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July 14, 2008

50 Years Ago in the Archives

Arch Ophthalmol. 2008;126(7):963. doi:10.1001/archopht.126.7.963

The steroids have become popular, as they are simpler to administer and occasion no discomfort to the patient. However, I believe the results with intravenous typhoid vaccine are immediately more dramatic and its use entails less expense to the patient. Many patients who have not responded to steroids have responded to the use of intravenous typhoid vaccine. Some patients will respond to one form of foreign-protein therapy and not to another. I recall 1 patient who developed uveitis after cataract extraction. Typhoid vaccine produced no effect but the eye became better after the first injection of milk. In another case of nongranulomatous iritis, the injection of typhoid vaccine did no good nor did the injection of milk, but the intramuscular injection of diphtheria antitoxin resulted in a prompt cure. . . . Since it takes 1 to 3 hours for fever to develop after a typhoid-vaccine injection, the treatment can be given in the office, which I have done for over 30 years.

Reference: Lebensohn JE. In discussion of: Nielsen RH, Kirby TJ. The modern treatment of uveitis. Arch Ophthalmol. 1957;58(1):100.