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April 2020 - January 1929

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Issue

July 2015, Vol 133, No. 7, Pages 739-857

In This Issue of JAMA Ophthalmology

Highlights

Abstract Full Text
free access
JAMA Ophthalmol. 2015;133(7):739. doi:10.1001/jamaophthalmol.2014.3727
Viewpoint

Eyes on Ebola Virus Disease

Abstract Full Text
JAMA Ophthalmol. 2015;133(7):743-744. doi:10.1001/jamaophthalmol.2015.0703

This Viewpoint reports on Ebola virus disease and the current Ebola epidemic, which has been deemed the largest in history.

The Uncertainty Regarding Antiretinal Antibodies

Abstract Full Text
JAMA Ophthalmol. 2015;133(7):744-745. doi:10.1001/jamaophthalmol.2015.0812

This Viewpoint discusses the importance of standardization in serum antiretinal antibody testing for diagnosing autoimmune retinopathy.

Original Investigation

Self-reported Calcium Supplementation and Age-Related Macular Degeneration

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):746-754. doi:10.1001/jamaophthalmol.2015.0514

This cross-sectional study found an association between supplementary calcium consumption and increased prevalence of age-related macular degeneration.

Clinical Trial

Additive Intraocular Pressure–Lowering Effects of the Rho Kinase Inhibitor Ripasudil (K-115) Combined With Timolol or Latanoprost: A Report of 2 Randomized Clinical Trials

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):755-761. doi:10.1001/jamaophthalmol.2015.0525

These multicenter, randomized comparison studies found additive IOP-lowering effects of ripasudil in combination with timolol and latanoprost.

Clinically Meaningful Rehabilitation Outcomes of Low Vision Patients Served by Outpatient Clinical Centers

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):762-769. doi:10.1001/jamaophthalmol.2015.0693

This prospective, observational study reports that 44% to 50% of patients presenting for outpatient low vision rehabilitation (LVR) show clinically meaning differences in overall visual ability after LVR and that the average effect sizes in overall visual ability are large, close to 1 SD.

Parallel Gene Expression Changes in Sarcoidosis Involving the Lacrimal Gland, Orbital Tissue, or Blood

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):770-777. doi:10.1001/jamaophthalmol.2015.0726

This observational study determines gene expression in sarcoidosis in the orbit or lacrimal gland compared with control tissue and blood samples.

Multinational Comparison of Prophylactic Antibiotic Use for Eyelid Surgery

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):778-784. doi:10.1001/jamaophthalmol.2015.0789

This survey study of members of ophthalmic plastic and reconstructive surgery societies shows that antibiotic prescribing practices for routine eyelid surgery vary widely throughout the world, although no standard of care requires postoperative prophylactic antibiotics after such procedures.

Phenotypic Characterization of Complement Factor H R1210C Rare Genetic Variant in Age-Related Macular Degeneration

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):785-791. doi:10.1001/jamaophthalmol.2015.0814

This retrospective observational study reports that typical phenotype of the complement factor H R1210C rare variant is associated with extensive drusen accumulation in the macula and throughout the fundus, as well as with a high risk for having advanced disease.

Long-term Risk of Melanoma-Related Mortality for Patients With Uveal Melanoma Treated With Proton Beam Therapy

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):792-796. doi:10.1001/jamaophthalmol.2015.0887

This analysis of a large series of patients with ocular melanoma treated conservatively with proton beam irradiation reports that the cumulative melanoma-related mortality rates continued to increase up to 23 years after treatment.

Journal Club

Association of Nonarteritic Ischemic Optic Neuropathy With Obstructive Sleep Apnea Syndrome: Consequences for Obstructive Sleep Apnea Screening and Treatment

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):797-804. doi:10.1001/jamaophthalmol.2015.0893

This cohort study recommends that polysomnography be considered in patients with nonarteritic anterior ischemic optic neuropathy.

Association of Cone-Rod Homeobox Transcription Factor Messenger RNA With Pediatric Metastatic Retinoblastoma

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):805-812. doi:10.1001/jamaophthalmol.2015.0900

This cohort study suggests that cone-rod homeobox messenger RNA is a specific marker for disseminated retinoblastoma in children.

Descemet Membrane Endothelial Keratoplasty for Graft Failure After Descemet Stripping Endothelial Keratoplasty: Clinical Results and Histopathologic Findings

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):813-819. doi:10.1001/jamaophthalmol.2015.0906

This prospective study recommends Descemet membrane endothelial keratoplasty for the treatment of patients with graft failure.

Association of Disorganization of Retinal Inner Layers With Vision After Resolution of Center-Involved Diabetic Macular Edema

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):820-825. doi:10.1001/jamaophthalmol.2015.0972

This cohort study suggests that the baseline presence and resolution pattern of disorganization of retinal inner layers may be associated with visual acuity after resolution of center-involved diabetic macular edema.

Occurrence of CYP1B1 Mutations in Juvenile Open-Angle Glaucoma With Advanced Visual Field Loss

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):826-833. doi:10.1001/jamaophthalmol.2015.0980

This cohort study of patients with advanced and nonadvanced juvenile open-angle glaucoma finds enrichment of CYP1B1 pathogenic variants and a more severe phenotype in those with advanced disease compared with unaffected controls.

Risk of Substantial Intraocular Bleeding With Novel Oral Anticoagulants: Systematic Review and Meta-analysis

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):834-839. doi:10.1001/jamaophthalmol.2015.0985

In this review study, randomized data suggest that no differences exist in the risk of substantial intraocular bleeding between non–vitamin K oral anticoagulants and other antithrombotic drugs.

Brief Report

Diagnostic Sensitivity of Indocyanine Green Angiography for Birdshot Chorioretinopathy

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):840-843. doi:10.1001/jamaophthalmol.2015.0822

This case series of 3 patients shows that those with retinal vasculitis and low-grade vitritis with or without macular edema may have birdshot chorioretinopathy evident on indocyanine green angiography before lesions are visible on clinical examination or fluorescein angiography.

JAMA Ophthalmology Clinical Challenge

Diplopia After a Sinus Infection

Abstract Full Text
JAMA Ophthalmol. 2015;133(7):845-846. doi:10.1001/jamaophthalmol.2015.0434

Bilateral Eyelid Nodules Impairing Eyelid Closure in 2 Siblings

Abstract Full Text
JAMA Ophthalmol. 2015;133(7):847-848. doi:10.1001/jamaophthalmol.2015.209
Observation

Chikungunya Virus Infection and Bilateral Stromal Keratouveitis

Abstract Full Text
JAMA Ophthalmol. 2015;133(7):849-850. doi:10.1001/jamaophthalmol.2015.0698

Enucleation as Endoscopic Sinus Surgery Complication

Abstract Full Text
JAMA Ophthalmol. 2015;133(7):850-852. doi:10.1001/jamaophthalmol.2015.0706

Peripheral Retinal Ischemia, Neovascularization, and Choroidal Infarction in Wyburn-Mason Syndrome

Abstract Full Text
JAMA Ophthalmol. 2015;133(7):852-854. doi:10.1001/jamaophthalmol.2015.0716

Severe Conjunctival Reaction Following Attempted Corneal Tattooing

Abstract Full Text
JAMA Ophthalmol. 2015;133(7):854-856. doi:10.1001/jamaophthalmol.2015.0934
Ophthalmic Images

Moniliform Blepharosis of Lipoid Proteinosis

Abstract Full Text
online only
JAMA Ophthalmol. 2015;133(7):e150688. doi:10.1001/jamaophthalmol.2015.0688

Synchysis Scintillans in a Child

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):e150793. doi:10.1001/jamaophthalmol.2015.0793

Silicone Oil Confined Within a Lamellar Macular Hole as Demonstrated by En Face Swept Source Optical Coherence Tomography

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):e15112. doi:10.1001/jamaophthalmol.2015.112

Invisible Retinoblastoma

Abstract Full Text
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JAMA Ophthalmol. 2015;133(7):e151123. doi:10.1001/jamaophthalmol.2015.1123
Comment & Response
JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
free access
JAMA Ophthalmol. 2015;133(7):741. doi:10.1001/jamaophthalmol.2014.3728
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