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February 2021 - January 1929

Decade

Year

Issue

March 2021, Vol 139, No. 3, Pages 268-366

Viewpoint

Express Medicine—Potential for Home-Based Medical Care

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):269-270. doi:10.1001/jamaophthalmol.2020.5981

This Viewpoint describes the potential for express medicine, a kind of telehealth involving the delivery and use of disease-monitoring equipment, such as optical coherence tomography machines, in a patient’s home.

Original Investigation

Evaluation of a Home-Printable Vision Screening Test for Telemedicine

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):271-277. doi:10.1001/jamaophthalmol.2020.5972

This diagnostic study evaluates the repeatability of vision measured using the Home Acuity Test and the agreement between the Home Acuity Test results and the last in-clinic visual acuity among ophthalmology outpatients in the United Kingdom.

Retinal Phenotype of Patients With Isolated Retinal Degeneration Due to CLN3 Pathogenic Variants in a French Retinitis Pigmentosa Cohort

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):278-291. doi:10.1001/jamaophthalmol.2020.6089

This case series provides a detailed description of the retinal phenotype of autosomal recessive nonsyndromic inherited retinal disease harboring biallelic CLN3 pathogenic variants.

Progression of Myopia in School-Aged Children After COVID-19 Home Confinement

Abstract Full Text
open access has active quiz
JAMA Ophthalmol. 2021;139(3):293-300. doi:10.1001/jamaophthalmol.2020.6239

This cross-sectional study compares the prevalence of myopia in school-aged children 5 years before the COVID-19 pandemic with the prevalence during home confinement due to the pandemic.

Association of Metformin Use With Age-Related Macular Degeneration: A Case-Control Study

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2021;139(3):302-309. doi:10.1001/jamaophthalmol.2020.6331

This case-control study uses a national database to assess whether metformin use is associated with reduced odds of developing age-related macular degeneration.

Association of a Health Coaching and Transportation Assistance Intervention at a Free Ophthalmology Homeless Shelter Clinic With Follow-up Rates

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):311-316. doi:10.1001/jamaophthalmol.2020.6373

This cohort study investigates the association of health coaching and transportation vouchers with follow-up rates at a free ophthalmology homeless shelter clinic.

Analysis of Pathogenic Variants Correctable With CRISPR Base Editing Among Patients With Recessive Inherited Retinal Degeneration

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):319-328. doi:10.1001/jamaophthalmol.2020.6418

This cross-sectional study uses data from the Oxford Medical Genetics Laboratory, the Leiden Open Variation Database, and previous studies to assess pathogenic single-nucleotide variants amenable to base editing in common recessive genes associated with inherited retinal degeneration.

Longitudinal Assessment of Retinal Thinning in Adults With and Without Sickle Cell Retinopathy Using Spectral-Domain Optical Coherence Tomography

Abstract Full Text
has audio
JAMA Ophthalmol. 2021;139(3):330-337. doi:10.1001/jamaophthalmol.2020.6525

This case-control study assesses the rates of retinal thinning in adults with and without sickle cell retinopathy using spectral-domain optical coherence tomography and examines ocular and systemic risk factors associated with retinal thinning.

Brief Report

Association of the Recurrent Rare Variant c.415T>C p.Phe139Leu in CLN5 With a Recessively Inherited Macular Dystrophy

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):339-343. doi:10.1001/jamaophthalmol.2020.6085

This cohort study describes the association between an autosomal recessive macular dystrophy with a recurrent variant in CLN5.

Visual Acuity Testing for Telehealth Using Mobile Applications

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):344-347. doi:10.1001/jamaophthalmol.2020.6177

This diagnostic study examines the accuracy and usability of visual acuity–testing apps available in the US Apple App Store.

Pediatric Eye Injuries by Hydroalcoholic Gel in the Context of the Coronavirus Disease 2019 Pandemic

Abstract Full Text
free access has active quiz
JAMA Ophthalmol. 2021;139(3):348-351. doi:10.1001/jamaophthalmol.2020.6346

This study investigates the potential increase of pediatric eye exposures to alcohol-based hand sanitizer since the start of the coronavirus disease 2019 pandemic.

Invited Commentary

Hereditary Systemic Diseases Can Have a Predominant Ocular Phenotype, but They Are Still Systemic Diseases

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):291-292. doi:10.1001/jamaophthalmol.2020.6105

2020 as the Year of Quarantine Myopia

Abstract Full Text
free access has audio
JAMA Ophthalmol. 2021;139(3):300-301. doi:10.1001/jamaophthalmol.2020.6231

Is There a Case for Case-Control Studies in the Exploration of Retrospective Data Sets?

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):309-310. doi:10.1001/jamaophthalmol.2020.6328

Moving From Just “Thinking Outside the Box” to Doing

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):317-318. doi:10.1001/jamaophthalmol.2020.6374

Strategies for Treating Inherited Retinal Degeneration With Large Genes That Are Not Amenable to Adeno-Associated Virus–Based Gene Replacement Therapy

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):328-329. doi:10.1001/jamaophthalmol.2020.6427

Sickle Cell Disease and the Eye—Everything Old Is New Again

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):337-338. doi:10.1001/jamaophthalmol.2020.6526

Limitations of Measuring Visual Acuity With Remote Applications

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):347. doi:10.1001/jamaophthalmol.2020.6155

Unintended Consequences of Hand Sanitizer Use in the Coronavirus Disease 2019 Pandemic

Abstract Full Text
free access has active quiz
JAMA Ophthalmol. 2021;139(3):352. doi:10.1001/jamaophthalmol.2020.6327
JAMA Ophthalmology Clinical Challenge

Worsening Floaters in a 68-Year-Old White Woman

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2021;139(3):353-354. doi:10.1001/jamaophthalmol.2020.4612

An elderly white woman presents with floaters and decreased visual acuity in both eyes as well as trigeminal neuralgia. What would you do next?

A Nonhealing Epithelial Defect in a Patient Experiencing Alcohol Use Disorder

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2021;139(3):355-356. doi:10.1001/jamaophthalmol.2020.4651

A patient presents with ongoing alcohol use disorder and an epithelial defect that grows despite treatment. What would you do next?

Orbital Swelling in a Child With Retinoblastoma Following Intra-arterial Chemotherapy

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2021;139(3):357-358. doi:10.1001/jamaophthalmol.2020.4675

A 9-month-old girl presented to the emergency department with significant left periocular edema and erythema 3 days after receiving intra-arterial chemotherapy. Computed tomography scan of the orbits demonstrated preseptal and periorbital soft tissue swelling and edema with subtle retrobulbar stranding, without substantial proptosis, along with retinal detachment. What would you do next?

Bilateral Enlargement of All Extraocular Muscles

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2021;139(3):359-360. doi:10.1001/jamaophthalmol.2020.4679

A 64-year-old woman presented with 27 mm of bilateral proptosis, conjunctival injection, lower eyelid retraction, and free extraocular movements. An orbital computed tomography scan revealed marked enlargement of every extraocular muscle. What would you do next?

Research Letter

Adapting to Coronavirus Disease 2019 With Point-of-Care Outdoor Intraocular Pressure Monitoring

Abstract Full Text
free access has active quiz
JAMA Ophthalmol. 2021;139(3):361-362. doi:10.1001/jamaophthalmol.2020.6073

This cohort study describes data from a drive-through clinic designed to measure intraocular pressure while maintaining patient safety during the coronavirus disease 2019 pandemic.

Observation

Hand Sanitizer–Induced Ocular Injury: A COVID-19 Hazard in Children

Abstract Full Text
free access has active quiz
JAMA Ophthalmol. 2021;139(3):362-364. doi:10.1001/jamaophthalmol.2020.6351

This case report describes 2 cases of toxic keratopathy in children after unintentional contact between alcohol-based hand rubs and the eye.

Ophthalmic Images

Cerebral Cavernous Malformation 2 Syndrome Presenting With Retinal Cavernous Hemangioma and Sixth Cranial Nerve Palsy

Abstract Full Text
online only
JAMA Ophthalmol. 2021;139(3):e204104. doi:10.1001/jamaophthalmol.2020.4104

This case report describes a middle-aged woman with left-sided retro-orbital pain and horizontal binocular diplopia after initiating in vitro fertilization, associated with a pathogenic genetic variant.

Papilledema With Intraretinal and Preretinal Hemorrhage

Abstract Full Text
online only
JAMA Ophthalmol. 2021;139(3):e205306. doi:10.1001/jamaophthalmol.2020.5306

This case report describes a middle-aged woman who experienced papilledema with intraretinal and preretinal hemorrhage in both eyes, secondary to a glioblastoma.

Hyperlipofuscinosis With Subretinal Fibrosis and Choroidal Vascular Remodeling in Stargardt Disease

Abstract Full Text
online only
JAMA Ophthalmol. 2021;139(3):e205438. doi:10.1001/jamaophthalmol.2020.5438

This case report describes stable ophthalmic abnormalities visible on examination and imaging in a boy with ABCA4-associated Stargardt disease.

Unilateral Pseudoexfoliation Deposits on an Intraocular Lens

Abstract Full Text
online only
JAMA Ophthalmol. 2021;139(3):e206856. doi:10.1001/jamaophthalmol.2020.6856

This case report describes unilateral pseudoexfoliation deposits on the anterior surface of the intraocular lens of an elderly patient.

Comment & Response

Long-term Macular Effects of Pentosan Polysulfate Sodium Exposure Uncertain—Let’s Not Jump to Conclusions

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):364. doi:10.1001/jamaophthalmol.2020.6615

Long-term Macular Effects of Pentosan Polysulfate Sodium Exposure Uncertain—Let’s Not Jump to Conclusions—Reply

Abstract Full Text
JAMA Ophthalmol. 2021;139(3):364-365. doi:10.1001/jamaophthalmol.2020.6618

Specifying the Role of Masks in Reducing Viral Material on Environmental Surfaces of an Ophthalmology Examination Room

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(3):365-366. doi:10.1001/jamaophthalmol.2020.6565

Specifying the Role of Masks in Reducing Viral Material on Environmental Surfaces of an Ophthalmology Examination Room—Reply

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(3):366. doi:10.1001/jamaophthalmol.2020.6568
Correction

Error in Figure 1 and Additional Information

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(3):366. doi:10.1001/jamaophthalmol.2020.5934
JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
free access
JAMA Ophthalmol. 2021;139(3):268. doi:10.1001/jamaophthalmol.2020.3749
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