Kadonosono et al developed a new surgical treatment in which a microneedle is used for retinal endovascular cannulation to treat eyes with central retinal vein occlusion by flushing thrombus out of the central retinal vein as it passes through the lamina cribrosa. The eyes of 12 consecutive patients were successfully treated using this technique.
Amparo et al performed a 16-week randomized clinical trial to evaluate the efficacy of treatment with the topical interleukin 1 (IL-1) receptor antagonist anakinra in patients having dry eye disease related to meibomian gland dysfunction.
In a phase 3 trial, Katz et al evaluated the efficacy and safety of fixed-combination brinzolamide, 1%, and brimonidine, 0.2%, compared with those of each component administered separately in 660 patients with open-angle glaucoma or ocular hypertension.
Sejpal and coauthors report the outcomes of autologous ex vivo cultivated limbal epithelial transplantation in pediatric patients undergoing limbal stem cell deficiency after ocular burns.
Alio et al evaluate use of autologous solid platelet-rich plasma in combination with an autologous fibrin membrane placed over the corneal surface as a temporary intervention in 11 patients with corneal perforation.
Patel et al describe presentations and outcomes of mycobacterial ocular disease in the Midwestern United States.
To ascertain whether subcortical visual input contributes to the asymmetrical monocular optokinetic responses that characterize infantile esotropia, Brodsky and Klaehn performed the optokinetic uncover test in 7 patients with isolated infantile esotropia and in 3 patients with infantile esotropia syndrome associated with mild neurological disease.
Schmidt et al test the hypotheses that lubricin is produced by ocular surface epithelia and acts to protect the cornea and conjunctiva against significant shear forces generated during an eyelid blink and that lubricin deficiency increases shear stress on the ocular surface and promotes corneal damage.
Ahmed et al correlate optical coherence tomography findings and severity of temporal macular thinning with COL4A5 mutations in a cohort with X-linked Alport syndrome.
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