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Issue

December 2015, Vol 133, No. 12, Pages 1373-1484

In This Issue of JAMA Ophthalmology

Highlights

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1373. doi:10.1001/jamaophthalmol.2014.3752
Viewpoint

Angiopoietin-like 4 as an Emerging Therapeutic Target for Diabetic Eye Disease

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1375-1376. doi:10.1001/jamaophthalmol.2015.3723

This Viewpoint discusses the role of angiopoietin-like 4 in the pathogenesis of diabetic eye disease.

Original Investigation

Relationships Between Measures of the Ability to Perform Vision-Related Activities, Vision-Related Quality of Life, and Clinical Findings in Patients With Glaucoma

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1377-1385. doi:10.1001/jamaophthalmol.2015.3426

This 4-year longitudinal observational study examines the relationships between clinical visual assessments and both a vision-related performance and 2 self-reported vision-related quality of life measurements.

Correlation of Severity of Fuchs Endothelial Corneal Dystrophy With Triplet Repeat Expansion in TCF4

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1386-1391. doi:10.1001/jamaophthalmol.2015.3430

This cross-sectional study examines the effect of the CTG18.1 triplet repeat expansion in TCF4 on the severity of Fuchs endothelial corneal dystrophy.

Interreader Variability of Computed Tomography for Orbital Floor Fracture

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1393-1397. doi:10.1001/jamaophthalmol.2015.3501

This case series assesses the interreader variability of computed tomography for orbital floor fracture measurements.

Population Prevalence of Need for Spectacles and Spectacle Ownership Among Urban Migrant Children in Eastern China

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1399-1406. doi:10.1001/jamaophthalmol.2015.3513

This cross-sectional study evaluates spectacle need and ownership among Chinese urban migrant children.

Role of Educational Exposure in the Association Between Myopia and Birth Order

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1408-1414. doi:10.1001/jamaophthalmol.2015.3556

This cross-sectional study examines whether myopia is associated with birth order in an earlier generation than studied previously.

Intakes of Lutein, Zeaxanthin, and Other Carotenoids and Age-Related Macular Degeneration During 2 Decades of Prospective Follow-up

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1415-1424. doi:10.1001/jamaophthalmol.2015.3590

This cohort study investigates the associations between intakes of carotenoids and age-related macular degeneration (AMD).

Qualifying to Use a Home Monitoring Device for Detection of Neovascular Age-Related Macular Degeneration

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1425-1430. doi:10.1001/jamaophthalmol.2015.3684

This study evaluates the utility of a qualification test to determine whether patients with high-risk age-related macular degeneration will be able to use a home monitoring device.

A 3-D “Super Surface” Combining Modern Intraocular Lens Formulas to Generate a “Super Formula” and Maximize Accuracy

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1431-1436. doi:10.1001/jamaophthalmol.2015.3832

This study describes the development of a 3-D graphical formula to calculate the most accurate power of an intraocular lens by incorporating the ideal segments from each of the existing formulas.

A Region-of-Interest Approach for Detecting Progression of Glaucomatous Damage With Optical Coherence Tomography

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1438-1444. doi:10.1001/jamaophthalmol.2015.3871

This study of a convenience sample of 16 patients with a history of optic disc hemorrhage compares measure of progressive changes in glaucomatous damage using an optical coherence tomography region-of-interest approach vs global retinal nerve fiber layer thickness profiles.

Antibiotic Resistance Among Ocular Pathogens in the United States: Five-Year Results From the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) Surveillance Study

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1445-1454. doi:10.1001/jamaophthalmol.2015.3888

This surveillance study of antibiotic resistance examines 5 years of ocular isolates collected from clinical centers across the United States.

Brief Report

Anterior Segment Seeding in Eyes With Retinoblastoma Failing to Respond to Intraophthalmic Artery Chemotherapy

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1455-1458. doi:10.1001/jamaophthalmol.2015.2861

This case series describes anterior segment seeding in enucleated eyes with retinoblastoma that had failed to respond to intraophthalmic artery chemotherapy.

Anterior Ocular Toxicity of Intravitreous Melphalan for Retinoblastoma

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1459-1463. doi:10.1001/jamaophthalmol.2015.3119

This case series describes the toxic effects of intravitreous injection of melphalan in 5 patients during treatment of retinoblastoma.

Reporting Weaknesses in Conference Abstracts of Diagnostic Accuracy Studies in Ophthalmology

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1464-1467. doi:10.1001/jamaophthalmol.2015.3577

This brief report discusses the deficiencies in abstracts presented at the 2010 Annual Meeting of the Association for Research in Vision and Ophthalmology.

Invited Commentary

Genetics of Fuchs Corneal Dystrophy Comes of Age: Sweet Repeats

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1392. doi:10.1001/jamaophthalmol.2015.3445

The Opportunity of Variability

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1397-1398. doi:10.1001/jamaophthalmol.2015.3816

Impaired Visual Acuity and Spectacle Ownership of Urban Migrant Children in Eastern China

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1406-1407. doi:10.1001/jamaophthalmol.2015.3664

State-of-the-Art of Intraocular Lens Power Formulas

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1436-1437. doi:10.1001/jamaophthalmol.2015.3844
JAMA Ophthalmology Clinical Challenge

Optic Nerve Atrophy and Hair Loss in a Young Man

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1469-1470. doi:10.1001/jamaophthalmol.2015.1957

A young man presents with color blindness, vision loss, and a recent history of confusion, short-term memory loss, vomiting, diarrhea, and hair loss. What would you do next?

Cotton-Wool Spots Associated With Mild Nonprogressive Visual Loss

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1471-1472. doi:10.1001/jamaophthalmol.2015.1967

A healthy white man in his late 70s was referred for evaluation of nerve fiber layer infarcts after experiencing nonprogressive diminished vision in his left eye for 6 weeks. Dilated fundus examination showed a nerve fiber layer infarct inferior to the optic nerve in the right eye, and in the left eye, there were several scattered nerve fiber layer infarcts in the peripapillary region. What would you do next?

Research Letter

Validation of Corneal Endothelial Specular Microscopy in Children Under General Anesthesia

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1474-1476. doi:10.1001/jamaophthalmol.2015.3695

This case series compares the use of corneal endothelial specular microscopy in children under anesthesia with that in children who are awake.

Observation

Invasive Squamous Cell Carcinoma With Clear Cell Change of the Eyelid Arising in a Seborrheic Keratosis

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1476-1477. doi:10.1001/jamaophthalmol.2015.3439

This case report describes an invasive squamous cell carcinoma arising in the eyelid skin in a seborrheic keratosis.

Optical Coherence Tomography Angiography of Acute Macular Neuroretinopathy and Paracentral Acute Middle Maculopathy

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1478-1480. doi:10.1001/jamaophthalmol.2015.4100

This case report describes acute macular neuroretinopathy/paracentral acute middle maculopathy in a pregnant woman.

Ophthalmic Images

Posterior Polar Annular Choroidal Dystrophy

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):e152148. doi:10.1001/jamaophthalmol.2015.2148

This case report describes a young boy with a history of a ruptured left globe and a lack of light perception in the left eye.

Peripheral Vascular Occlusion in Acute Retinal Necrosis

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):e152157. doi:10.1001/jamaophthalmol.2015.2157

This case report describes the ophthalmologic findings in a patient with a history of leukemia, photophobia, and decreased vision in the left eye.

Cobalamin C Deficiency–Associated Pigmentary Retinopathy

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):e152161. doi:10.1001/jamaophthalmol.2015.2161

This case report describes a girl with poor vision in both eyes and examination findings consistent with cobalamin C deficiency–associated retinopathy.

Extraocular Extension of a Benign Ciliary Body Nevus

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):e153137. doi:10.1001/jamaophthalmol.2015.3137

This case report describes a woman who presented with a well-circumscribed, pigmented, episcleral lesion and extrascleral extension in her right eye.

Comment & Response

Accuracy of Laboratory Assays in Ophthalmic Practice

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1480. doi:10.1001/jamaophthalmol.2015.3856

Accuracy of Laboratory Assays in Ophthalmic Practice—Reply

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1480-1481. doi:10.1001/jamaophthalmol.2015.3858

Progressively Increased Variation in Tear Osmolarity Mirrors Dry Eye Severity

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1481-1482. doi:10.1001/jamaophthalmol.2015.3854

Progressively Increased Variation in Tear Osmolarity Mirrors Dry Eye Severity—Reply

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1482. doi:10.1001/jamaophthalmol.2015.3860

Accuracy, Reliability, and Consistency in the Collection of Tear Film Osmolarity Data

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1482-1483. doi:10.1001/jamaophthalmol.2015.3863

Stereoscopic Surgical Recording Using GoPro Cameras: A Low-Cost Means for Capturing External Eye Surgery

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1483-1484. doi:10.1001/jamaophthalmol.2015.3865

Accuracy, Reliability, and Consistency in the Collection of Tear Film Osmolarity Data—Reply

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1483. doi:10.1001/jamaophthalmol.2015.3897

Stereoscopic Surgical Recording Using GoPro Cameras—Reply

Abstract Full Text
JAMA Ophthalmol. 2015;133(12):1484. doi:10.1001/jamaophthalmol.2015.3879
JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
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JAMA Ophthalmol. 2015;133(12):1374. doi:10.1001/jamaophthalmol.2014.3753
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