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August 2019 - January 1929

Decade

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Issue

August 2018, Vol 136, No. 8, Pages 847-959

In This Issue of JAMA Ophthalmology

Highlights

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):847. doi:10.1001/jamaophthalmol.2017.3738
Original Investigation

Effect of Oral Valproic Acid vs Placebo for Vision Loss in Patients With Autosomal Dominant Retinitis Pigmentosa: A Randomized Phase 2 Multicenter Placebo-Controlled Clinical Trial

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):849-856. doi:10.1001/jamaophthalmol.2018.1171

This randomized clinical trial evaluates the potential efficacy and assesses the safety of orally administered valproic acid in the treatment of autosomal dominant retinitis pigmentosa.

Differential Survival of Penetrating and Lamellar Transplants in Management of Failed Corneal Grafts

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):859-865. doi:10.1001/jamaophthalmol.2018.1515

This national UK transplant registry study examines the corneal transplant replacement survival rates for the 3 main indications and types of regraft surgery.

Optical Coherence Tomography Angiography Compared With Optical Coherence Tomography Macular Measurements for Detection of Glaucoma

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):866-874. doi:10.1001/jamaophthalmol.2018.1627

This cross-sectional study compares the use of optical coherence tomography angiography with optical coherence tomography in the diagnosis and evaluation of inner macular thickness and inner macular vessel density in patients with glaucoma.

Association of Genetic Variants With Response to Anti–Vascular Endothelial Growth Factor Therapy in Age-Related Macular Degeneration

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):875-884. doi:10.1001/jamaophthalmol.2018.2019

This multicenter genome-wide association study identifies genetic factors associated with variability in the response to anti–vascular endothelial growth factor therapy for patients with neovascular age-related macular degeneration.

Association of the Gutta-Induced Microenvironment With Corneal Endothelial Cell Behavior and Demise in Fuchs Endothelial Corneal Dystrophy

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):886-892. doi:10.1001/jamaophthalmol.2018.2031

This study investigates the role of guttae in the pathogenesis of Fuchs endothelial corneal dystrophy by examining their association with corneal endothelial cell function.

Trends in US Emergency Department Visits for Pediatric Acute Ocular Injury

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):895-903. doi:10.1001/jamaophthalmol.2018.2062

This study characterizes pediatric acute ocular injury in the United States using data from a stratified, national sample of emergency department visits.

Incidence of Fellow Eye Involvement in Patients With Unilateral Exudative Age-Related Macular Degeneration

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):905-911. doi:10.1001/jamaophthalmol.2018.2154

This prospective observational study investigates the incidence of fellow eye involvement in patients with unilateral typical age-related macular degeneration or polypoidal choroidal vasculopathy.

Association of Pediatric Atopic Dermatitis and Cataract Development and Surgery

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):912-918. doi:10.1001/jamaophthalmol.2018.2166

This longitudinal study investigates the association of atopic dermatitis with subsequent cataract development and cataract surgery in a Korean pediatric population.

Visual Acuity Change Over 24 Months and Its Association With Foveal Phenotype and Genotype in Individuals With Stargardt Disease: ProgStar Study Report No. 10

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):920-928. doi:10.1001/jamaophthalmol.2018.2198

This cohort study analyzes the association of best-corrected visual acuity loss with foveal phenotype and genotype in patients with Stargardt disease.

Automated Quantification of Nonperfusion Areas in 3 Vascular Plexuses With Optical Coherence Tomography Angiography in Eyes of Patients With Diabetes

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):929-936. doi:10.1001/jamaophthalmol.2018.2257

This cross-sectional study quantifies capillary nonperfusion in 3 vascular plexuses in the macula of eyes of patients with diabetes and various retinopathy severity using projection-resolved optical coherence tomography angiography (OCTA).

Brief Report

Multiple-Choice Answer Form Completion Time in Children With Amblyopia and Strabismus

Abstract Full Text
JAMA Ophthalmol. 2018;136(8):938-941. doi:10.1001/jamaophthalmol.2018.2295

This cross-sectional study assesses an academic-related fine motor outcome—multiple-choice answer form completion time—in children with amblyopia and strabismus.

Invited Commentary

Methodological Insights for Randomized Clinical Trials of Retinitis Pigmentosa: Lessons Learned From a Trial of Valproic Acid

Abstract Full Text
JAMA Ophthalmol. 2018;136(8):857-858. doi:10.1001/jamaophthalmol.2018.1167

Understanding Variation in Response to Anti–Vascular Endothelial Growth Factor Therapy for Neovascular Age-Related Macular Degeneration

Abstract Full Text
JAMA Ophthalmol. 2018;136(8):884-885. doi:10.1001/jamaophthalmol.2018.0032

The Ongoing Puzzle of the Biological Behavior of Cornea Guttae

Abstract Full Text
JAMA Ophthalmol. 2018;136(8):893-894. doi:10.1001/jamaophthalmol.2018.1475

Uncovering Reasons Why Acute Ocular Injuries in Children May Be Declining

Abstract Full Text
JAMA Ophthalmol. 2018;136(8):904. doi:10.1001/jamaophthalmol.2018.2059

Assessing Whether the Cataracts Associated With Atopic Dermatitis Are Associated With Steroids or Inflammatory Factors

Abstract Full Text
JAMA Ophthalmol. 2018;136(8):918-919. doi:10.1001/jamaophthalmol.2018.2153

Optical Coherence Tomography Angiography to Evaluate Ischemia in Diabetic Eyes

Abstract Full Text
JAMA Ophthalmol. 2018;136(8):936-937. doi:10.1001/jamaophthalmol.2018.2256

Visuomotor Consequences of Abnormal Binocular Vision

Abstract Full Text
JAMA Ophthalmol. 2018;136(8):942-943. doi:10.1001/jamaophthalmol.2018.2289
JAMA Ophthalmology Clinical Challenge

Paraproteinemic Maculopathy in a 63-Year-Old Man

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):944-945. doi:10.1001/jamaophthalmol.2017.6285

A 63-year-old man with type 2 diabetes for 10 years was seen with decreased vision in both eyes. He was diagnosed as having nonproliferative diabetic retinopathy with macular edema in both eyes and received 3 intravitreal bevacizumab injections at 4 weekly intervals and 2 intravitreal triamcinalone acetonide injections in both eyes, with minimal resolution of edema. What would you do next?

Photophobia in an Immunocompromised Patient

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2018;136(8):946-947. doi:10.1001/jamaophthalmol.2017.6711

A woman in her early 50s with a history of cystic fibrosis, cytomegalovirus viremia, and chronic kidney disease who has been treated with cidofovir presents with headaches, bilateral photophobia, and blurry vision. What would you do next?

Subacute Vision Loss in a Young Pregnant Patient With Proliferative Diabetic Retinopathy

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):948-949. doi:10.1001/jamaophthalmol.2017.6760

A young pregnant woman with proliferative diabetic retinopathy presents with subacute bilateral vision loss. Examination reveals mild optic nerve head edema and macular edema. What would you do next?

Severe Progressive Vision Loss in a Teenager

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):950-951. doi:10.1001/jamaophthalmol.2017.6792

A 14-year-old girl was seen with progressive vision loss in both eyes. Optic nerve atrophy was noted, with no optociliary collaterals. Imaging of the retinal nerve fiber layer showed thinning in both eyes. What would you do next?

New Ophthalmoplegia and Recurrent Ptosis After Ptosis Repair Surgery

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2018;136(8):952-953. doi:10.1001/jamaophthalmol.2017.6810

A man in his 60s presents to your neuro-ophthalmology clinic with worsening ptosis after ptosis repair surgery. The affected eye demonstrates total ophthalmoplegia and enophthalmos. What would you do next?

Bilateral Retinal Detachments Presenting With Acute Angle Closure

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2018;136(8):954-955. doi:10.1001/jamaophthalmol.2017.6805

A woman presents with bilateral acute-angle closure and retinal detachments. What would you do?

Observation

Association of Macular and Peripheral Retinal Macro-Pseudocysts With Chronic Retinal Detachment

Abstract Full Text
JAMA Ophthalmol. 2018;136(8):956-958. doi:10.1001/jamaophthalmol.2018.2189

This case report describes a patient with chronic retinal detachment with large macular and peripheral retinal pseudocysts and discusses the histologic features of such retinal macro-pseudocysts and their implications.

Comment & Response

Generational Differences in Lifetime Exposure to Lead and the Decreasing Incidence of Age-Related Macular Degeneration

Abstract Full Text
JAMA Ophthalmol. 2018;136(8):958. doi:10.1001/jamaophthalmol.2018.2163

Generational Differences in Lifetime Exposure to Lead and the Decreasing Incidence of Age-Related Macular Degeneration—Reply

Abstract Full Text
JAMA Ophthalmol. 2018;136(8):958-959. doi:10.1001/jamaophthalmol.2018.2175
Correction

Content Omitted From Abstract

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):959. doi:10.1001/jamaophthalmol.2018.2865

Error in Key Points

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):959. doi:10.1001/jamaophthalmol.2018.2944
Ophthalmic Images

Swept-Source Optical Coherence Tomography Angiography of Microaneurysms in Myopic Retinoschisis

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):e181637. doi:10.1001/jamaophthalmol.2018.1637

This case report describes physical capillary disruption during inner retinal schisis enlargement in a woman in her 30s.

Punctate Retinal Pigment Epitheliopathy and Choroidopathy After Radiotherapy With Chemotherapy

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):e181754. doi:10.1001/jamaophthalmol.2018.1754

A woman in her mid-50s with squamous cell carcinoma in the right maxillary sinus developed widespread punctate pigment abnormalities consistent with radiation-related retinal pigment epitheliopathy after external beam radiation therapy.

Visualization of Capillary Dropout Emanating From an Optic Disc Pit Using Optical Coherence Tomography Angiography

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):e182327. doi:10.1001/jamaophthalmol.2018.2327

This case study describes a 9-year-old child with a radial spoke of capillary dropout emanating from the optic disc pit of the left eye.

Extensive Intraocular Osseous Metaplasia With Bone Marrow Formation

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):e182377. doi:10.1001/jamaophthalmol.2018.2377

This case study describes a 50-year-old man with intraocular bone formation 4 decades after ocular trauma.

JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
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JAMA Ophthalmol. 2018;136(8):848. doi:10.1001/jamaophthalmol.2017.3739
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