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August 2014, Vol 132, No. 8, Pages 913-1032

In This Issue of JAMA Ophthalmology

Highlights

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JAMA Ophthalmol. 2014;132(8):913. doi:10.1001/jamaophthalmol.2013.5953
Original Investigation

Sustained Visual Acuity Loss in the Comparison of Age-Related Macular Degeneration Treatments Trials

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JAMA Ophthalmol. 2014;132(8):915-921. doi:10.1001/jamaophthalmol.2014.1019

Ying and coauthors assess sustained visual acuity loss after 2 years of treatment with ranibizumab or bevacizumab for neovascular age-related macular degeneration.

Sex- and Age-Specific Prevalence and Incidence Rates of Sight-Threatening Diabetic Retinopathy in Taiwan

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JAMA Ophthalmol. 2014;132(8):922-928. doi:10.1001/jamaophthalmol.2014.859

Lin et al use a national health insurance database in Taiwan to determine contemporary estimates of the prevalence and incidence of sight-threatening diabetic retinopathy in patients with type 2 diabetes mellitus.

Clinical Sciences

Correlation Between Clinical Signs and Optical Coherence Tomography With Enhanced Depth Imaging Findings in Patients With Birdshot Chorioretinopathy

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JAMA Ophthalmol. 2014;132(8):929-935. doi:10.1001/jamaophthalmol.2014.877

Birnbaum et al determine the correlation between symptoms and signs of disease activity in birdshot chorioretinopathy (BCR) and specific findings on optical coherence tomography with enhanced depth imaging (OCT-EDI).

Combined Intravitreal Melphalan and Topotecan for Refractory or Recurrent Vitreous Seeding From Retinoblastoma

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JAMA Ophthalmol. 2014;132(8):936-941. doi:10.1001/jamaophthalmol.2014.414

Ghassemi et al describe the efficacy and complications of combined intravitreal chemotherapy, using melphalan and topotecan, for treatment of viable vitreous seeding from retinoblastoma.

Pingyangmycin as First-Line Treatment for Low-Flow Orbital or Periorbital Venous Malformations: Evaluation of 33 Consecutive Patients

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JAMA Ophthalmol. 2014;132(8):942-948. doi:10.1001/jamaophthalmol.2013.8229

Jia et al investigate the efficacy and safety of intralesional injection of pingyangmycin for treatment of low-flow orbital or periorbital venous malformations.

Lysyl Oxidase–Like 1 Gene in the Reversal of Promoter Risk Allele in Pseudoexfoliation Syndrome

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JAMA Ophthalmol. 2014;132(8):949-955. doi:10.1001/jamaophthalmol.2014.845

Dubey et al investigate the potential association of genetic variants across the LOXL1 gene in South Indian patients with pseudoexfoliation syndrome and glaucoma.

Single vs Multiple Intraocular Pressure Measurements in Glaucoma Surgical Trials

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JAMA Ophthalmol. 2014;132(8):956-962. doi:10.1001/jamaophthalmol.2014.867

Zhang et al determine whether a single IOP measurement might adequately approximate the mean of several measurements in glaucoma surgical trials.

Adjustable Nasal Transposition of Split Lateral Rectus Muscle for Third Nerve Palsy

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JAMA Ophthalmol. 2014;132(8):963-969. doi:10.1001/jamaophthalmol.2014.756

Shah and colleagues evaluate the oculomotor outcomes, anatomical changes, and complications associated with adjustable nasal transposition of the split lateral rectus muscle, a novel technique for managing strabismus associated with third nerve palsy.

Mutation in TMEM98 in a Large White Kindred With Autosomal Dominant Nanophthalmos Linked to 17p12-q12

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JAMA Ophthalmol. 2014;132(8):970-977. doi:10.1001/jamaophthalmol.2014.946

Awadalla et al perform a clinical and genetic investigation of a large white family with autosomal dominant nanophthalmos.

Two-Year Changes in Refractive Error and Related Biometric Factors in an Adult Chinese Population

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JAMA Ophthalmol. 2014;132(8):978-984. doi:10.1001/jamaophthalmol.2014.1011

He et al evaluate cohort effects and changes associated with aging in refractive errors among Chinese adults.

Alteration of Tear Mucin 5AC in Office Workers Using Visual Display Terminals: The Osaka Study

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JAMA Ophthalmol. 2014;132(8):985-992. doi:10.1001/jamaophthalmol.2014.1008

Uchino et al determine the relationship between mucin 5AC (MUC5AC) concentrations in the tears of visual display terminal users based on the diagnosis of dry eye disease and frequency of ocular symptoms.

Brief Report

Methicillin-Resistant Staphylococcus aureus Dacryoadenitis

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JAMA Ophthalmol. 2014;132(8):993-995. doi:10.1001/jamaophthalmol.2014.965

Liu et al describe 3 cases of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) acute dacryoadenitis.

Expansion of Ocular Phenotypic Features Associated With Mutations in ADAMTS18

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JAMA Ophthalmol. 2014;132(8):996-1001. doi:10.1001/jamaophthalmol.2014.940

Chandra et al describe the phenotypic characterization in newly reported patients with homozygous mutations in ADAMTS18 and report novel mutational data.

Nonpenetrance of the Most Frequent Autosomal Recessive Leber Congenital Amaurosis Mutation in NMNAT1

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JAMA Ophthalmol. 2014;132(8):1002-1004. doi:10.1001/jamaophthalmol.2014.983

Siemiatkowska and coauthors describe mutation of the NMNAT1 gene in a subset of patients with Leber congenital amaurosis and macular atrophy.

Bilateral Subfoveal Neurosensory Retinal Detachment Associated With MEK Inhibitor Use for Metastatic Cancer

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JAMA Ophthalmol. 2014;132(8):1005-1009. doi:10.1001/jamaophthalmol.2014.976

McCannel et al report bilateral subfoveal neurosensory retinal detachments in 3 patients with metastatic cancer undergoing systemic therapy with MEK inhibitors.

Surgical Technique

Use of Topical Ice for Local Anesthesia for Intravitreal Injections

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JAMA Ophthalmol. 2014;132(8):1010-1011. doi:10.1001/jamaophthalmol.2014.1397
JAMA Ophthalmology Clinical Challenge

Numbness of the Forehead

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JAMA Ophthalmol. 2014;132(8):1013-1014. doi:10.1001/jamaophthalmol.2014.1415

Shimmering Lights

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JAMA Ophthalmol. 2014;132(8):1015-1016. doi:10.1001/jamaophthalmol.2014.1444
Research Letter

Accelerometer-Assessed Physical Activity and Diabetic Retinopathy in the United States

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JAMA Ophthalmol. 2014;132(8):1017-1019. doi:10.1001/jamaophthalmol.2014.402

Squamous Cell Carcinoma With Clear-Cell Features of the Palpebral Conjunctiva

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JAMA Ophthalmol. 2014;132(8):1019-1021. doi:10.1001/jamaophthalmol.2014.971

Effect of Topical Rebamipide on Human Conjunctival Goblet Cells

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JAMA Ophthalmol. 2014;132(8):1021-1022. doi:10.1001/jamaophthalmol.2014.431

Adalimumab for Pediatric Sympathetic Ophthalmia

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JAMA Ophthalmol. 2014;132(8):1022-1024. doi:10.1001/jamaophthalmol.2014.426
Observation

Tethered Vitreous Seeds Following Intravitreal Melphalan for Retinoblastoma

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JAMA Ophthalmol. 2014;132(8):1024-1025. doi:10.1001/jamaophthalmol.2014.436

Sebaceous Carcinoma of the Eyelid and Muir-Torre Syndrome

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JAMA Ophthalmol. 2014;132(8):1025-1028. doi:10.1001/jamaophthalmol.2014.1026

Delayed-Onset Interface Fluid Syndrome After Laser-Assisted In Situ Keratomileusis Secondary to Descemet Stripping Automated Endothelial Keratoplasty

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JAMA Ophthalmol. 2014;132(8):1028-1029. doi:10.1001/jamaophthalmol.2014.960
Ophthalmic Images

Iris Flocculi

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JAMA Ophthalmol. 2014;132(8):935. doi:10.1001/jamaophthalmol.2013.7750

Infliximab Infusion Resulting in Rapid Resolution of Episcleritis

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JAMA Ophthalmol. 2014;132(8):941. doi:10.1001/jamaophthalmol.2013.7746

Mycobacterium chelonae Keratitis in a 3-Decade-Old Corneal Graft

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JAMA Ophthalmol. 2014;132(8):962. doi:10.1001/jamaophthalmol.2014.156

Preretinal and Posterior Vitreous Deposits in Gaucher Disease

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JAMA Ophthalmol. 2014;132(8):992. doi:10.1001/jamaophthalmol.2013.7817
Comment & Response

Follow-up on Anterior Chamber Angiostrongyliasis

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JAMA Ophthalmol. 2014;132(8):1029-1030. doi:10.1001/jamaophthalmol.2014.1799

Vulnerable Populations in the Underuse of the US Health Care System by Persons With Diabetes Mellitus and Diabetic Macular Edema

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JAMA Ophthalmol. 2014;132(8):1030. doi:10.1001/jamaophthalmol.2014.1759

Vulnerable Populations in the Underuse of the US Health Care System by Persons With Diabetes Mellitus and Diabetic Macular Edema—Reply

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JAMA Ophthalmol. 2014;132(8):1030-1031. doi:10.1001/jamaophthalmol.2014.2445

Making Sense of the Evidence From the Age-Related Eye Disease Study 2 Randomized Clinical Trial

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JAMA Ophthalmol. 2014;132(8):1031. doi:10.1001/jamaophthalmol.2014.2007

Making Sense of the Evidence From the Age-Related Eye Disease Study 2 Randomized Clinical Trial—Reply

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JAMA Ophthalmol. 2014;132(8):1031-1032. doi:10.1001/jamaophthalmol.2014.2009
JAMA Ophthalmology Masthead

JAMA Ophthalmology

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JAMA Ophthalmol. 2014;132(8):914. doi:10.1001/jamaophthalmol.2013.5954
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