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June 13, 2011, Vol 129, No. 6, Pages 689-820

Editorial

Ocular Hypertension and Normal-Tension Glaucoma: Time for Banishment and Burial

Abstract Full Text
Arch Ophthalmol. 2011;129(6):785-787. doi:10.1001/archophthalmol.2011.117
Research Letter

Complete, Pupil-Sparing Third Nerve Palsy in a Patient With a Malignant Peripheral Nerve Sheath Tumor

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.122

Three-Dimensional Reconstruction and Analysis of Vitreomacular Traction: Quantification of Cyst Volume and Vitreoretinal Interface Area

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.123

Subclinical Facioscapulohumeral Muscular Dystrophy Masquerading as Bilateral Coats Disease in a Woman

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.124

Posterior Microphthalmos as a Genetically Heterogeneous Condition That Can Be Allelic to Nanophthalmos

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.129

Commercial Air Travel With a Small Intravitreous Gas Bubble

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.144
Ophthalmic Images

Retinal Pigment Epithelial Tear in Vogt-Koyanagi-Harada Disease

Abstract Full Text
Arch Ophthalmol. 2011;129(6):780. doi:10.1001/archophthalmol.2011.127
Ophthalmological Numismatics

Alfred Terson

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Arch Ophthalmol. 2011;129(6):790. doi:10.1001/archophthalmol.2011.121
Clinical Sciences

Corneal Transplantation for Keratoconus: A Registry Study

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Arch Ophthalmol. 2011;129(6):691-697. doi:10.1001/archophthalmol.2011.7
ObjectiveTo determine factors influencing long-term graft survival and visual acuity in 4834 eyes of 4060 patients receiving their first penetrating corneal graft for keratoconus.MethodsA large cohort study was performed from a national register of corneal grafts in which data were recorded prospectively and analyzed retrospectively. Main outcome measures were graft survival and Snellen visual acuity. Follow-up extended up to 23 years.ResultsKaplan-Meier survival rates of first grafts for keratoconus were 89%, 49%, and 17% at 10, 20, and 23 years, respectively. After 15 years, the graft survival rate was no better than that of all other penetrating grafts (P = .36). Multivariate risk factors influencing failure of first grafts for keratoconus included time to suture removal, postgraft uveitis or microbial keratitis, corneal vascularization prior to or after graft, geographic location of surgery and follow-up (center effect), recipient age at graft, occurrence of rejection episodes, graft size, and surgeon workload. The timing of bilateral grafts made no difference to the risk of rejection. A Snellen visual acuity of 20/40 or better at the most recent follow-up was recorded in 74% of grafts.ConclusionsPenetrating grafts performed for keratoconus exhibited better visual outcome and graft survival than grafts performed for other indications. However, the Kaplan-Meier survival rate of first penetrating grafts for keratoconus was 17% at 23 years after graft and had not plateaued at this time, indicating that young patients are likely to need 1 or more repeated grafts during their lifetime.

Surgeon's Corner

Intraocular Pressure Response to Selective Laser Trabeculoplasty in the First Treated Eye vs the Fellow Eye

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Arch Ophthalmol. 2011;129(6):699-702. doi:10.1001/archophthalmol.2011.108

Intraocular Pressure Response to Selective Laser Trabeculoplasty in the First Treated Eye vs the Fellow Eye

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Arch Ophthalmol. 2011;129(6):699-702. doi:10.1001/archophthalmol.2011.108
Archives Web Quiz Winner

January 2011 Archives Web Quiz Winner

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Arch Ophthalmol. 2011;129(6):702. doi:10.1001/archophthalmol.2011.103

Foveal Damage in Habitual Poppers Users

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Arch Ophthalmol. 2011;129(6):703-708. doi:10.1001/archophthalmol.2011.6

Foveal Damage in Habitual Poppers Users

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Arch Ophthalmol. 2011;129(6):703-708. doi:10.1001/archophthalmol.2011.6

Journal Club

Estimated Cases of Legal Blindness and Visual Impairment Avoided Using Ranibizumab for Choroidal Neovascularization: Non-Hispanic White Population in the United States With Age-Related Macular Degeneration

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Arch Ophthalmol. 2011;129(6):709-717. doi:10.1001/archophthalmol.2011.140

Estimated Cases of Legal Blindness and Visual Impairment Avoided Using Ranibizumab for Choroidal Neovascularization: Non-Hispanic White Population in the United States With Age-Related Macular Degeneration

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Arch Ophthalmol. 2011;129(6):709-717. doi:10.1001/archophthalmol.2011.140

Comparison of Digital and Film Grading of Diabetic Retinopathy Severity in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

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Arch Ophthalmol. 2011;129(6):718-726. doi:10.1001/archophthalmol.2011.136

Evolution in Regression Patterns Following Chemoreduction for Retinoblastoma

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Arch Ophthalmol. 2011;129(6):727-730. doi:10.1001/archophthalmol.2011.137

Intra-arterial Chemotherapy for the Management of Retinoblastoma: Four-Year Experience

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Arch Ophthalmol. 2011;129(6):732-737. doi:10.1001/archophthalmol.2011.5
ObjectiveTo determine whether intra-arterial chemotherapy is safe and effective in advanced intraocular retinoblastoma. Retinoblastoma often presents with advanced intraocular disease and, despite conventional treatment with intravenous chemotherapy and external beam radiation therapy, may still require enucleation.DesignSingle-arm, prospective registry from May 30, 2006, to May 30, 2010, at an ophthalmic oncology referral center with ambulatory care. A total of 95 eyes of 78 patients with unilateral or bilateral retinoblastoma were treated. The intervention was selective catheterization of the ophthalmic artery and injection of chemotherapy, usually melphalan with or without topotecan. Drug dosage was determined by age and angioanatomy. The main outcome measures were procedural success, event-free (enucleation or radiotherapy) ocular survival, and ocular and extraocular complications.ResultsCatheterization succeeded in 98.5% of procedures. There were 289 chemotherapy injections (median, 3 per eye). The Kaplan-Meier estimates of ocular event-free survival rates at 2 years were 70.0% (95% confidence interval, 57.9%-82.2%) for all eyes, 81.7% (95% confidence interval, 66.8%-96.6%) for eyes that received intra-arterial chemotherapy as primary treatment, and 58.4% (95% confidence interval, 39.5%-77.2%) for eyes that had previous treatment failure with intravenous chemotherapy and/or external beam radiation therapy. There were no permanent extraocular complications.ConclusionOur experience suggests that intra-arterial chemotherapy is safe and effective in the treatment of advanced intraocular retinoblastoma.

Periocular Topotecan for Intraocular Retinoblastoma

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Arch Ophthalmol. 2011;129(6):738-745. doi:10.1001/archophthalmol.2011.130

Phacomatosis Pigmentovascularis of Cesioflammea Type in 7 Patients: Combination of Ocular Pigmentation (Melanocytosis or Melanosis) and Nevus Flammeus With Risk for Melanoma

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Arch Ophthalmol. 2011;129(6):746-750. doi:10.1001/archophthalmol.2011.135
Laboratory Sciences

Influence of Elevated Intraocular Pressure on the Posterior Chamber–Anterior Hyaloid Membrane Barrier During Cataract Operations

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Arch Ophthalmol. 2011;129(6):751-757. doi:10.1001/archophthalmol.2011.115
Epidemiology

Reducing the Genetic Risk of Age-Related Macular Degeneration With Dietary Antioxidants, Zinc, and ω-3 Fatty Acids: The Rotterdam Study

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Arch Ophthalmol. 2011;129(6):758-766. doi:10.1001/archophthalmol.2011.141

Reducing the Genetic Risk of Age-Related Macular Degeneration With Dietary Antioxidants, Zinc, and ?-3 Fatty Acids: The Rotterdam Study

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Arch Ophthalmol. 2011;129(6):758-766. doi:10.1001/archophthalmol.2011.141

Lifestyle and Risk of Developing Open-Angle Glaucoma: The Rotterdam Study

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Arch Ophthalmol. 2011;129(6):767-772. doi:10.1001/archophthalmol.2010.373
ObjectiveTo determine whether lifestyle-related risk factors, such as socioeconomic status, smoking, alcohol consumption, and obesity, are associated with open-angle glaucoma (OAG).MethodsParticipants from the Rotterdam Study, a prospective population-based cohort study, were considered eligible if they participated at both baseline and follow-up and if they had no OAG at baseline. All participants underwent an identical ophthalmologic examination at all visits, including intraocular pressure measurements, optic nerve head assessment, and perimetry. Lifestyle-related factors were assessed by questionnaires by trained research assistants or measured during the examinations (body mass index and waist to hip ratio). Cox proportional hazard regression analysis was applied to calculate hazard ratios.ResultsOf 3939 eligible participants, 108 (2.7%) developed OAG during 9.7 years' mean follow-up. No statistically significant effect of socioeconomic status, smoking, or alcohol intake was found. In women, each unit increase in body mass index resulted in a 7% decrease in the risk of developing OAG (P = .04). There was a significant increasing effect of body mass index on intraocular pressure (P < .001) in women.ConclusionsObesity appears to be associated with a higher intraocular pressure and a lower risk of developing OAG. These associations were only present in women. Other lifestyle-related factors, such as socioeconomic status, smoking, and alcohol consumption, were not associated with OAG.

Endothelial Nitric Oxide Synthase Gene Variants and Primary Open-Angle Glaucoma: Interactions With Hypertension, Alcohol Intake, and Cigarette Smoking

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Arch Ophthalmol. 2011;129(6):773-780. doi:10.1001/archophthalmol.2011.118

Endothelial Nitric Oxide Synthase Gene Variants and Primary Open-Angle Glaucoma: Interactions With Hypertension, Alcohol Intake, and Cigarette Smoking

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Arch Ophthalmol. 2011;129(6):773-780. doi:10.1001/archophthalmol.2011.118
Ophthalmic Molecular Genetics

Oculodentodigital Dysplasia: New Ocular Findings and a Novel Connexin 43 Mutation

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Arch Ophthalmol. 2011;129(6):781-784. doi:10.1001/archophthalmol.2011.113

Oculodentodigital Dysplasia: New Ocular Findings and a Novel Connexin 43 Mutation

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Arch Ophthalmol. 2011;129(6):781-784. doi:10.1001/archophthalmol.2011.113
Commentary

Importance of the NHANES 2005-2008 Diabetic Retinopathy Data

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Arch Ophthalmol. 2011;129(6):788-790. doi:10.1001/archophthalmol.2011.125
Special Article

The First Western-Style Hospital in China

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Arch Ophthalmol. 2011;129(6):791-797. doi:10.1001/archophthalmol.2011.120

The First Western-Style Hospital in China

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Arch Ophthalmol. 2011;129(6):791-797. doi:10.1001/archophthalmol.2011.120
Small Case Series

Ocular Surface Disease Secondary to Vitamin A Deficiency in the Developed World: It Still Exists

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Arch Ophthalmol. 2011;129(6):798-804. doi:10.1001/archophthalmol.2011.126

Spontaneous Regression of Small Melanocytic Choroidal Tumor

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Arch Ophthalmol. 2011;129(6):798-804. doi:10.1001/archophthalmol.2011.128

Retinal Dystrophy in 2 Brothers With α-Mannosidosis

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Arch Ophthalmol. 2011;129(6):798-804. doi:10.1001/archophthalmol.2011.134
Letters

Vitamin E and Age-Related Cataracts

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.106

Vitamin E and Age-Related Cataracts

Abstract Full Text
Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.106

Vitamin E and Age-Related Cataracts—Reply

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.107

Vitamin E and Age-Related Cataracts—Reply

Abstract Full Text
Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.107

Immune Choroiditis Following Acute Retinal Necrosis

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.109

Immune Choroiditis Following Acute Retinal Necrosis

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.109

Immune Choroiditis Following Acute Retinal Necrosis—Reply

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.110

Immune Choroiditis Following Acute Retinal Necrosis—Reply

Abstract Full Text
Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.110

Norrie Disease vs Familial Exudative Vitreoretinopathy

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.131

Norrie Disease vs Familial Exudative Vitreoretinopathy

Abstract Full Text
Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.131

Cystic Macular Lesions in Patients With Retinitis Pigmentosa

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.132

Cystic Macular Lesions in Patients With Retinitis Pigmentosa

Abstract Full Text
Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.132

Cystic Macular Lesions in Patients With Retinitis Pigmentosa—Reply

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.133

Cystic Macular Lesions in Patients With Retinitis Pigmentosa—Reply

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.133

Ocular Adnexal IgG4-Related Lymphoplasmacytic Infiltrative Disorder and Graves Ophthalmopathy

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.138

Ocular Adnexal IgG4-Related Lymphoplasmacytic Infiltrative Disorder and Graves Ophthalmopathy

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.138

Ocular Adnexal IgG4-Related Lymphoplasmacytic Infiltrative Disorder and Graves Ophthalmopathy—Reply

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.139

Ocular Adnexal IgG4-Related Lymphoplasmacytic Infiltrative Disorder and Graves Ophthalmopathy—Reply

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.139

Natamycin and Voriconazole in Fungal Keratitis

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.97

Natamycin and Voriconazole in Fungal Keratitis

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.97

Natamycin and Voriconazole in Fungal Keratitis—Reply

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.98

Natamycin and Voriconazole in Fungal Keratitis—Reply

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Arch Ophthalmol. 2011;129(6):805-820. doi:10.1001/archophthalmol.2011.98
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