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December 2019 - January 1929

Decade

Year

Issue

December 2019, Vol 137, No. 12, Pages 1343-1468

In This Issue of JAMA Ophthalmology

Highlights

Abstract Full Text
free access
JAMA Ophthalmol. 2019;137(12):1343. doi:10.1001/jamaophthalmol.2018.4803
Viewpoint

US Food and Drug Administration Regulatory Programs for Innovative Technologies

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1349-1350. doi:10.1001/jamaophthalmol.2019.3708

This Viewpoint describes US Food and Drug Administration programs designed with the aim of enhancing and expediting the regulatory process to bring ophthalmic devices to patients more rapidly and efficiently.

Editorial

Waste in the US Health Care System—Insights for Vision Health

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1351-1352. doi:10.1001/jamaophthalmol.2019.4647
Original Investigation

Development and Validation of a Deep Learning System to Detect Glaucomatous Optic Neuropathy Using Fundus Photographs

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2019;137(12):1353-1360. doi:10.1001/jamaophthalmol.2019.3501

This cross-sectional study compares the sensitivity and specificity of automated classification of glaucomatous optic neuropathy on retinal fundus images by a deep-learning system with classification by human experts, using Chinese, multiethnic, and website-based data sets.

Patterns of Pediatric Firearm-Related Ocular Trauma in the United States

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1363-1370. doi:10.1001/jamaophthalmol.2019.3562

This study evaluates the epidemiologic patterns of firearm-related ocular injuries among children and adolescents in the United States, using multiyear demographic, hospitalization, and clinical data reported in the National Trauma Data Bank.

Effects of Flavanol-Rich Dark Chocolate on Visual Function and Retinal Perfusion Measured With Optical Coherence Tomography Angiography: A Randomized Clinical Trial

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1373-1379. doi:10.1001/jamaophthalmol.2019.3731

This randomized clinical trial assesses the effects of dark chocolate flavanols on subjective visual function and retinal perfusion objectively quantified on optical coherence tomography angiography.

Utility of In Vitro Mutagenesis of RPE65 Protein for Verification of Mutational Pathogenicity Before Gene Therapy

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1381-1388. doi:10.1001/jamaophthalmol.2019.3914

This case series describes an in vitro mutagenesis assay performed to confirm pathogenicity in 4 children or adolescents with Leber congenital amaurosis.

Month 24 Outcomes After Treatment Initiation With Anti–Vascular Endothelial Growth Factor Therapy for Macular Edema Due to Central Retinal or Hemiretinal Vein Occlusion: SCORE2 Report 10: A Secondary Analysis of the SCORE2 Randomized Clinical Trial

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1389-1398. doi:10.1001/jamaophthalmol.2019.3947

This secondary analysis of a randomized clinical trial investigates outcomes 1 year after cessation of the SCORE2 treatment schedule (24 months after randomization) in patients treated with anti–vascular endothelial growth factor (anti-VEGF) therapy for macular edema due to central retinal or hemiretinal vein occlusion.

Evaluation of Systematic Reviews of Interventions for Retina and Vitreous Conditions

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1399-1405. doi:10.1001/jamaophthalmol.2019.4016

This cross-sectional study of systematic reviews assesses the reliability of systematic reviews on interventions for 7 retina and vitreous conditions.

Association of Secondhand Smoking Exposure With Choroidal Thinning in Children Aged 6 to 8 Years: The Hong Kong Children Eye Study

Abstract Full Text
has active quiz has audio
JAMA Ophthalmol. 2019;137(12):1406-1414. doi:10.1001/jamaophthalmol.2019.4178

This cross-sectional study assesses the association between choroidal thickness and secondhand smoking exposure in children.

Accuracy of Kalman Filtering in Forecasting Visual Field and Intraocular Pressure Trajectory in Patients With Ocular Hypertension

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1416-1423. doi:10.1001/jamaophthalmol.2019.4190

This cohort study uses data from patients with ocular hypertension to assess how well Kalman filtering, a machine learning approach used in aviation, can forecast disease trajectory up to 5 years into the future.

Five-Year Cost-effectiveness of Intravitreous Ranibizumab Therapy vs Panretinal Photocoagulation for Treating Proliferative Diabetic Retinopathy: A Secondary Analysis of a Randomized Clinical Trial

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1424-1432. doi:10.1001/jamaophthalmol.2019.4284

This preplanned secondary analysis of a randomized clinical trial assesses the 5- and 10-year incremental cost-effectiveness ratios of ranibizumab therapy compared with panretinal photocoagulation for treating patients diagnosed with proliferative diabetic retinopathy.

Brief Report

Intraocular Metastasis in Unilateral Multifocal Uveal Melanoma Without Melanocytosis or Germline BAP1 Mutations

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1434-1439. doi:10.1001/jamaophthalmol.2019.3941

This clinical case series evaluates the pathogenesis of unilateral multifocal uveal melanoma in 4 affected individuals.

Corneal Inlay Damage After Cosmetic Laser Treatment of the Eyelid With Long-Pulsed Nd:YAG Laser

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1440-1443. doi:10.1001/jamaophthalmol.2019.4126

This case report describes the occurrence of corneal inlay damage following treatment to the eyelids and face with an Nd:YAG laser.

Integrative Exome and Transcriptome Analysis of Conjunctival Melanoma and Its Potential Application for Personalized Therapy

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1444-1448. doi:10.1001/jamaophthalmol.2019.4237

This case series examines the use of integrative exome and transcriptome analysis of genes and mutations in 8 patients with conjunctival melanoma.

Invited Commentary

Finding Glaucoma in Color Fundus Photographs Using Deep Learning

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1361-1362. doi:10.1001/jamaophthalmol.2019.3512

A Vision for the Future of Pediatric Firearm-Related Ocular Trauma

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1371-1372. doi:10.1001/jamaophthalmol.2019.3587

Does Dark Chocolate Enhance Visual Function?

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1380. doi:10.1001/jamaophthalmol.2019.3740

Early Exposure to Secondhand Smoking and Ocular Health—Insights From Latest-Generation Optical Coherence Tomographic Imaging

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1414-1415. doi:10.1001/jamaophthalmol.2019.4185

Recognizing the True Cost of Medical Spending—An Assessment of Ranibizumab for Retinal Disorders

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1432-1433. doi:10.1001/jamaophthalmol.2019.4275
From the JAMA Network

Antimetabolite Therapy for Uveitis: Methotrexate or Mycophenolate?

Abstract Full Text
free access
JAMA Ophthalmol. 2019;137(12):1449-1451. doi:10.1001/jamaophthalmol.2019.3964

This article discusses a study published in JAMA of the effect of methrotrexate vs mycophenolate as the single immunosuppressive agent on the treatment of noninfectious intermediate, posterior, and panuveitides.

JAMA Ophthalmology Clinical Challenge

An Amelanotic Choroidal Mass in a Middle-aged Woman

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2019;137(12):1452-1453. doi:10.1001/jamaophthalmol.2019.4134

A middle-aged woman presents with unilateral blurry vision, and imaging reveals a choroidal mass. What would you do next?

Unusual Vitreous Opacity in a Chinese Patient

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2019;137(12):1454-1455. doi:10.1001/jamaophthalmol.2019.4098

A Chinese woman had a painless, gradually declined vision for 2 years without redness. What would you do next?

An Orbital Lesion Diagnosed on Routine Fundus Examination

Abstract Full Text
has active quiz
JAMA Ophthalmol. 2019;137(12):1456-1457. doi:10.1001/jamaophthalmol.2019.4106

A man in his 80s with pseudophakia presented for routine follow-up of an elevated choroidal nevus in his right eye. His slitlamp and fundus examinations were unremarkable aside from the choroidal nevus, and a new retro-orbital hypoechoic cavity causing right globe deformation was noted on B-scan ultrasonography. What would you do next?

Research Letter

Complement Proteins in the Retina in Cancer-Associated Retinopathy

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1458-1460. doi:10.1001/jamaophthalmol.2019.4405

This case series evaluates the classical complement pathway in eyes with cancer-associated retinopathy.

Observation

Ophthalmic and Central Retinal Artery Occlusion Following Triamcinolone Injection of the Lacrimal Gland

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1460-1461. doi:10.1001/jamaophthalmol.2019.3998

This case report describes a woman with central retinal artery occlusion following triamcinolone injection of the lacrimal gland.

Epithelial Invasion Following Descemet Membrane Endothelial Keratoplasty and Associated With Subsequent Central Graft Detachment

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1461-1463. doi:10.1001/jamaophthalmol.2019.4566

This case report details a case of epithelial invasion after Descemet membrane endothelial keratoplasty in an elderly woman.

Ophthalmic Images

Rubeosis Iridis With Budding New Vessels

Abstract Full Text
online only
JAMA Ophthalmol. 2019;137(12):e190027. doi:10.1001/jamaophthalmol.2019.0027

This case report describes rubeosis iridis in a woman who was found to also have proliferative diabetic retinopathy in both eyes.

Toxic Crystalline Retinopathy Associated With an Overdose of Intravitreal Ganciclovir

Abstract Full Text
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JAMA Ophthalmol. 2019;137(12):e190039. doi:10.1001/jamaophthalmol.2019.0039

This case report describes the aftermath of an unintentional overdose of intraviteal ganciclovir in the left eye of a man with macular atrophy secondary to Good syndrome–associated cytomegalovirus retinitis.

Conjunctival and Episcleral Blood Flow Restoration After Strabismus Surgery on Swept-Source Optical Coherence Tomography Angiography

Abstract Full Text
online only
JAMA Ophthalmol. 2019;137(12):e190043. doi:10.1001/jamaophthalmol.2019.0043

This case report describes how conjunctival and episcleral blood flow can be visualized using optical coherence tomography angiography.

A Nonhaptic, Large-Diameter, Unfoldable Intraocular Lens Dislocated Into the Vitreous Cavity

Abstract Full Text
online only
JAMA Ophthalmol. 2019;137(12):e190047. doi:10.1001/jamaophthalmol.2019.0047

This case report describes an unusual sequal to the implantation of an intraocular lens and describes the method used to correct it.

Comment & Response

Confirmation That Angioid Streaks Are Not Common in Ehlers-Danlos Syndrome

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1463. doi:10.1001/jamaophthalmol.2019.2549

Limits of Milk and Dark Chocolate Bars’ Effects on Human Visual Acuity and Contrast Sensitivity

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1463-1464. doi:10.1001/jamaophthalmol.2019.3789

Limits of Milk and Dark Chocolate Bars’ Effects on Human Visual Acuity and Contrast Sensitivity—Reply

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1464. doi:10.1001/jamaophthalmol.2019.3795

Missed Heterozygous Deletion in Study of Next-Generation Sequencing for Molecular Diagnosis in Patients With Infantile Nystagmus Syndrome

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1465-1466. doi:10.1001/jamaophthalmol.2019.3755

Diffuse Uveal Melanocytic Proliferation With Primary Vitreoretinal Lymphoma

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1466. doi:10.1001/jamaophthalmol.2019.4260

Diffuse Uveal Melanocytic Proliferation With Primary Vitreoretinal Lymphoma—Reply

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1466-1467. doi:10.1001/jamaophthalmol.2019.4263

Using Machine Learning to Monitor Keratoconus Progression

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1467-1468. doi:10.1001/jamaophthalmol.2019.4198

Using Machine Learning to Monitor Keratoconus Progression—Reply

Abstract Full Text
JAMA Ophthalmol. 2019;137(12):1468. doi:10.1001/jamaophthalmol.2019.4201
Correction

Error in Byline

Abstract Full Text
free access
JAMA Ophthalmol. 2019;137(12):1468. doi:10.1001/jamaophthalmol.2019.5103

Errors in Table 2

Abstract Full Text
free access
JAMA Ophthalmol. 2019;137(12):1468. doi:10.1001/jamaophthalmol.2019.3190
JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
free access
JAMA Ophthalmol. 2019;137(12):1345. doi:10.1001/jamaophthalmol.2018.4804
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