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May 2019 - January 1929

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Issue

November 2017, Vol 135, No. 11, Pages 1135-1282

In This Issue of JAMA Ophthalmology

Highlights

Abstract Full Text
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JAMA Ophthalmol. 2017;135(11):1135. doi:10.1001/jamaophthalmol.2016.3762
Original Investigation

Surveillance Surveys for Reemergent Trachoma in Formerly Endemic Districts in Nepal From 2 to 10 Years After Mass Drug Administration Cessation

Abstract Full Text
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JAMA Ophthalmol. 2017;135(11):1141-1146. doi:10.1001/jamaophthalmol.2017.3062

This study of cross-sectional surveys administered in 2015 and 2016 determines the prevalence of trachoma among 4 districts in Nepal that each had surveillance intervals of 2, 4, 8, and 10 years after cessation of mass drug administration.

Genotype-Phenotype Associations of IL6 and PRG4 With Conjunctival Fibrosis After Glaucoma Surgery

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JAMA Ophthalmol. 2017;135(11):1147-1155. doi:10.1001/jamaophthalmol.2017.3407

This cross-sectional study compares the clinical phenotype of patients with conjunctival fibrosis after glaucoma surgery with candidate gene expression tissue biomarkers of fibrosis.

Gene Expression Profiling and Heterogeneity of Nonspecific Orbital Inflammation Affecting the Lacrimal Gland

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JAMA Ophthalmol. 2017;135(11):1156-1162. doi:10.1001/jamaophthalmol.2017.3458

This cohort study tests the a priori hypothesis that gene expression profiles would complement clinical and histopathologic evaluations in identifying well-characterized diseases and in subdividing nonspecific orbital inflammation into clinically relevant groups.

Ocular Histopathologic Features of Congenital Zika Syndrome

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JAMA Ophthalmol. 2017;135(11):1163-1169. doi:10.1001/jamaophthalmol.2017.3595

This case series evaluates the presence of Zika virus antigens and describes the associated ocular histopathologic features of 4 cases of congenital Zika syndrome.

Automated Grading of Age-Related Macular Degeneration From Color Fundus Images Using Deep Convolutional Neural Networks

Abstract Full Text
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JAMA Ophthalmol. 2017;135(11):1170-1176. doi:10.1001/jamaophthalmol.2017.3782

This study uses deep learning methods for the automated assessment of age-related macular degeneration from color fundus images.

Choroidal Features of Acute Macular Neuroretinopathy via Optical Coherence Tomography Angiography and Correlation With Serial Multimodal Imaging

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JAMA Ophthalmol. 2017;135(11):1177-1183. doi:10.1001/jamaophthalmol.2017.3790

This case series describes initial and serial multimodal imaging findings in acute macular neuroretinopathy with attention to choroidal vascular changes.

Association Between Fungal Contamination and Eye Bank–Prepared Endothelial Keratoplasty Tissue: Temperature-Dependent Risk Factors and Antifungal Supplementation of Optisol–Gentamicin and Streptomycin

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JAMA Ophthalmol. 2017;135(11):1184-1190. doi:10.1001/jamaophthalmol.2017.3797

This study determines whether eye bank–processed endothelial keratoplasty tissue is at higher risk of contamination than unprocessed tissue.

Long-term Outcomes After Proton Beam Irradiation in Patients With Large Choroidal Melanomas

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JAMA Ophthalmol. 2017;135(11):1191-1196. doi:10.1001/jamaophthalmol.2017.3805

This single-center cohort study analyzes 10-year outcomes of visual acuity, eye retention, development of neovascular glaucoma, tumor recurrence, and melanoma-related mortality in patients who underwent proton beam irradiation for large choroidal melanomas.

Choriocapillaris Imaging Using Multiple En Face Optical Coherence Tomography Angiography Image Averaging

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JAMA Ophthalmol. 2017;135(11):1197-1204. doi:10.1001/jamaophthalmol.2017.3904

This cross-sectional case series investigates multiple en face image averaging for optical coherence tomography angiography images of the choriocapillaris.

Efficacy and Safety of Ranibizumab With or Without Verteporfin Photodynamic Therapy for Polypoidal Choroidal Vasculopathy: A Randomized Clinical Trial

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JAMA Ophthalmol. 2017;135(11):1206-1213. doi:10.1001/jamaophthalmol.2017.4030

This randomized clinical trial compares the efficacy and safety of combination therapy of ranibizumab and verteporfin photodynamic therapy with ranibizumab monotherapy in polypoidal choroidal vasculopathy.

Association Between Opioid Prescribing Patterns and Abuse in Ophthalmology

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JAMA Ophthalmol. 2017;135(11):1216-1220. doi:10.1001/jamaophthalmol.2017.4055

This observational cohort study determines the opioid prescribing patterns among ophthalmologists and elucidates ophthalmologists’ role in the prescription opioid abuse epidemic.

Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma

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JAMA Ophthalmol. 2017;135(11):1221-1230. doi:10.1001/jamaophthalmol.2017.4097

This case series study investigates whether the aqueous humor of retinoblastoma eyes has sufficient tumor-derived DNA to perform genetic analysis of the tumor, including DNA copy number alterations.

Progression of Stargardt Disease as Determined by Fundus Autofluorescence in the Retrospective Progression of Stargardt Disease Study (ProgStar Report No. 9)

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JAMA Ophthalmol. 2017;135(11):1232-1241. doi:10.1001/jamaophthalmol.2017.4152

This multicenter cohort study describes the yearly progression rate of atrophic lesions as determined by fundus autofluorescence in the retrospective Progression of Stargardt Disease study.

Prevalence of Age-Related Macular Degeneration in Australia: The Australian National Eye Health Survey

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JAMA Ophthalmol. 2017;135(11):1242-1249. doi:10.1001/jamaophthalmol.2017.4182

This study examines the prevalence of age-related macular degeneration in Australia.

Time Requirements for Electronic Health Record Use in an Academic Ophthalmology Center

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JAMA Ophthalmol. 2017;135(11):1250-1257. doi:10.1001/jamaophthalmol.2017.4187

This single-center cohort study examines ophthalmologist time requirements for electronic health record use.

Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment: A Randomized Clinical Trial

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JAMA Ophthalmol. 2017;135(11):1259-1266. doi:10.1001/jamaophthalmol.2017.3398

This randomized clinical trial estimates the efficiency of dietary supplementation containing lutein, zeaxanthin, ω-3 polyunsaturated fatty acids, and vitamins to increase the density of macular pigment in first-generation offspring of parents with neovascular age-related macular degeneration.

Invited Commentary

Image Averaging, a Powerful Tool in Optical Coherence Tomography and Optical Coherence Tomography Angiography

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1204-1205. doi:10.1001/jamaophthalmol.2017.4015

Adopting the Results of Everest II Into Practice: A Clearer View From a Higher Level Study

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1214-1215. doi:10.1001/jamaophthalmol.2017.3118

Liquid Biopsy in Retinoblastoma

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1231. doi:10.1001/jamaophthalmol.2017.4094

How Much Time Should We Be Spending With Electronic Health Records?

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1257-1258. doi:10.1001/jamaophthalmol.2017.3517

The Role of Macular Pigment Density Measures in Future Clinical Studies of Age-Related Macular Degeneration

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1266-1267. doi:10.1001/jamaophthalmol.2017.0929
JAMA Ophthalmology Clinical Challenge

A Peaked Pupil

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1268-1269. doi:10.1001/jamaophthalmol.2017.2267

A 51-year-old woman presents with an 11-mm pigmented conjunctival lesion that was suspicious for melanoma with significant involvement of the caruncle, bulbar conjunctiva, and palpebral conjunctiva. What would you do next?

Acute-Onset Blurred Vision With Shallow Anterior Chamber and Suspected Choroidal Mass

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1270-1271. doi:10.1001/jamaophthalmol.2017.2299

A 67-year-old man with a history of elevated intraocular pressure presented to the ocular oncology service with acute-onset blurred vision and mild tenderness of his left eye. What would you do next?

Acute Bilateral Tonic Pupil in a Child

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1272-1273. doi:10.1001/jamaophthalmol.2017.2304

An 11-year-old child presents to the pediatric department with impaired vision after fever and vomiting. What would you do next?

A Man With Bilateral Peripheral Visual Field Loss

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1274-1275. doi:10.1001/jamaophthalmol.2017.2308

A 64-year-old man with a history of mild nuclear sclerosis presents to the Department of Ophthalmology with bilateral visual field loss. What would you do next?

Research Letter

Melanoma-Associated Retinopathy 28 Years After Diagnosis

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JAMA Ophthalmol. 2017;135(11):1276-1277. doi:10.1001/jamaophthalmol.2017.3500

This case report describes the 28-year follow-up of a man diagnosed with melanoma-associated retinopathy when he was in his 30s.

Observation

Ischemic Retinal Vascular Disease in an Infant With Hemophagocytic Lymphohistiocytosis

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1277-1279. doi:10.1001/jamaophthalmol.2017.3258

This case report is about the ophthalmic manifestations of hemophagocytic lymphohistiocytosis, a rare and often fatal disease commonly seen in infants.

Metallic Filament Embolization of the Retinal Artery

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1279-1281. doi:10.1001/jamaophthalmol.2017.3567

This case report describes a woman in her 40s with obscured vision in her right eye 3 years after undergoing endovascular coil embolization for a subarachnoid hemorrhage.

Comment & Response

Risk of Intraocular Bleeding and the New Anticoagulants: Not Such a Big Effect

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1281. doi:10.1001/jamaophthalmol.2017.4021

Risk of Intraocular Bleeding and the New Anticoagulants: Not Such a Big Effect—Reply

Abstract Full Text
JAMA Ophthalmol. 2017;135(11):1281-1282. doi:10.1001/jamaophthalmol.2017.4024
Correction

Error in Figure

Abstract Full Text
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JAMA Ophthalmol. 2017;135(11):1282. doi:10.1001/jamaophthalmol.2017.5304
Ophthalmic Images

Complete Vision Loss From Granulomatosis With Polyangiitis

Abstract Full Text
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JAMA Ophthalmol. 2017;135(11):e173851. doi:10.1001/jamaophthalmol.2017.3851

This case report describes a 34-year-old woman with complete vision loss from granulomatosis with polyangiitis.

Macular Horseshoe-Shaped Tear Following Cricket Injury

Abstract Full Text
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JAMA Ophthalmol. 2017;135(11):e173855. doi:10.1001/jamaophthalmol.2017.3855

This case report describes a teenage boy with a macular horseshoe-shaped tear.

Bleb-Associated Exogenous Nocardia Endophthalmitis

Abstract Full Text
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JAMA Ophthalmol. 2017;135(11):e174276. doi:10.1001/jamaophthalmol.2017.4276

A woman in her 60s with known human leukocyte antigen B27 positivity was referred for protracted intraocular inflammation and intractable pain five 5 months after trabeculectomy in the right eye.

En Face Optical Coherence Tomography of Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis

Abstract Full Text
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JAMA Ophthalmol. 2017;135(11):e174280. doi:10.1001/jamaophthalmol.2017.4280

A woman in her 60s presented with 2 months of blurred vision in the left eye, with visual acuity of 20/40. Examination of the left ocular fundus revealed spokelike foveal cysts.

JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
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JAMA Ophthalmol. 2017;135(11):1137. doi:10.1001/jamaophthalmol.2016.3763
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