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April 2019 - January 1929

Decade

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Issue

December 2017, Vol 135, No. 12, Pages 1289-1458

In This Issue of JAMA Ophthalmology

Highlights

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1289. doi:10.1001/jamaophthalmol.2016.3767
Viewpoint

Accelerating Innovation in Ophthalmic Digital Health: New Frontiers for Medical Devices

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1291-1292. doi:10.1001/jamaophthalmol.2017.4376

This Viewpoint discusses the opportunities and public health considerations of digital health technology.

Editorial

Death by Gun Violence—A Public Health Crisis

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1293-1294. doi:10.1001/jamaophthalmol.2017.5180
Original Investigation

Association of Socioeconomics With Prevalence of Visual Impairment and Blindness

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1295-1302. doi:10.1001/jamaophthalmol.2017.3449

This cross-sectional study explores correlations of the prevalence of visual impairment with socioeconomic factors at country levels and models and estimates a socioeconomic-adjusted disease burden based on these data.

Prevalence and Associations of Central-Peripheral Rivalry–Type Diplopia in Patients With Epiretinal Membrane

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1303-1309. doi:10.1001/jamaophthalmol.2017.4350

This cross-sectional study assesses the prevalence of central-peripheral rivalry–type diplopia in a group of patients with epiretinal membrane and describes the clinical associations of patients with epiretinal membrane and central-periphery rivalry–type diplopia vs patients with epiretinal membrane and no central-periphery rivalry–type diplopia.

Optical Coherence Tomography Angiography for Assessment of the 3-Dimensional Structures of Polypoidal Choroidal Vasculopathy

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1310-1316. doi:10.1001/jamaophthalmol.2017.4360

This cohort study assesses the use of 3-dimensional imaging by means of optical coherence tomography angiography to show polypoidal complexes in patients with polypoidal choroidal vasculopathy.

Clinical Features and Outcomes of Patients With Tubercular Uveitis Treated With Antitubercular Therapy in the Collaborative Ocular Tuberculosis Study (COTS)–1

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1318-1327. doi:10.1001/jamaophthalmol.2017.4485

This international cohort study examines the clinical features of tubercular uveitis and the associations with response to antitubercular therapy.

Quantitative Autofluorescence Intensities in Acute Zonal Occult Outer Retinopathy vs Healthy Eyes

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1330-1338. doi:10.1001/jamaophthalmol.2017.4499

This study expands the range of approaches available to assist in the identification of acute zonal occult outer retinopathy by multimodal imaging and analyzes the fundus lesions by quantifying short-wavelength fundus autofluorescence and spectral-domain optical coherence tomography.

Diplopia-Related Ambulatory and Emergency Department Visits in the United States, 2003-2012

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1339-1344. doi:10.1001/jamaophthalmol.2017.4508

This secondary analysis of cross-sectional, population-based survey data collected in the United States from 2003 through 2012 assesses the frequency, diagnostic practices, and patient and physician characteristics in diplopia presentations to emergency department and ambulatory settings.

Development of an 18-Item Measure of Symptom Burden in Patients With Glaucoma From the Collaborative Initial Glaucoma Treatment Study’s Symptom and Health Problem Checklist

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1345-1351. doi:10.1001/jamaophthalmol.2017.4574

This measure development study introduces a shortened glaucoma symptom measure based on the Collaborative Initial Glaucoma Treatment Study Symptom and Health Problem Checklist and evaluates its psychometric properties among patients with open-angle glaucoma.

Diagnostic Value of Serum-Soluble Interleukin 2 Receptor Levels vs Angiotensin-Converting Enzyme in Patients With Sarcoidosis-Associated Uveitis

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1352-1358. doi:10.1001/jamaophthalmol.2017.4771

This cross-sectional study compares the value of determining serum levels of soluble interleukin 2 receptor with that of angiotensin-converting enzyme for diagnosing sarcoidosis in patients with uveitis.

Primary vs Secondary Endoscopic Dacryocystorhinostomy for Acute Dacryocystitis With Lacrimal Sac Abscess Formation: A Randomized Clinical Trial

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1361-1366. doi:10.1001/jamaophthalmol.2017.4798

This randomized clinical trial compares the clinical outcomes of primary with secondary endoscopic dacryocystorhinostomy in the treatment of acute dacryocystitis with lacrimal sac abscess.

Clinicopathological Features of Ocular Adnexal Mantle-Cell Lymphoma in an International Multicenter Cohort

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1367-1374. doi:10.1001/jamaophthalmol.2017.4810

This international multicenter cohort study characterizes the clinical features of ocular adnexal mantel cell lymphoma in 55 patients who received treatment from 1980 through 2015 at any of 6 health care centers.

Accuracy of Next-Generation Sequencing for Molecular Diagnosis in Patients With Infantile Nystagmus Syndrome

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1376-1385. doi:10.1001/jamaophthalmol.2017.4859

This case series assesses the accuracy of genomic data from next-generation sequencing and phenotypic data to enhance the definitive diagnosis of infantile nystagmus syndrome.

Association Between Perceived Barriers to Diabetes Self-management and Diabetic Retinopathy in Asian Patients With Type 2 Diabetes

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1387-1393. doi:10.1001/jamaophthalmol.2017.4888

This cross-sectional clinic-based study examines the association between perceived barriers to diabetes self-management and the severity spectrum of diabetic retinopathy in Asian patients with type 2 diabetes.

Corneal Endothelial Cell Loss 3 Years After Successful Descemet Stripping Automated Endothelial Keratoplasty in the Cornea Preservation Time Study: A Randomized Clinical Trial

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1394-1400. doi:10.1001/jamaophthalmol.2017.4970

This randomized clinical trial evaluates the preservation time of the donor cornea after Descemet stripping automated endothelial keratoplasty.

Effect of Cornea Preservation Time on Success of Descemet Stripping Automated Endothelial Keratoplasty: A Randomized Clinical Trial

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1401-1409. doi:10.1001/jamaophthalmol.2017.4989

This randomized noninferiority clinical trial examines whether the 3-year rate of graft success using corneal donor tissue preserved 8 to 14 days is noninferior to that of donor tissue preserved 7 days or less.

Association Between the Severity of Diabetic Retinopathy and Falls in an Asian Population With Diabetes: The Singapore Epidemiology of Eye Diseases Study

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1410-1416. doi:10.1001/jamaophthalmol.2017.4983

This post hoc cross-sectional analysis investigates the associations of diabetes and diabetic retinopathy severity with the likelihood of falling in participants from the multiethnic (Malay, Chinese, and Indian individuals) population-based Singapore Epidemiology of Eye Disease study.

Generational Differences in the 5-Year Incidence of Age-Related Macular Degeneration

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1417-1423. doi:10.1001/jamaophthalmol.2017.5001

This cohort study determines whether the 5-year risk for age-related macular degeneration decreased by generation and identifies factors that contributed to improvement in risk among aging individuals born in the latter half of the 20th century.

Brief Report

Risk of Extraocular Extension in Eyes With Retinoblastoma Receiving Intravitreous Chemotherapy

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1426-1429. doi:10.1001/jamaophthalmol.2017.4600

This study evaluates the risk of extraocular extension in eyes with retinoblastoma that have received intravitreous chemotherapy injections.

Posterior Pole Vascular Changes Before Treatment of Retinopathy of Prematurity

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1430-1433. doi:10.1001/jamaophthalmol.2017.4608

This study of infants with retinopathy of prematurity evaluates the vascular characteristics present when treatment was determined to be needed and the time elapsed from the last normal examination result to the decision to treat.

Molecular Characteristics of Conjunctival Melanoma Using Whole-Exome Sequencing

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1434-1437. doi:10.1001/jamaophthalmol.2017.4837

This study of archival samples of 5 patients identifies the molecular characteristics of conjuctival melanoma using next-generation whole-exome sequencing.

Invited Commentary

The Role of Optical Coherence Tomography Angiography in Polypoidal Choroidal Vasculopathy

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1316-1317. doi:10.1001/jamaophthalmol.2017.4453

Uveitis—The Tortured Tale of the Tubercle

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1328-1329. doi:10.1001/jamaophthalmol.2017.3514

Sarcoid, Bayes, and the Challenges of Laboratory Testing for Uveitis

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1359-1360. doi:10.1001/jamaophthalmol.2017.4789

Mantle-Cell Lymphoma—Taming the Tiger

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1374-1375. doi:10.1001/jamaophthalmol.2017.4290

Progress in Diagnostic Genetic Testing for Inherited Eye Disease

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1385-1386. doi:10.1001/jamaophthalmol.2017.4957

Age-Related Maculopathy—Degeneration by Generation

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1424-1425. doi:10.1001/jamaophthalmol.2017.5052
Surgical Technique

Use of Intraoperative Optical Coherence Tomography for Tube Positioning in Glaucoma Surgery

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1438-1439. doi:10.1001/jamaophthalmol.2017.4431

This test of concept study assesses the use of intraoperative optical coherence tomography to implant a glaucoma drainage device in cadaveric eyes.

JAMA Ophthalmology Clinical Challenge

Profound Vision Loss After a Traumatic Work Injury

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1440-1441. doi:10.1001/jamaophthalmol.2017.2326

A 43-year-old construction worker experienced bilateral lower extremity crush injuries after a large heavy object fell onto his thighs, amputating his right leg. He also had a left leg degloving injury, distal femur fracture, and posterior knee dislocation with bleeding through the open fractures and wounds. What would you do next?

Blepharitis With Facial Numbness and Ocular Pain

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1442-1443. doi:10.1001/jamaophthalmol.2017.2492

A man in his 60s presents with a 3-week history of unilateral facial numbness and severe ocular discomfort that did not resolve with antibiotic treatment. What would you do next?

Evaluation and Management of Unilateral Congenital Ptosis in a Healthy Child

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1444-1445. doi:10.1001/jamaophthalmol.2017.2593

A 5-year-old girl was referred for evaluation of blepharoptosis of the left eye. There was notable asymmetry in her eyelid measurements and elevation of her left upper eyelid with lateral jaw thrust. What would you do next?

Progressive Restrictive Strabismus in an Adult Woman

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1446-1447. doi:10.1001/jamaophthalmol.2017.2703

A woman in her 60s presents to the ophthalmology clinic with several months of binocular diplopia with blurred vision and upper eyelid droop of the left eye. What would you do next?

Research Letter

Evolution of Practice Patterns for the Treatment of Fungal Keratitis

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1448-1449. doi:10.1001/jamaophthalmol.2017.4763

This study examines changes in practice patterns for fungal keratitis.

Vision Loss Associated With the Opioid Epidemic

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1449-1451. doi:10.1001/jamaophthalmol.2017.4868

This medical record review study compares the clinical characteristics of endogenous endophthalmitis in patients with and without injection drug use.

Observation

A Case of Unexpected Adult-Onset Neurologic Decline in CLN3-Associated Retinal Degeneration

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1451-1453. doi:10.1001/jamaophthalmol.2017.4353

This case report describes a young man with a mutation in CLN3 who developed progressive retinal degeneration and neurologic dysfunction.

Intracameral Topotecan Hydrochloride for Anterior Chamber Seeding of Retinoblastoma

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1453-1454. doi:10.1001/jamaophthalmol.2017.4603

This case report describes the regression of anterior chamber tumor seeding using an intracameral injection of topotecan in the better-seeing eye of a child with bilateral retinoblastoma.

Combination Ipilimumab and Nivolumab for Metastatic Melanoma Associated With Ciliochoroidal Effusion and Exudative Retinal Detachment

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1455-1457. doi:10.1001/jamaophthalmol.2017.4872

This case report describes an African American man in his late 60s undergoing treatment of metastatic melanoma with adjuvant combination ipilimumab and nivolumab who develops bilateral choroidal effusions and exudative retinal detachments.

Comment & Response

Association of Endogenous Endophthalmitis With Intravenous Drug Use: An Emerging Public Health Challenge

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1457. doi:10.1001/jamaophthalmol.2017.4342

Endogenous Endophthalmitis Associated With Intravenous Drug Use—Reply

Abstract Full Text
JAMA Ophthalmol. 2017;135(12):1457-1458. doi:10.1001/jamaophthalmol.2017.4357
Ophthalmic Images

Optical Coherence Tomography Transecting an Omega Retinal Venous Loop en Face in a Patient With Diabetic Retinopathy

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):e174384. doi:10.1001/jamaophthalmol.2017.4384

This case report describes a woman in her mid-40s with bilateral proliferative diabetic retinopathy and omega retinal venous loop en face.

Ultra-Wide-Field Imaging of Spontaneously Dislocated Aphakic Soemmering Ring

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):e174767. doi:10.1001/jamaophthalmol.2017.4767

This case report describes a Korean woman in her late 80s who complained of a recent-onset visual shadow in the left eye, which appeared only in the supine position

Substantial Visual Field Loss Associated With Giant Optic Disc Drusen

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):e174778. doi:10.1001/jamaophthalmol.2017.4778

This care report describes a woman in her early 60s with giant optic disc drusen that caused substantial bilateral visual field loss.

Arcuate Retinal Nerve Fiber Layer Defect After Laser Photocoagulation for Diabetic Macular Edema

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):e174877. doi:10.1001/jamaophthalmol.2017.4877

This case report describes an individual aged mid-50s with diabetes and aneurysmal dilation with associated retinal edema and congenital vessel tortuosity.

JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
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JAMA Ophthalmol. 2017;135(12):1290. doi:10.1001/jamaophthalmol.2016.3768
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