January 2019, Vol 137, No. 1, Pages 1-121

A boy in his late teens with short stature presented with gradual loss of vision in both eyes since 8 years of age, a diagnosis of type 1 diabetes at 10 years of age, hearing loss during the past 2 years, hypochondroplasia, alopecia, and generalized hypotonia. What would you do next?

A man in his 50s presented with a 2-year history of optic disc edema in the right eye, double vision, and graying of vision; examination found prominent chronic-appearing optic disc edema in the right eye and superior greater than inferior peripheral field loss in the right eye. What would you do next?

A middle-aged man presents with painless blurry vision in the left eye and bilateral subretinal fluid in the macula. Late-phase fluorescein angiography reveals multifocal pinpoint areas of hyperfluorescence with mild leakage. What would you do next?

A 60-year-old man presents with a 6-month history of progressive painless visual loss, photophobia, and color vision impairment in both eyes. What would you do next?

A woman in her 70s reports difficulty seeing in dimly lit settings for the past 6 years and is referred for evaluation. Her best-corrected visual acuity is 20/40 OD and 20/25 OS, and spectral-domain optical coherence tomography shows complete loss of photoreceptors outside the fovea. What would you do next?

This case report describes a woman in her mid-70s who was referred for bilateral choroidal lesions and, on presentation, described her vision as blurred in the left eye. Confrontation visual fields revealed a deficit in the inferotemporal quadrant of the left eye, and fluorescein and indocyanine angiography demonstrated leakage in the area of subretinal hemorrhage in the left eye. What would you do next?