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Clinical Sciences
July 2010

Meta-analysis of the Efficacy and Safety of α2-Adrenergic Agonists, β-Adrenergic Antagonists, and Topical Carbonic Anhydrase Inhibitors With Prostaglandin Analogs

Author Affiliations

Author Affiliations: Departments of Ophthalmology (Dr Tanna) and Preventive Medicine (Dr Rademaker), Northwestern University Feinberg School of Medicine, Chicago, Illinois; and PRN Pharmaceutical Research Network, LLC, Dallas (Dr Stewart), and Department of Ophthalmology and Visual Science, University of Texas Health Science Center, Houston (Dr Feldman).

Arch Ophthalmol. 2010;128(7):825-833. doi:10.1001/archophthalmol.2010.131

Objective  To perform a meta-analysis to estimate the intraocular pressure (IOP)–lowering efficacy and safety of α2-adrenergic agonists (AAs), β-adrenergic antagonists (BBs), and topical carbonic anhydrase inhibitors (TCAIs) when used in combination with a prostaglandin analog (PGA).

Methods  MEDLINE, Embase, and the Cochrane Controlled Trials Register were systematically searched for relevant articles in April 2009. Ten observer-masked randomized clinical trials that reported baseline IOP while receiving PGA monotherapy and follow-up IOP while receiving combination therapy were identified. The pooled IOP-lowering efficacy achieved with each class of adjunctive agent was calculated using random-effects models. The frequencies of adverse events were pooled across studies and compared using Fisher exact test.

Results  Mean diurnal IOP reduction achieved in all 3 groups was statistically similar (P = .22). At trough, IOP reduction was greater in the TCAI (P < .001) and BB (P < .001) groups than in the AA group. Peak IOP reduction was similar in the 3 groups (P = .66). Eye or eyelid pain or burning and xerostomia were significantly more common in the AA group. Fatigue, weakness, or dizziness was more common in the AA and BB groups compared with the TCAI group. Taste disturbance was significantly more common in the TCAI group.

Conclusions  All 3 classes are similarly effective in lowering mean diurnal IOP when used in combination with PGAs. The AA class is statistically significantly less effective in reducing IOP at trough compared with BBs and TCAIs. The types of adverse events that were identified varied among the different classes of adjunctive therapies.