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April 2014, Vol 132, No. 4, Pages 375-508

In This Issue of JAMA Ophthalmology

Highlights

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):375. doi:10.1001/jamaophthalmol.2013.5933
Viewpoint

Fuchs Endothelial Corneal Dystrophy: A Neurodegenerative Disorder?

Abstract Full Text
JAMA Ophthalmol. 2014;132(4):377-378. doi:10.1001/jamaophthalmol.2013.7993
Editorial

Safety and Complications of Ocriplasmin: Ocriplasmin, Ocriplasmin; Oh, How Safe Art Thou?

Abstract Full Text
JAMA Ophthalmol. 2014;132(4):379-380. doi:10.1001/jamaophthalmol.2014.278
Original Investigation

Journal Club

Vision Restoration Training for Glaucoma: A Randomized Clinical Trial

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JAMA Ophthalmol. 2014;132(4):381-389. doi:10.1001/jamaophthalmol.2013.7963

Sabel and Gudlin determine if behavioral activation of areas of residual visual using daily 1-hour vision restoration training for glaucoma for 3 months improves detection accuracy compared with placebo. Interventions were computer-based vision restoration training for glaucoma or visual discrimination placebo training in the intact visual field.

Clinical Trial

Effectiveness of Intraocular Pressure–Lowering Medication Determined by Washout

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):390-395. doi:10.1001/jamaophthalmol.2013.7677

Jampel et al assess the effectiveness of intraocular pressure (IOP)–lowering medications in patients with open-angle glaucoma.

Clinical Sciences

Artifacts in Spectral-Domain Optical Coherence Tomography Measurements in Glaucoma

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):396-402. doi:10.1001/jamaophthalmol.2013.7974

Asrani et al determine the frequency and distribution of SD-OCT imaging artifacts in patients being evaluated for glaucoma. A retrospective cross-sectional study design was used to examine SD-OCT images of 277 consecutive patients. Retinal nerve fiber layer and macular thickness scans were included. Examples of common artifacts are provided.

Clinical Sciences

Resident-Performed Selective Laser Trabeculoplasty in Patients With Open-Angle Glaucoma

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):403-408. doi:10.1001/jamaophthalmol.2013.7651

Greninger et al evaluate the effectiveness and complications of selective laser trabeculoplasty (SLT) performed by resident ophthalmologists and identify predictors for success.

Laboratory Sciences

Safety and Effects of the Vector for the Leber Hereditary Optic Neuropathy Gene Therapy Clinical Trial

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):409-420. doi:10.1001/jamaophthalmol.2013.7630

Koilkonda et al demonstrate the safety and effects of the gene therapy vector to be used in a proposed gene therapy clinical trial for Leber hereditary optic neuropathy (LHON).

Epidemiology

Association of Race/Ethnicity With Visual Outcomes Following Acute Optic Neuritis: An Analysis of the Optic Neuritis Treatment Trial

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):421-427. doi:10.1001/jamaophthalmol.2013.7995

Moss et al investigated the associations of age, sex, and race/ethnicity with visual outcomes following acute optic neuritis through application of longitudinal data analysis techniques to the Optic Neuritis Treatment Trial data set. Patients of black and white race/ethnicity who enrolled in the trial within 8 days of symptom onset were included.

Clinical Sciences

Trial End Points and Natural History in Patients With G11778A Leber Hereditary Optic Neuropathy : Preparation for Gene Therapy Clinical Trial

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):428-436. doi:10.1001/jamaophthalmol.2013.7971

Lam et al monitor the natural history of G11778A Leber hereditary optic neuropathy to determine the optimal end points to assess the safety and efficacy of a planned gene therapy trial.

Clinical Sciences

Spectral-Domain Optical Coherence Tomography Staging and Autofluorescence Imaging in Achromatopsia

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):437-445. doi:10.1001/jamaophthalmol.2013.7987

Greenberg et al categorize achromatopsia into clinically identifiable stages using spectral-domain optical coherence tomography and describe fundus autofluorescence imaging in this condition.

Epidemiology

Markers of Inflammation, Oxidative Stress, and Endothelial Dysfunction and the 20-Year Cumulative Incidence of Early Age-Related Macular Degeneration: The Beaver Dam Eye Study

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):446-455. doi:10.1001/jamaophthalmol.2013.7671

Klein and colleagues examined the relationships of markers of inflammation, oxidative stress, and endothelial dysfunction to the 20-year cumulative incidence of early age-related macular degeneration.

Clinical Sciences

The Effects of Technological Advances on Outcomes for Elderly Persons With Exudative Age-related Macular Degeneration

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):456-463. doi:10.1001/jamaophthalmol.2013.7647

Sloan and Hanrahan assess the effects of new therapies for treating exudative ARMD among newly diagnosed Medicare beneficiaries. The study used a combination of a regression discontinuity design and propensity score matching. Outcome measures were onset of decrease in vision, vision loss or blindness, depression, and admission to a long-term care facility.

Epidemiology

Serum Carboxymethyllysine, an Advanced Glycation End Product, and Age-Related Macular Degeneration: The Age, Gene/Environment Susceptibility–Reykjavik Study

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):464-470. doi:10.1001/jamaophthalmol.2013.7664

Semba et al investigate the relationship between serum carboxymethyllysine, a major circulating advanced glycation end product, and age-related macular degeneration (AMD) in older adults.

Eye Care Availability and Access Among Individuals With Diabetes, Diabetic Retinopathy, or Age-Related Macular Degeneration

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):471-477. doi:10.1001/jamaophthalmol.2013.7682

Gibson examines whether availability of ophthalmologists and optometrists is associated with access to eye care for individuals with diabetes, diabetic retinopathy, or age-related macular degeneration.

Epidemiology

Retinoblastoma Incidence Patterns in the US Surveillance, Epidemiology, and End Results Program

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):478-483. doi:10.1001/jamaophthalmol.2013.8001

Wong and coauthors examine updated US retinoblastoma incidence patterns by sex, age at diagnosis, laterality, race/ethnicity, and year of diagnosis.

Brief Report

Acute Panretinal Structural and Functional Abnormalities After Intravitreous Ocriplasmin Injection

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):484-486. doi:10.1001/jamaophthalmol.2013.8142

Fahim et al evaluated a woman with acute panretinal dysfunction after intravitreous ocriplasmin injection for a small macular hole with vitreomacular adhesion. B-waves were reduced more than A-waves were, suggesting postreceptoral dysfunction and decreased photoreceptor activity.

Vision Loss After Intravitreal Ocriplasmin: Correlation of Spectral-Domain Optical Coherence Tomography and Electroretinography

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):487-490. doi:10.1001/jamaophthalmol.2013.8258

Tibbetts and coauthors describe a woman with symptomatic vitreomacular traction who received intravitreal ocriplasmin and experienced darkening of vision.

Special Communication

“The El Greco Fallacy” Fallacy

Abstract Full Text
JAMA Ophthalmol. 2014;132(4):491-494. doi:10.1001/jamaophthalmol.2013.5684

Simunovic discusses the El Greco fallacy, which posits that the elongation evident in El Greco’s art reflects an underlying perceptual elongation of objects caused by astigmatism.

Surgical Technique

Midstromal Isolated Bowman Layer Graft for Reduction of Advanced Keratoconus: A Technique to Postpone Penetrating or Deep Anterior Lamellar Keratoplasty

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):495-501. doi:10.1001/jamaophthalmol.2013.5841

van Dijk et al describe a new surgical technique using a midstromal implant of a donor-isolated Bowman layer graft to reduce ectasia in eyes with advanced keratoconus.

JAMA Ophthalmology Clinical Challenge

Cotton-Wool Spots and Retinal Hemorrhages

Abstract Full Text
JAMA Ophthalmol. 2014;132(4):503-504. doi:10.1001/jamaophthalmol.2014.198
Research Letter

Disablement-Based Nomenclature for Vision and Function

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):505. doi:10.1001/jamaophthalmol.2014.154
Observation

Varicella-Zoster Virus Detection in Varicella-Associated Stromal Keratitis

Abstract Full Text
JAMA Ophthalmol. 2014;132(4):505-506. doi:10.1001/jamaophthalmol.2013.8254

Rapid Progression of Uveitis and Alopecia Syphilitica in AIDS

Abstract Full Text
JAMA Ophthalmol. 2014;132(4):506-508. doi:10.1001/jamaophthalmol.2014.7
JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
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JAMA Ophthalmol. 2014;132(4):376. doi:10.1001/jamaophthalmol.2013.5934
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