Upregulation of Interleukin 21 and Promotion of Interleukin 17 Production in Chronic or Recurrent Vogt-Koyanagi-Harada Disease | Infectious Diseases | JAMA Ophthalmology | JAMA Network
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Laboratory Sciences
November 8, 2010

Upregulation of Interleukin 21 and Promotion of Interleukin 17 Production in Chronic or Recurrent Vogt-Koyanagi-Harada Disease

Author Affiliations

Author Affiliations: Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou (Ms Li), The First Affiliated Hospital of Chongqing Medical University, Chongqing Eye Institute and Chongqing Key Laboratory of Ophthalmology, Chongqing (Mss Li and Wang and Drs Yang, Liu, and Hou), and Department of Ophthalmology, The Second Hospital of Jilin University, Changchun (Dr Liu), China; and Eye Research Institute Maastricht and Department of Ophthalmology, University Hospital Maastricht, Maastricht, the Netherlands (Dr Kijlstra).

Arch Ophthalmol. 2010;128(11):1449-1454. doi:10.1001/archophthalmol.2010.265
Abstract

Objectives  To analyze the expression and potential role of interleukin (IL) 21 in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease.

Methods  Blood samples were obtained from patients with VKH disease and from healthy control subjects. Serum IL-21 level and IL-21 messenger RNA (mRNA) expression by peripheral blood mononuclear cells (PBMCs) were determined by enzyme-linked immunosorbent assay and by reverse transcriptase–polymerase chain reaction, respectively. Interleukin 17 and interferon γ levels in the supernatants of PBMCs and CD4+ T cells cultured with anti-CD3 and anti-CD28 antibodies in the presence or absence of recombinant IL-21 were detected by enzyme-linked immunosorbent assay.

Results  The results showed a significantly increased serum IL-21 level, as well as higher IL-21 mRNA expression by PBMCs, in patients having chronic or recurrent active VKH disease compared with patients having inactive VKH disease and with controls. In vitro experiments showed that recombinant IL-21 significantly increased IL-17 production by PBMCs and by CD4+ T cells from patients and from controls. However, recombinant IL-21 did not affect interferon γ expression by PBMCs or by CD4+ T cells.

Conclusion  Interleukin 21 may be involved in the pathogenesis of chronic or recurrent VKH disease, possibly by promoting IL-17 secretion.

Clinical Relevance  Findings from the present study suggest that IL-21 may be a potential target in the development of therapy for VKH disease.

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