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September 2018, Vol 136, No. 9, Pages 965-1078

In This Issue of JAMA Ophthalmology

Highlights

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):965. doi:10.1001/jamaophthalmol.2017.3743
Viewpoint

Gene Editing as a Potential Therapeutic Solution for Fuchs Endothelial Corneal Dystrophy: The Future Is Clearer

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):969-970. doi:10.1001/jamaophthalmol.2018.2324

This Viewpoint explains the possibility of clustered regularly interspaced short palindromic repeats (CRISPR) gene editing becoming a means of treating Fuchs endothelial corneal dystrophy.

Original Investigation

Corneal Morphologic Characteristics in Patients With Down Syndrome

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):971-978. doi:10.1001/jamaophthalmol.2018.2373

This case-control study characterizes the irregular morphological features of the cornea in patients with Down syndrome and compares them with a control group using corneal topography.

Survival Rates in Patients After Treatment for Metastasis From Uveal Melanoma

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):981-986. doi:10.1001/jamaophthalmol.2018.2466

This study compares survival rates in patients who were treated for uveal melanoma.

Longitudinal Associations Between Visual Impairment and Cognitive Functioning: The Salisbury Eye Evaluation Study

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):989-995. doi:10.1001/jamaophthalmol.2018.2493

This longitudinal study evaluates the associations of visual impairment and cognitive function over time in a population-based study of older US adults.

Association of Cataract Surgery With Traffic Crashes

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):998-1007. doi:10.1001/jamaophthalmol.2018.2510

This population-based study assesses whether cataract surgery is associated with a reduction in serious traffic crashes where the patient was the driver.

Association Between the Cilioretinal Artery and Choroidal Neovascularization in Age-Related Macular Degeneration: A Secondary Analysis From the Age-Related Eye Disease Study

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):1008-1015. doi:10.1001/jamaophthalmol.2018.2650

This study examines whether the presence and location of a cilioretinal artery may be associated with the risk of choroidal neovascularization or central geographic atrophy and late age-related macular degeneration in adult participants of the Age-Related Eye Disease Study.

Incidence of and Factors Associated With Myopia and High Myopia in Chinese Children, Based on Refraction Without Cycloplegia

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):1017-1024. doi:10.1001/jamaophthalmol.2018.2658

This cohort study assesses the incidence of myopia and high myopia in Chinese children in primary and junior high schools, based on refraction without cycloplegia.

Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):1025-1031. doi:10.1001/jamaophthalmol.2018.2664

This case-control study develops and evaluates a set of diagnostic criteria for Vogt-Koyanagi-Harada disease, an immune-mediated disorder affecting both eyes, using data from Chinese patients.

Development of Modified Screening Criteria for Retinopathy of Prematurity: Primary Results From the Postnatal Growth and Retinopathy of Prematurity Study

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):1034-1040. doi:10.1001/jamaophthalmol.2018.2753

This cohort study aims to develop evidence-based retinopathy of prematurity screening criteria using data on birth weight, gestational age, and weight gain from a cohort of at-risk infants in North America.

Association of Change in Iris Vessel Density in Optical Coherence Tomography Angiography With Anterior Segment Ischemia After Strabismus Surgery

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):1041-1045. doi:10.1001/jamaophthalmol.2018.2766

This case series study analyzes the use of iris optic coherence tomography angiography (OCT-A) for patients undergoing strabismus surgery at risk for anterior segment ischemia.

Brief Report

Self-reported Eyeglass Use by US Medicare Beneficiaries Aged 65 Years or Older

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):1047-1050. doi:10.1001/jamaophthalmol.2018.2524

This cross-sectional study examines data from the US National Health and Aging Trends Study to estimate the prevalence of corrective lenses use among Medicare beneficiaries who are 65 years or older.

Invited Commentary

Topography and Tomography Findings in Patients With Down Syndrome

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):979-980. doi:10.1001/jamaophthalmol.2018.2374

Continued Poor Survival in Metastatic Uveal Melanoma: Implications for Molecular Prognostication, Surveillance Imaging, Adjuvant Therapy, and Clinical Trials

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):986-988. doi:10.1001/jamaophthalmol.2018.1813

Treating the Eyes to Help the Brain: The Association Between Visual and Cognitive Function

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):996-997. doi:10.1001/jamaophthalmol.2018.2491

The Cilioretinal Artery—A Friend to Age-Related Macular Degeneration?

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):1015-1016. doi:10.1001/jamaophthalmol.2018.2644

Improving the Diagnostic Criteria for Vogt-Koyanagi-Harada Disease

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):1032-1033. doi:10.1001/jamaophthalmol.2018.2657

Improving Access—but Not Outcomes—With Iris Optical Coherence Tomography Angiography

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):1045-1046. doi:10.1001/jamaophthalmol.2018.2748
Review

Appraising the Quality of Systematic Reviews for Age-Related Macular Degeneration Interventions: A Systematic Review

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):1051-1061. doi:10.1001/jamaophthalmol.2018.2620

This systematic review investigates the quality of 71 studies and notes that many age-related macular degeneration intervention reviews have major methodological limitations, and quality may not be improving over time.

JAMA Ophthalmology Clinical Challenge

Posterior Embryotoxon, Corectopia, and Cerebellar Dysgenesis

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):1062-1063. doi:10.1001/jamaophthalmol.2018.0101

An adolescent boy presents with posterior embryotoxon, corectopia, and cerebellar dysgenesis. What would you do next?

A White Lesion in the Retina

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):1064-1065. doi:10.1001/jamaophthalmol.2017.6819

A 16-year-old girl with an unremarkable medical and family history presented with blurry vision; results of posterior segment examination of the right eye revealed a slightly elevated, white, multicystic lesion approximately 3 disc diameters inferior to the optic nerve. What would you do next?

A Young Woman With Acute Visual Loss

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):1066-1067. doi:10.1001/jamaophthalmol.2018.0063

A young woman presented with sudden-onset visual loss in 1 eye without eye pain or visual phenomena, and 2 retinal lesions were identified. What would you do next?

Abnormal Ophthalmic Examination Results and Elevated Intracranial Pressure

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):1068-1069. doi:10.1001/jamaophthalmol.2018.0085

A man developed bilateral elevation of the optic nerve head with blurring of the disc margins and elevated intracranial pressure. What would you do?

A Middle-aged Woman With Vision Loss and Cecocentral Scotoma

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):1070-1071. doi:10.1001/jamaophthalmol.2018.0077

A woman in her early 50s presented with a 3-month history of decreased vision, cecocentral visual field defect in the right eye, and mildly hyperemic optic nerves with a few telangiectatic vessels on the left and trace temporal pallor on the right. What would you do next?

Bilateral Visual Field Loss in an Adolescent Girl With Migraine Headaches

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):1072-1073. doi:10.1001/jamaophthalmol.2017.6815

An adolescent girl with a history of migraine headaches reports worsening blurry vision on the right side of 2 weeks’ duration, and automated perimetry demonstrates a right-sided homonymous hemianopia. What would you do next?

Research Letter

Association of Space Flight With Problems of the Brain and Eyes

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):1075-1076. doi:10.1001/jamaophthalmol.2018.2635

This study explores the association of cerebrospinal fluid pressure and brain upward shift with space flight–associated neuroocular syndrome in postflight astronauts.

Observation

Choroideremia in a Woman With Turner Syndrome

Abstract Full Text
JAMA Ophthalmol. 2018;136(9):1076-1078. doi:10.1001/jamaophthalmol.2018.2630

This case report describes a 67-year-old woman with a fully expressed form of choroideremia due to coexistent Turner syndrome.

Ophthalmic Images

Bilateral Iris Metastasis From Pulmonary Adenocarcinoma

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):e182381. doi:10.1001/jamaophthalmol.2018.2381

This case report describes a man in his 60s who presented with a 1-month history of blurred vision without pain.

Treatment of Foveal Neovascularization in a Patient With Type 1 Diabetes

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):e182584. doi:10.1001/jamaophthalmol.2018.2584

This case report describes panretinal photocoagulation and intravitreal bevacizumab treatment in a patient with foveal retinal neovascularization.

Mizuo-Nakamura Phenomenon in a Middle-aged Woman

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):e182640. doi:10.1001/jamaophthalmol.2018.2640

This case report describes a woman in her 40s who had a golden-yellow reflex in both eyes that disappeared after 3 hours of dark adaptation.

A Surprise Guest—Insect Larva Under An Uncomplicated Laser-Assisted In Situ Keratomileusis Surgical Flap

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):e183084. doi:10.1001/jamaophthalmol.2018.3084

This case describes a 23-year-old man who experienced an infestation of an insect larva in his eye after a laser-assisted in situ keratomileusis surgery.

Correction

Error in End Matter

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):1078. doi:10.1001/jamaophthalmol.2018.2976
JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
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JAMA Ophthalmol. 2018;136(9):966. doi:10.1001/jamaophthalmol.2017.3744
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