1980_2000.aspAccessed September 16, 2004
34.
US Census Bureau, Statistical Abstract of the United States: Resident Population by Age and Sex, 1980–1997 [Table 14].  Washington, DC Library of Congress2002;
35.
Centers for Medicaid and Medicare Services, Durable medical equipment, prosthetics/orthotics, and supplies (DMEPOS) fee schedule. http://www.cms.hhs.gov/DMEPOSFeeSched/LSDMEPOSFEE/list.aspAccessed October 5, 2006
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Guide Dog Users Inc, United States guide dog schools. http://www.gdui.orgAccessed October 5, 2006
37.
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38.
Agency for Healthcare Research and Quality,Rhoads The Uninsured in America, 2004: Estimates for the U.S. Civilian Noninstitutionalized Population Under Age 65 [Statistical Brief #83]. http://www.meps.ahrq.gov/data_stats/Pub_ProdResults_Details.jsp?pt=Statistical%20Brief&opt=2&id=692Accessed October 5, 2006
Socioeconomics and Health Services
December 2006

The Economic Burden of Major Adult Visual Disorders in the United States

Author Affiliations
 

PAUL P.LEEMDAuthor Affiliations: RTI International, Research Triangle Park, NC (Drs Rein, Wirth, Hoerger, and McCall); Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Division of Diabetes Translation, Atlanta, Ga (Drs Zhang and Saaddine); Duke University Center for Health Policy Law and Management, Durham, NC (Dr Lee); University of Wisconsin–Madison, Department of Ophthalmology and Visual Sciences, Madison (Dr Klein); Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Md (Dr Tielsch); University of Michigan, Veterans Affairs Health Services Research, Development Center for Practice Management and Outcomes Research, Ann Arbor (Dr Vijan).

Arch Ophthalmol. 2006;124(12):1754-1760. doi:10.1001/archopht.124.12.1754
Abstract

Objective  To estimate the societal economic burden and the governmental budgetary impact of the following visual disorders among US adults aged 40 years and older: visual impairment, blindness, refractive error, age-related macular degeneration, cataracts, diabetic retinopathy, and primary open-angle glaucoma.

Design  We estimated 3 components of economic burden: direct medical costs, other direct costs, and productivity losses. We used private insurance and Medicare claims data to estimate direct medical costs; epidemiologic evidence from multiple published sources to estimate other direct costs, such as nursing home costs; and data from the Survey of Income and Program Participation to estimate productivity losses. We used budgetary documents and our direct medical and other direct cost estimates to approximate the governmental budgetary impact.

Results  We estimated that the annual total financial burden of major adult visual disorders is $35.4 billion ($16.2 billion in direct medical costs, $11.1 billion in other direct costs, and $8 billion in productivity losses) and that the annual governmental budgetary impact is $13.7 billion.

Conclusions  Major visual disorders among Americans older than 40 years result in substantial economic costs for the US economy. Well-designed public health programs may have the ability to reduce this burden in the future.

In 2004, more than 3.6 million Americans suffered from visual impairment or blindness,1 and millions more experienced eye diseases or a refractive error correctable with glasses or contact lenses.2 Despite the wide impact of such visual disorders, few studies have evaluated the economic burden attributable to them, and those that have done so either estimated only 1 component of the cost for a particular age group3 or were conducted more than 20 years ago.4 In this article, we provide a current estimate of the societal cost of 4 major categories of visual disorders among US residents aged 40 years or older (who account for the majority of such disorders): (1) visual impairment; (2) blindness; (3) 4 ocular diseases—age-related macular degeneration (AMD), cataracts, diabetic retinopathy, and primary open-angle glaucoma—which account for roughly 75% of the cases of blindness and 85% of the cases of visual impairment among adults aged 40 years or older1; and (4) refractive errors (myopia and hyperopia), which account for a large additional component of financial burden.2

We estimated 3 components of costs related to visual disorders for 2004: direct medical costs, other direct costs necessitated by visual disorders, and productivity losses related to lower labor force participation of and lower wages earned by visually impaired workers.5 We also estimated the federal and state Medicaid budgetary impact of adult visual disorders by adding the portion of our burden estimate borne by the government to any additional amount of social welfare payments transferred from the federal treasury to people with visual impairment and blindness.

Methods
Direct medical costs

We used 2 sets of medical claims insurance data to estimate the number of patients using outpatient, inpatient, and prescription drug services, and the average annual per person cost for each service category for each disease. For those aged 40 to 64 years, we used claims data from 2 565 689 privately insured patients found in the 2001 MarketScan Commercial Claims and Encounters Research Database.6 For patients aged 65 years or older, we used 2000 Medicare claims data from a nationally representative sample of 167 993 fee-for-service beneficiaries selected to take part in the Consumer Assessment of Health Plans Survey.

Patient estimates

To estimate the number of patients using services for each disorder, we first identified all patients with at least 1 claim with a primary International Classification of Diseases, Ninth Revision, Clinical Modification7 diagnosis code for AMD, cataracts, diabetic retinopathy, and glaucoma using codes from previous research.8-10 We determined the number of patients aged 40 to 64 years who received services for each disorder by multiplying the number of patients seen in the MarketScan claims by 32.9 (the quotient of the full population of patients aged 40 to 64 years divided by the number of patients in MarketScan). We determined the number of patients aged 65 years or older who received services for each disorder using the data sampling weights with adjustments to account for unrepresented patients.

We only estimated prescription costs for glaucoma because prescriptions are not commonly used to treat other visual disorders. We estimated the number of patients aged 40 to 64 years using glaucoma medications in the same way we estimated other service categories except that we used National Drug Code numbers for identification in place of primary diagnosis codes. Because Medicare did not cover drugs in the observation period, we estimated the number of glaucoma prescriptions issued to patients aged 65 years and older using data from the 2002 National Ambulatory Medical Care Survey and from the National Hospital Ambulatory Medical Care Survey (outpatient department file) using a drug class variable to identify glaucoma prescriptions.11,12

Patients diagnosed with intermediate AMD may take nonprescription, antioxidant-plus-zinc vitamin supplements as a prophylactic therapy,13 which would not appear in claims data. No good estimate of the number of patients who take antioxidants plus zinc to treat AMD exists, although as many as 35% of American adults take multivitamins daily for any health reason.14 To conservatively estimate the cost of AMD multivitamins, we assumed that 5% of intermediate AMD patients aged 40 to 54 years, 10% of those aged 55 to 64 years, and 20% of those aged 65 years or older used vitamins according to clinical guidelines.

To estimate the total number of patients with refractive error, we multiplied the number of US residents aged 40 years or older in 2004 by the average proportion of those with hyperopia (spherical equivalence > + 0.5 diopters [D]) or myopia (spherical equivalence < − 0.5 D) found in 2 major population-based eye studies.15,16 We then subtracted the proportion of patients with uncorrected refractive error that were identified in the Baltimore Eye Study17 and assumed that patients change eyeglasses on average once every 3.4 years and change contacts annually.18

Average medical cost estimates

We estimated costs for outpatients aged 40 to 64 years by summing outpatient MarketScan claims with a primary diagnosis code for each condition per person; we then estimated the average annual cost per person per condition. We estimated outpatient and inpatient physician services and outpatient facility costs for patients aged 65 years or older similarly, using data from the Medicare physician and outpatient hospital files. The costs of inpatient services (a very small portion of total direct medical expenditures) were estimated in a similar manner.

We estimated the average annual cost per patient and average cost per claim of glaucoma medications18-20 by using MarketScan data.21 Average annual costs were used for people aged 40 to 64 years, and the average cost per claim was used for those aged 65 years or older. Because Medicare claims contained no information on prescriptions during this time period, we assumed that the average claim cost for patients aged 65 years or older was equal to the cost for patients aged 40 to 64 years. We estimated the cost of multivitamins for AMD as the lowest Internet price for the recommended vitamins when taken for 1 year.

We based refractive error costs on research indicating that, of people who use corrective devices, 93.5% use eyeglasses, 1.6% use contact lenses, and 4.9% use both.22 Eyeglass costs and ophthalmologic visits (1 visit per eyeglass or contact change) were assigned based on the Centers for Medicaid & Medicare Services fee schedule. The cost of fashionable frames or LASIK surgery was not estimated.

Other direct costs

We included the costs of nursing home care attributable to visual impairment, government purchase programs, and guide dogs for the blind in our estimate of other direct costs. To estimate nursing home placements attributable to visual impairment, we first estimated the total number of nursing home residents aged 65 years or older with vision impairment or blindness by multiplying the proportion of nursing home patients with visual impairment and blindness23,24 by the total number of nursing home patients.25 Second, we estimated the proportion of those aged 65 years or older with visual disorders who resided in nursing homes by dividing the number of nursing home patients estimated in step 1 by the total number of people with visual impairment or blindness. Third, we compared the proportions found in step 2 with the population proportion of people with normal vision residing in nursing homes to estimate the fraction of nursing home placements attributable to visual impairment and blindness.25 This additional incremental number of patients was multiplied by a previously published estimate of the annual costs of nursing home residence26 to estimate the costs of nursing home care attributable to visual impairment. We excluded the costs of residential care attributable to visual disorders because of insufficient information.

We considered the federally budgeted cost of 3 programs—the Department of Education's Independent Living Services for Older, Blind Individuals; the American Printing House for the Blind; and the Library of Congress' National Library Service for the Blind and Physically Handicapped—as other direct costs.27,28 We estimated the annual number of guide dog and person teams trained and the cost per team through a direct query of 10 of 12 certified training organizations reported by Guide Dog Users Inc.

Productivity losses

We defined productivity losses as the incremental costs of lower labor force participation and lower wages for visually impaired and blind individuals aged 40 to 64 years who worked compared with those in the same age group with normal vision. We used published analyses of data from the 1997 Survey of Income and Program Participation29 to estimate earnings and labor force participation, using an affirmative response to “Do you have some difficulty in seeing words or letters?” to indicate visual impairment and an affirmative response to “Do you have severe difficulty in seeing words or letters?” to indicate blindness. These analyses showed a labor force participation rate of 44% among the visually impaired and 30% among the blind, and average annual earnings of $23 345 among the visually impaired and $21 074 among the blind,29 compared with a labor force participation rate of nearly 85% and average annual earnings of $33 195 for those with normal vision. Because of insufficient information, we assumed no productivity losses associated with visual disorders for people older than 65 years.

Governmental budgetary impact

To estimate the overall impact of visual disorders on federal and state budgets, we added the annual cost of income assistance programs, tax losses, and the medical and other direct costs borne by taxpayers. To determine the cost of income assistance programs, we estimated the cost of Supplemental Security Income by multiplying the annual number of recipients eligible because of blindness by the average annual benefit amount,30 and we assumed that all those receiving Supplemental Security Income benefits also received federal food stamp benefits. To estimate the annual number of people receiving Social Security Disability Insurance because of visual disorders, we assumed that only those aged 40 to 64 years who were considered legally blind (visual acuity ≤20/200) were eligible for benefits. From this number of legally blind individuals, we subtracted those receiving Supplemental Security Income and those in the labor force.29 Of those remaining, we conservatively assumed that half received Social Security Disability Insurance benefits and multiplied that number by the annual benefit amount. We considered the cost of Social Security Disability Insurance and Supplemental Security Income to be transfer payments and therefore included them in our governmental burden estimate but not in our economic burden. We also included the small cost of the Committee for Purchase from People Who Are Blind or Severely Disabled as a federal transfer.

We calculated tax losses based on the standard income tax deduction for the blind31 and tax losses resulting from lower earnings and labor force participation assuming that annual productivity losses would have been taxed at the US average tax rate of 10.4%.32 We assumed that 80% of medical costs (excluding prescription drugs) for those aged 65 years or older were paid by Medicare and that Medicaid paid for 4.8% of care for individuals aged 40 to 64 years.29 Finally, we estimated the amount of visual disorder–attributable nursing home care paid for by the federal government by applying the proportion of all nursing home expenditures covered by Medicaid (nearly 51%) and Medicare (10%).33 We assumed that the federal government paid half of all Medicaid costs and that states paid the rest.

Sensitivity analysis

Our total burden estimate is sensitive to measurement error in the number of cases and unit costs of direct medical and other direct costs and to specific assumptions or choices made during the analysis. We evaluated the sensitivity of our estimate for (1) changes of ± 25% in our estimates of direct medical and other direct costs; (2) changes of ± 25% in the fraction of nursing home placements attributable to visual impairment and blindness; (3) the doubling of the cost of glasses replacement and varying the rate at which they are replaced; (4) the inclusion of 4 other conditions—conjunctivitis, strabismus, trauma, and uveitis (including these conditions could potentially increase our overall direct medical cost estimates by 15%)3; (5) the use of the older National Health Interview Study rather than the Survey of Income and Program Participation to estimate productivity losses; (6) our assumption that no medical services were used by uninsured patients; and (7) our assuming 0% and 100% use of multivitamins among eligible patients with AMD.

Results

For 2004, we estimated the total financial cost of major visual disorders among US residents aged 40 years or older at $35.4 billion: $16.2 billion in direct medical costs, $11.1 billion in other direct costs, and $8 billion in productivity losses. The direct medical costs for each condition were roughly $6.8 billion for cataracts, $5.5 billion for refractive error, $2.9 billion for glaucoma, $575 million for AMD, and $493 million for diabetic retinopathy (Table 1, Table 2, and Table 3). Outpatient and pharmaceutical services comprised the majority of direct medical costs, with inpatient costs accounting for virtually no costs.Refractive error accounted for the largest share of direct medical costs among those aged 40 to 64 years (46.2%), while cataracts accounted for the largest share among patients aged 65 years and older (56.2%). Across all ages, 75.6% of direct medical costs were attributable to cataracts and refractive error, with another 17.8% attributable to glaucoma.

The costs of AMD and cataracts were substantially higher among the population aged 65 years and older than in the population aged 40 to 64 years. In contrast, the costs of diabetic retinopathy, glaucoma, and refractive error were lower in the older age group than in the younger group. Increased overall costs for AMD and cataracts among patients aged 65 years and older were attributable to increased numbers of patients who use outpatient services for these conditions.

The lower overall diabetic retinopathy costs among patients older than 65 years compared with those aged 40 to 64 years were attributable in part to lower outpatient costs of care and in part to a lower number of cases in the older group. Lower glaucoma costs among patients 65 years and older were attributable to a lower rate of usage of prescription pharmaceuticals. More patients aged 65 years and older (3.0 million) sought outpatient services for glaucoma than patients aged 40 to 64 years (2.0 million), with roughly the same outpatient costs per person. However, the mean number of prescriptions filled for each patient using outpatient services fell from 9.8 among patients aged 40 to 64 years to 1.9 among patients aged 65 years and older (the cost per prescription was assumed to be the same for both groups). Lower refractive error costs among patients 65 years and older were attributable to a lower number of patients because of the smaller size of this age group.

We estimated that, among Americans aged 65 years or older, 16% of those who are visually impaired and 40% of those who are blind resided in nursing homes, compared with only 4.3% of those in the general population.34 From this, we estimated that 424 801 more visually impaired and blind Americans reside in nursing homes than would be expected if these same individuals had normal vision. Multiplying this value by the average annual cost of nursing home placement ($25 797),26 we estimated that visual impairment and blindness accounted for $11 billion in nursing home costs in 2004. Other direct costs included $94 million for government purchase programs and $62 million for guide dogs (Table 4).

For productivity losses, we estimated that 115 583 visually impaired and 74 133 blind people who did not work would have worked if fully sighted. Assuming the same average wage as for people with normal vision ($33 195), we estimated that reduced labor force participation by people with visual impairment and blindness accounted for $6.3 billion in lost productivity annually. Additionally, we estimated that 125 882 visually impaired and 40 671 blind people participated in the labor force but earned less than people with normal vision. Multiplying these numbers by the appropriate wage differential ($9851 for the visually impaired and $12 121 for the blind), we estimated productivity losses of $1.7 billion from decreased earnings.

In 2004, the total governmental budgetary impact of adult visual disorders was $13.7 billion (Table 5). Of this, the federal government paid $10.8 billion, and states paid an additional $2.9 billion in Medicaid matching funds. (Of this $13.7 billion total, $13.1 billion is included in our estimate of economic burden and an additional $0.59 billion results from transfer payments from one taxpayer to another.) Direct medical costs accounted for $5.5 billion of the budgetary impact; other direct costs accounted for $6.6 billion; and tax losses, transfer payments, and other government services accounted for $1.6 billion.

Our point estimates were most sensitive to possible measurement error in direct costs, the cost and rate of glasses replacement, and the fraction of nursing home placements attributable to visual impairment and blindness (Figure). Our estimates were relatively insensitive to the possible inclusion of omitted conditions, the use of alternative data to estimate productivity losses, the assumption of care for uninsured patients, and the percentage of patients with AMD who use vitamins.

Comment

We estimated that the total financial burden of major visual disorders among American adults was $35.4 billion in 2004: $16.2 billion in direct medical costs, $11.1 billion in other direct costs, and $8 billion in productivity losses. We estimated that these disorders cost the federal government and state Medicaid agencies at least $13.7 billion. This represents a conservative estimate of the total burden of major adult visual disorders, because we estimated only the costs of the disorders themselves and excluded the costs of associated comorbidities, such as depression and traumatic injury, as well as the cost of ophthalmic well-care for patients without a diagnosed disorder. The inclusion of these costs could have substantially increased our estimates.

Furthermore, many if not all of these costs should be expected to rise in the future as the US population ages and advances in medical science result in greater medical care use. For example, assuming no changes in the current age-specific disease prevalence or costs and treatments, such as the expanded use of drugs like injections of anecortave acetate suspension and pegaptanib sodium, we project the cost of AMD to increase from $575 million to $845 million during the next 15 years because of increases in the number of people older than 65 years. Similar trends may be expected for cataracts, glaucoma, and perhaps diabetic retinopathy. In addition, the recently enacted Medicare Part D reimbursement for prescription pharmaceuticals should lead to increased prescription use by patients with glaucoma aged 65 years and older. This study, which evaluated a time period prior to Medicare Part D, found dramatically lower prescription use by patients aged 65 years and older compared with patients aged 40 to 64 years.

This study was limited by a number of factors, many of which we attempted to account for in our sensitivity analysis. Prior research indicates that including omitted conditions such as conjunctivitis, strabismus, trauma, and uveitis could have increased our nonrefractive error direct medical cost estimates by as much as 15%.3

Our direct medical cost estimates included only the costs of any services whose primary International Classification of Diseases, Ninth Revision, Clinical Modification code was for a major adult visual disorder, regardless of whether the patient was diagnosed with the condition. Because we used only primary diagnoses, we may not have accounted for some services patients received during medical visits for other reasons. Also, the population from which the MarketScan data were collected is not representative of the general population because it does not include people on Medicaid and those who were uninsured. In 2004, 18.1% of Americans aged 35 to 54 years and 15.7% of those aged 55 to 64 years were uninsured,38 and these patients almost certainly consumed less ocular care than those represented in MarketScan.

Because of insufficient data, we assumed the age-specific proportion of patients who use prophylactic vitamin therapy for AMD. However, this assumption also had little impact on our final result because the relative burden of AMD is small. Our sensitivity analysis indicates that while increasing our vitamin use assumption to 100% for all eligible patients would increase our estimate of the cost of AMD by 22%, it would increase our total burden estimate by less than 1%. We assumed that the costs of glaucoma medications for patients younger than 65 years were the same as for Medicare patients aged 65 years or older.

In estimating nursing home costs, we excluded the costs of community-based assistance and informal care by family members. Readers should note that our study does not demonstrate a causal link between visual impairment and nursing home placement. Our attribution of nursing home costs to visual impairment and blindness is only valid to the extent that the higher than expected rate of nursing home residencies observed among visually impaired and blind people older than 65 years is in fact attributable to their condition. We also excluded the costs of over-the-counter rehabilitative equipment.

Our sensitivity analysis indicates that our total burden estimate is sensitive to uncertainty in our estimates of the quantity and costs of direct medical services generally, and the cost of correcting refractive error specifically, the fraction of nursing home placements attributable to visual impairment and blindness, and estimated productivity costs. We estimated direct medical costs with as much precision as possible and were able to validate our estimates against previously published studies,3 but a degree of estimation error is always possible. Our estimate of the cost of correcting refractive error depended heavily on the glasses replacement rate16 and on the cost of optical lenses and frames. Our estimate of productivity costs depended on the accuracy of the Survey of Income and Program Participation data used to estimate it and would have been $1.5 billion less had we used older National Health Interview Study data to calculate labor force participation levels.

After taking these limitations into account, this study still provides the most comprehensive, updated estimate of the burden of major adult visual disorders to date. Direct medical costs, the largest burden component, were measured with the greatest accuracy, and these costs are substantial. Furthermore, as the US population ages over the coming decades, the burden of adult visual disorders is likely to increase. Public health efforts to screen for and treat currently undiagnosed disease may be likely to increase direct medical care costs, but if effective, they will also improve visual outcomes, and potentially reduce productivity losses and nursing home placements associated with visual impairment and blindness. Interventions that prevent blindness, such as diagnosing early AMD and treating its progression with antioxidants plus zinc, or interventions to diagnose and treat uncorrected refractive error, have the potential to be highly cost-effective based on the improvements in patient quality of life they generate. Technological advancements that lead to reductions in the unit costs of glasses, cataract surgery, and medications to treat glaucoma have the potential to lead to substantial direct medical cost savings.

Correspondence: David B. Rein, PhD, RTI International, 2951 Flowers Rd, Suite 119, Atlanta, GA 30306 (drein@rti.org).

Submitted for Publication: December 27, 2005; final revision received May 17, 2006; accepted July 4, 2006.

Financial Disclosure: None reported.

Funding/Support: Funding for this research was provided by the Centers for Disease Control and Prevention's Division of Diabetes Translation through United States Federal Contract #200-2002-00776.

Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

Acknowledgment: The authors wish to acknowledge Leon B. Ellwein for his review and comments, Dr Kumiko Imai for data assistance, and would like to thank Lauren Mine and Susan Murchie for their editorial assistance.

References
1.
The Eye Diseases Prevalence Research Group, Causes and prevalence of visual impairment among adults in the United States.  Arch Ophthalmol 2004;122477- 485PubMedGoogle ScholarCrossref
2.
The Eye Diseases Prevalence Research Group, The prevalence of refractive errors among adults in the United States, Western Europe, and Australia.  Arch Ophthalmol 2004;122495- 505PubMedGoogle ScholarCrossref
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