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August 2019 - January 1929

Decade

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Issue

January 2016, Vol 134, No. 1, Pages 7-115

In This Issue of JAMA Ophthalmology

Highlights

Abstract Full Text
free access
JAMA Ophthalmol. 2016;134(1):7. doi:10.1001/jamaophthalmol.2015.3208
Viewpoint

Ethics of Placebo Procedures in Ophthalmic Surgical Trials

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):11-12. doi:10.1001/jamaophthalmol.2015.4650

This Viewpoint assesses the ethical justification for the use of placebo procedures in ophthalmic surgery trials.

A Novel Treatment for Proliferative Diabetic Retinopathy: Anti–Vascular Endothelial Growth Factor Therapy

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):13-14. doi:10.1001/jamaophthalmol.2015.5079

This Viewpoint discusses the Diabetic Retinopathy Clinical Research Network randomized trial comparing ranibizumab vs panretinal photocoagulation for proliferative diabetic retinopathy in eyes with or without diabetic macular edema.

Original Investigation

Algorithm for the Measure of Vitreous Hyperreflective Foci in Optical Coherence Tomographic Scans of Patients With Diabetic Macular Edema

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):15-20. doi:10.1001/jamaophthalmol.2015.3949

This study of optical coherence tomographic scans evaluates an algorithm designed to measure vitreous hyperreflective foci in patients with diabetic retinopathy.

Systemic Safety of Prolonged Monthly Anti–Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema: A Systematic Review and Meta-analysis

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):21-29. doi:10.1001/jamaophthalmol.2015.4070

This systematic review and meta-analysis evaluates the systemic safety of intensive intravitreous anti–vascular endothelial growth factor therapy for diabetic macular edema in a population of high-risk patients.

Detection of Strabismus by Non–Health Care Professionals in an Ethnically Diverse Set of Images

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):30-36. doi:10.1001/jamaophthalmol.2015.4082

This study uses simulations of strabismus within photographs of white, black, and Asian models to determine the threshold angle at which lay observers detected the deviation.

Oral Fluoroquinolones and the Risk of Uveitis

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):38-43. doi:10.1001/jamaophthalmol.2015.4092

This cohort study compared oral fluoroquinolones with β-lactams to evaluate the risk of uveitis associated with the use of oral fluoroquinolones.

Effect of Regulatory Requirement for Patient-Specific Prescriptions for Off-Label Medications on the Use of Intravitreal Bevacizumab

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):45-48. doi:10.1001/jamaophthalmol.2015.4331

This review of billing data assesses changes in physicians’ prescribing of bevacizumab for age-related macular degeneration and diabetic macular edema after implementation of a regulatory requirement for patient-specific prescriptions for off-label medications.

Depression, Anxiety, and Regret Before and After Testing to Estimate Uveal Melanoma Prognosis

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):51-56. doi:10.1001/jamaophthalmol.2015.4343

This study assessed depression, anxiety, and decision regret in patients undergoing prognostication for uveal melanoma.

Evaluation of Frequency-Doubling Technology Perimetry as a Means of Screening for Glaucoma and Other Eye Diseases Using the National Health and Nutrition Examination Survey

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):57-62. doi:10.1001/jamaophthalmol.2015.4459

This reanalysis of cross-sectional data from NHANES reports that frequency-doubling technology lacks the sensitivity and specificity as a means of screening for glaucoma, the presence of macular disease, or decreased acuity in a population-based setting.

Variability of Ocular Deviation in Strabismus

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):63-69. doi:10.1001/jamaophthalmol.2015.4486

This comparative case study reports that in patients with strabismus, even without amblyopia, the deviated eye is more variable in position than the fixating eye.

Corneal Nerve Regeneration After Collagen Cross-Linking Treatment of Keratoconus: A 5-Year Longitudinal Study

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):70-78. doi:10.1001/jamaophthalmol.2015.4518

This study reports on whether collagen cross-linking treatment of keratoconus results in normalization of subbasal nerve density and architecture up to 5 years after treatment.

Journal Club

The Royal College of Ophthalmologists’ National Ophthalmology Database Study of Vitreoretinal Surgery: Report 6, Diabetic Vitrectomy

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):79-85. doi:10.1001/jamaophthalmol.2015.4587

This database study reviews a large number of vitrectomy procedures for patients with proliferative diabetic retinopathy and finds that the majority of eyes had a measurable improvement in vision, but the complication rate was appreciable.

Brief Report

Association Between Bortezomib Therapy and Eyelid Chalazia

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):88-90. doi:10.1001/jamaophthalmol.2015.3963

This observational study finds that spontaneous reports to the National Registry of Drug-Induced Ocular Side Effects and case reports in the literature suggest an association between bortezomib use and chalazia.

Association Between Graft Storage Time and Donor Age With Endothelial Cell Density and Graft Adherence After Descemet Membrane Endothelial Keratoplasty

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):91-94. doi:10.1001/jamaophthalmol.2015.4499

This case series reports an association between graft storage time and endothelial cell density decline after DMEK and possibly between donor age and graft detachment.

Invited Commentary

Detection of Socially Significant Strabismus in an Ethnically Diverse Model Set

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):36-37. doi:10.1001/jamaophthalmol.2015.4113

Controversy Surrounding the Proposed Ocular Adverse Events of Fluoroquinolones

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):43-44. doi:10.1001/jamaophthalmol.2015.4270

Patient and Physician Convenience and the Choice of Intravitreal Anti–Vascular Endothelial Growth Factor Medications

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):49-50. doi:10.1001/jamaophthalmol.2015.4115

Vitrectomy for Proliferative Diabetic Retinopathy: Does Anyone Know the Complication Rate?

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):86-87. doi:10.1001/jamaophthalmol.2015.4597
Special Communication

Comparison of Aflibercept, Bevacizumab, and Ranibizumab for Treatment of Diabetic Macular Edema: Extrapolation of Data to Clinical Practice

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):95-99. doi:10.1001/jamaophthalmol.2015.4110

This Special Communication discusses the American Society of Retina Specialists’ consensus review of a large comparative effectiveness trial evaluating 3 anti–vascular endothelial growth factor agents to treat diabetic macular edema.

JAMA Ophthalmology Clinical Challenge

Man With Blurry Vision and Eye Pain

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):101-102. doi:10.1001/jamaophthalmol.2015.2131

A man in his 40s from India presents with blurred vision, pain, posterior vitreous detachment, macular edema, and extensive peripheral retinal hemorrhage with obliterative vasculitis in the left eye. What would you do next?

Open-Angle Glaucoma and an Enlarged Superior Orbital Fissure Caused by Trauma

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):103-104. doi:10.1001/jamaophthalmol.2015.2465

A man in his 30s who had sustained a stab injury to his left orbit 15 years earlier was assessed for a proptotic left eye. The proptosis had a difference of 14 mm between eyes; the left eye had a palpable thrill, audible bruit, chemosis, dilated conjunctival blood vessels, and a swollen upper eyelid. What would you do next?

Asymptomatic Intraocular Mass

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):105-106. doi:10.1001/jamaophthalmol.2015.2522

An otherwise healthy Hispanic man in his 40s presents with a lesion in the temporal periphery of his left eye. What would you do next?

Research Letter

Proteomic Analysis of Macular Fluid Associated With Advanced Glaucomatous Excavation

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):108-110. doi:10.1001/jamaophthalmol.2015.4105

This case report describes the proteomic analysis of macular schisis fluid in a case of advanced glaucomatous cupping.

Observation

Periorbital Necrotizing Fasciitis Following Dexamethasone Intravitreal Implant Injection

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):110-111. doi:10.1001/jamaophthalmol.2015.4351

This case report describes periorbital necrotizing fasciitis after a patient received a dexamethasone intravitreal implant injection for diabetic macular edema.

Retinal Arterial Tortuosity in Moyamoya Disease

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):111-114. doi:10.1001/jamaophthalmol.2015.4645

This case report describes retinal arterial tortuosity associated with moyamoya disease.

Comment & Response

Incidence of Orbital Recurrence After Enucleation or Ophthalmic Artery Chemosurgery for Advanced Intraocular Retinoblastoma

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):114. doi:10.1001/jamaophthalmol.2015.4578

Incidence of Orbital Recurrence After Enucleation or Ophthalmic Artery Chemosurgery for Advanced Intraocular Retinoblastoma—Reply

Abstract Full Text
JAMA Ophthalmol. 2016;134(1):114-115. doi:10.1001/jamaophthalmol.2015.4581
Ophthalmic Images

Amelanotic Conjunctival Melanoma

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):e153568. doi:10.1001/jamaophthalmol.2015.3568

This Ophthalmic Image describes a case of amelanotic conjunctival melanoma in a man in his 60s.

Bilateral Iris Prolapse Secondary to Eye Rubbing Following Cataract Surgery

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):e153610. doi:10.1001/jamaophthalmol.2015.3610

This Ophthalmic Image describes a case of bilateral iris prolapse due to forceful rubbing following sequential cataract surgery.

An Innocuous Adverse Effect of Routine Fundus Fluorescein Angiography

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):e153624. doi:10.1001/jamaophthalmol.2015.3624

This Ophthalmic Image describes a case of yellow forearm venous staining after fundus fluorescein angiogram.

Bilateral Extraocular Muscle Metastases From a Gastrointestinal Carcinoid Tumor

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):e153651. doi:10.1001/jamaophthalmol.2015.3651

This Ophthalmic Image describes a case of bilateral extraocular muscle metastases from a gastrointestinal carcinoid tumor.

JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
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JAMA Ophthalmol. 2016;134(1):8-10. doi:10.1001/jamaophthalmol.2015.3209
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