December 2014, Vol 132, No. 12, Pages 1389-1493

Robitaille et al identify gene mutations in patients who present with an familial exudative vitreoretinopathy (FEVR) phenotype and explore the spectrum of ocular and systemic abnormalities caused by KIF11 mutations in a cohort of patients with FEVR or microcephaly in conjunction with chorioretinopathy or FEVR.

Christ et al evaluate the direct and indirect effects of change in visual acuity loss on mortality risk through functional status changes among aging adults.

Kim and colleagues evaluate the diagnostic ability of a novel screening modality, the crescent moon sign (defined as the discontinuity between the superior or inferior optic rim margin and the temporal optic rim margin) for the detection of glaucomatous eyes with myopic tilted discs.

Lin and coauthors investigate the association between serum ferritin and glaucoma in the South Korean population.

Guedj and coauthors assess the occurrence and severity of uveitis as an adverse effect of vemurafenib therapy

Rehnman et al perform an in vivo study to quantify the biomechanical effects of corneal collagen crosslinking.

This randomized clinical trial suggests that drug-induced mydriasis can help in identifying eyes with pigment dispersion syndrome that are at risk for progressing to ocular hypertension. Nd:YAG laser peripheral iridotomy, when performed at the appropriate time and on high-risk eyes showing a concave iris root, can be protective over the long term.

This clinic-based case-control study conducted in the United States and Israel reports that lifetime outdoor activities, as related to geographic location and the extent of solar exposure, may contribute to exfoliation syndrome.

This cohort study evaluates risk factors for nonpersistence among patients in Taiwan with open-angle glaucoma and ocular hypertension and suggests that factors other than cost, such as the physician-patient relationship and a patient’s education, may play an important role in the persistence of topical glaucoma medication.

This retrospective case-control study suggests that hydroxychloroquine retinopathy is more common than previously recognized, especially at high dosages and long duration of use.

This randomized clinical trial identifies higher spectacle independency with bilateral toric intraocular lens implantation but no significant changes in other outcomes.